{"id":"026d3b7e-7a81-5ebb-ac10-ff439ce7fae0","stable_key":"b7014def-74ec-599e-8347-167e24fec1f0:glutamate-umami-nucleotide","predicate":"enhances_glutamate_response","statement":"5-prime-ribonucleotides enhanced the human T1R1/T1R3 response to L-glutamate.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"684076e8-b574-5be8-8085-38574466abfc","mechanism_event_label":"A nucleotide can enhance the response to an amino acid at a receptor.","subject":{"id":"11dac15d-169a-517e-9121-418d72d5fb2c","slug":"inosine-monophosphate","display_name":"Inosine 5-prime-monophosphate / IMP","entity_type_key":"small_molecule"},"object":{"id":"1d944380-d3e6-5e01-9649-43407fbcf8ed","slug":"human-tas1r1-tas1r3","display_name":"Human umami receptor TAS1R1/TAS1R3","entity_type_key":"protein_complex"},"evidence_count":1,"mechanism_event":{"id":"684076e8-b574-5be8-8085-38574466abfc","stable_key":"b7014def-74ec-599e-8347-167e24fec1f0:glutamate-umami-nucleotide-event","event_type":"observed_relationship","label":"A nucleotide can enhance the response to an amino acid at a receptor.","description":"5-prime-ribonucleotides enhanced the human T1R1/T1R3 response to L-glutamate.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"11dac15d-169a-517e-9121-418d72d5fb2c","slug":"inosine-monophosphate","display_name":"Inosine 5-prime-monophosphate / IMP","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"1d944380-d3e6-5e01-9649-43407fbcf8ed","slug":"human-tas1r1-tas1r3","display_name":"Human umami receptor TAS1R1/TAS1R3","entity_type_key":"protein_complex"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"7da684a4-2641-5bc6-93ae-8c6aa384e487","slug":"glutamate","display_name":"L-Glutamate","entity_type_key":"small_molecule"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""},{"entity":{"id":"2c1c5c5f-2f58-545e-9a08-b2a63ba1c8f5","slug":"tas1r1","display_name":"Human taste receptor TAS1R1","entity_type_key":"protein"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":3,"notes":""},{"entity":{"id":"7ab6f209-2089-5008-b64e-64f8db8c7771","slug":"tas1r3","display_name":"Human taste receptor TAS1R3","entity_type_key":"protein"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":4,"notes":""}]},"contexts":[{"dimension":"evidence_access","value_text":"Primary abstract","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Human receptor coexpression and ligand-response assays.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"A measured receptor interaction, not a general metabolic or clinical synergy.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"L-Glutamate collection; species, compartment, exposure, co-substrates and manipulation remain explicit.","comparator":null,"unit":null,"notes":"","entity":{"slug":"glutamate","display_name":"L-Glutamate","entity_type_key":"small_molecule"}},{"dimension":"plain_language","value_text":"A nucleotide can enhance the response to an amino acid at a receptor.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"Human receptors for sweet and umami taste. · 2002 · https://pubmed.ncbi.nlm.nih.gov/11917125/ · DOI 10.1073/pnas.072090199","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"c109034f-fd37-5b20-b571-9e522a878f47","evidence_kind":"source_excerpt","locator":"Lines 50-56","start_line":50,"end_line":56,"excerpt":"## glutamate-umami-nucleotide\nA nucleotide can enhance the response to an amino acid at a receptor.\n5-prime-ribonucleotides enhanced the human T1R1/T1R3 response to L-glutamate.\nModel: Human receptor coexpression and ligand-response assays.\nLimitations: A measured receptor interaction, not a general metabolic or clinical synergy.\nEvidence access: Primary abstract\nHuman receptors for sweet and umami taste. · 2002 · https://pubmed.ncbi.nlm.nih.gov/11917125/ · DOI 10.1073/pnas.072090199","model_system":"Human receptor coexpression and ligand-response assays.","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Original curation paraphrase; 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