Component

Inosine 5-prime-monophosphate / IMP

Context-specific entity; species, compartment and exposure are stated on each claim.

3 recorded relationships. Experimental role, claim status and evidence remain attached to each record.

Read recorded mechanisms Open recursive mind map

How nutrients influence it

Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.

How nutrients reach it in more than one step

Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.

Tracing routes…

What it does

Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.

Recorded relationships

What it acts on

  1. Glutamate plus IMP enhanced bicarbonate secretion in rat duodenum.

    Inosine 5-prime-monophosphate / IMP → Rat duodenal bicarbonate secretion source_derived_draftungraded
    Experimental context and source evidence
    evidence_access
    Primary abstract
    experimental_model
    Rat perfusion; IMP 0.1 mM.
    limitations
    T1R involvement was inferred; not proved by receptor deletion.
    nutrient_topic
    Monosodium Glutamate (MSG) collection; species, compartment, exposure, co-substrates and manipulation remain explicit. · Monosodium L-glutamate
    plain_language
    The two-compound interaction also reached a gut endpoint.
    primary_references
    Luminal L-glutamate enhances duodenal mucosal defense mechanisms via multiple glutamate receptors in rats. · 2009 · https://pubmed.ncbi.nlm.nih.gov/19643955/ · DOI 10.1152/ajpgi.90605.2008

    Monosodium Glutamate (MSG): taste, gut sensing, exposure and cross-nutrient mechanisms (2026-09-20) · lines 202–208

    AI-assisted research curation; primary references, access levels and experimental limitations individually identified. Not publisher full text. · supports · Rat perfusion; IMP 0.1 mM. · source_derived_draft · unverified_draft

    ## monosodium-glutamate-duodenal-imp The two-compound interaction also reached a gut endpoint. Glutamate plus IMP enhanced bicarbonate secretion in rat duodenum. Model: Rat perfusion; IMP 0.1 mM. Limitations: T1R involvement was inferred; not proved by receptor deletion. Evidence access: Primary abstract Luminal L-glutamate enhances duodenal mucosal defense mechanisms via multiple glutamate receptors in rats. · 2009 · https://pubmed.ncbi.nlm.nih.gov/19643955/ · DOI 10.1152/ajpgi.90605.2008
    Complete structured claim and evidence

  2. The cooperative model places a 5-prime-ribonucleotide at an adjacent opening-side site, stabilizing the closed glutamate-bound receptor conformation.

    Inosine 5-prime-monophosphate / IMP → Human taste receptor TAS1R1 source_derived_draftungraded
    Experimental context and source evidence
    evidence_access
    Primary abstract
    experimental_model
    Same mutagenesis/chimera/model study.
    limitations
    Do not extrapolate taste synergy to a general systemic metabolic benefit.
    nutrient_topic
    Monosodium Glutamate (MSG) collection; species, compartment, exposure, co-substrates and manipulation remain explicit. · Monosodium L-glutamate
    plain_language
    IMP can amplify a glutamate signal through a different receptor contact.
    primary_references
    Molecular mechanism for the umami taste synergism. · 2008 · https://pubmed.ncbi.nlm.nih.gov/19104071/ · DOI 10.1073/pnas.0810174106

    Monosodium Glutamate (MSG): taste, gut sensing, exposure and cross-nutrient mechanisms (2026-09-20) · lines 82–88

    AI-assisted research curation; primary references, access levels and experimental limitations individually identified. Not publisher full text. · supports · Same mutagenesis/chimera/model study. · source_derived_draft · unverified_draft

    ## monosodium-glutamate-imp-cooperation IMP can amplify a glutamate signal through a different receptor contact. The cooperative model places a 5-prime-ribonucleotide at an adjacent opening-side site, stabilizing the closed glutamate-bound receptor conformation. Model: Same mutagenesis/chimera/model study. Limitations: Do not extrapolate taste synergy to a general systemic metabolic benefit. Evidence access: Primary abstract Molecular mechanism for the umami taste synergism. · 2008 · https://pubmed.ncbi.nlm.nih.gov/19104071/ · DOI 10.1073/pnas.0810174106
    Complete structured claim and evidence

  3. 5-prime-ribonucleotides enhanced the human T1R1/T1R3 response to L-glutamate.

    Inosine 5-prime-monophosphate / IMP → Human umami receptor TAS1R1/TAS1R3 source_derived_draftungraded
    Experimental context and source evidence
    evidence_access
    Primary abstract
    experimental_model
    Human receptor coexpression and ligand-response assays.
    limitations
    A measured receptor interaction, not a general metabolic or clinical synergy.
    nutrient_topic
    L-Glutamate collection; species, compartment, exposure, co-substrates and manipulation remain explicit. · L-Glutamate
    plain_language
    A nucleotide can enhance the response to an amino acid at a receptor.
    primary_references
    Human receptors for sweet and umami taste. · 2002 · https://pubmed.ncbi.nlm.nih.gov/11917125/ · DOI 10.1073/pnas.072090199

    L-Glutamate / L-glutamic acid: carbon and nitrogen allocation, signaling and cross-nutrient mechanisms (2026-09-19) · lines 50–56

    AI-assisted research curation; primary references, access levels and experimental limitations individually identified. Not publisher full text. · supports · Human receptor coexpression and ligand-response assays. · source_derived_draft · unverified_draft

    ## glutamate-umami-nucleotide A nucleotide can enhance the response to an amino acid at a receptor. 5-prime-ribonucleotides enhanced the human T1R1/T1R3 response to L-glutamate. Model: Human receptor coexpression and ligand-response assays. Limitations: A measured receptor interaction, not a general metabolic or clinical synergy. Evidence access: Primary abstract Human receptors for sweet and umami taste. · 2002 · https://pubmed.ncbi.nlm.nih.gov/11917125/ · DOI 10.1073/pnas.072090199
    Complete structured claim and evidence

In the sources

Preserved passages that mention this component, quoted exactly. Open one to read it in context.

    This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.

    Evidence, AI assistance and curation standards