{"id":"86d3354b-a8d7-52aa-bc28-01960c24c141","stable_key":"e0ea2d6a-7429-5e9f-b774-41e5e3288da3:ve-transport-npc1l1-uptake","predicate":"supports_uptake","statement":"Human NPC1L1 overexpression increased alpha-tocopherol uptake, which was inhibited by ezetimibe.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"positive","is_public":true,"mechanism_event_id":"b9e37346-18f0-5560-b17a-9b04ede84fbe","mechanism_event_label":"The cholesterol transporter NPC1L1 can also take up vitamin E.","subject":{"id":"9fbf0133-53c3-5ab1-8a95-4804d6115300","slug":"npc1l1","display_name":"Human Niemann-Pick C1-like protein 1 / NPC1L1","entity_type_key":"protein"},"object":{"id":"3436f320-f9dd-5606-9a37-507e5944ee6c","slug":"intestinal-alpha-tocopherol-uptake","display_name":"Intestinal alpha-tocopherol uptake","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"b9e37346-18f0-5560-b17a-9b04ede84fbe","stable_key":"e0ea2d6a-7429-5e9f-b774-41e5e3288da3:ve-transport-npc1l1-uptake-event","event_type":"biochemical_relationship","label":"The cholesterol transporter NPC1L1 can also take up vitamin E.","description":"Human NPC1L1 overexpression increased alpha-tocopherol uptake, which was inhibited by ezetimibe.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"9fbf0133-53c3-5ab1-8a95-4804d6115300","slug":"npc1l1","display_name":"Human Niemann-Pick C1-like protein 1 / NPC1L1","entity_type_key":"protein"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"3436f320-f9dd-5606-9a37-507e5944ee6c","slug":"intestinal-alpha-tocopherol-uptake","display_name":"Intestinal alpha-tocopherol uptake","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"40a6525a-76b8-576e-b73d-1e11aecf5f8d","slug":"alpha-tocopherol","display_name":"Alpha-tocopherol","entity_type_key":"small_molecule"},"role":"uptake_substrate","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""}]},"contexts":[{"dimension":"cross_nutrient","value_text":"false","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Human NPC1L1 overexpression uptake assay","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure","value_text":"NPC1L1 expression with alpha-tocopherol and ezetimibe; dose/time not reported in abstract.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Cell experiment does not establish a clinical vitamin E deficiency from ezetimibe.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Vitamin E research collection; topical membership is not evidence of a direct dietary effect.","comparator":null,"unit":null,"notes":"","entity":{"slug":"vitamin-e","display_name":"Vitamin E","entity_type_key":"chemical_species"}},{"dimension":"organism","value_text":"Human protein in cultured cells","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"The cholesterol transporter NPC1L1 can also take up vitamin E.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[narushima2008] Niemann-pick C1-like 1 mediates alpha-tocopherol transport. (2008). https://pubmed.ncbi.nlm.nih.gov/18403720/ DOI: 10.1124/mol.107.043034","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"Cellular uptake model","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"d2cc0ed1-56a2-5184-a4b9-88d6ab52f691","evidence_kind":"source_excerpt","locator":"Lines 207-218","start_line":207,"end_line":218,"excerpt":"### ve-transport-npc1l1-uptake\nHuman NPC1L1 overexpression increased alpha-tocopherol uptake, which was inhibited by ezetimibe.\nCondition category: normal\nnutrient_topic: Vitamin E research collection; topical membership is not evidence of a direct dietary effect.\nplain_language: The cholesterol transporter NPC1L1 can also take up vitamin E.\norganism: Human protein in cultured cells\ntissue_or_cell_type: Cellular uptake model\nexperimental_model: Human NPC1L1 overexpression uptake assay\nlimitations: Cell experiment does not establish a clinical vitamin E deficiency from ezetimibe.\nexposure: NPC1L1 expression with alpha-tocopherol and ezetimibe; dose/time not reported in abstract.\ncross_nutrient: false\n[narushima2008] Niemann-pick C1-like 1 mediates alpha-tocopherol transport. (2008). https://pubmed.ncbi.nlm.nih.gov/18403720/ DOI: 10.1124/mol.107.043034","model_system":"Human NPC1L1 overexpression uptake assay","directness":"author_interpretation","verification_status":"source_derived_draft","notes":"Exact curation-document quotation, not publisher quotation. Study references: [narushima2008] Niemann-pick C1-like 1 mediates alpha-tocopherol transport. (2008). https://pubmed.ncbi.nlm.nih.gov/18403720/ DOI: 10.1124/mol.107.043034","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"3ac41dba-4727-5116-a556-ac3bbb0dc41c","stable_key":"import-e0ea2d6a-7429-5e9f-b774-41e5e3288da3","title":"Vitamin E: transport, membrane protection and nutrient interactions (2026-09-17)","document_type":"imported_text","citation_label":"AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text.","file_path":"","sha256":"a90b6565e092c6a2da07f74cf758792c2cf63b40746260c8ff12bd64322c36f4","revision_id":"956793d1-23e4-5397-9291-25c1732a8e02","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}