{"id":"c12445d0-e227-5d70-85d4-1de8ee480c02","stable_key":"561b2b40-5b59-548f-a749-f357f7e2304c:monosodium-glutamate-duodenal-imp","predicate":"enhances_glutamate_response_in","statement":"Glutamate plus IMP enhanced bicarbonate secretion in rat duodenum.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"22154de8-2570-5e8a-b367-a4d4e1b88758","mechanism_event_label":"The two-compound interaction also reached a gut endpoint.","subject":{"id":"11dac15d-169a-517e-9121-418d72d5fb2c","slug":"inosine-monophosphate","display_name":"Inosine 5-prime-monophosphate / IMP","entity_type_key":"small_molecule"},"object":{"id":"0d1fb95a-c6ca-531e-a895-1a3dc793b0f7","slug":"rat-duodenal-bicarbonate-secretion","display_name":"Rat duodenal bicarbonate secretion","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"22154de8-2570-5e8a-b367-a4d4e1b88758","stable_key":"561b2b40-5b59-548f-a749-f357f7e2304c:monosodium-glutamate-duodenal-imp-event","event_type":"observed_relationship","label":"The two-compound interaction also reached a gut endpoint.","description":"Glutamate plus IMP enhanced bicarbonate secretion in rat duodenum.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"11dac15d-169a-517e-9121-418d72d5fb2c","slug":"inosine-monophosphate","display_name":"Inosine 5-prime-monophosphate / IMP","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"0d1fb95a-c6ca-531e-a895-1a3dc793b0f7","slug":"rat-duodenal-bicarbonate-secretion","display_name":"Rat duodenal bicarbonate secretion","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"2952387b-d69b-5530-a976-a875ad008226","slug":"monosodium-glutamate","display_name":"Monosodium L-glutamate","entity_type_key":"small_molecule"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""},{"entity":{"id":"7da684a4-2641-5bc6-93ae-8c6aa384e487","slug":"glutamate","display_name":"L-Glutamate","entity_type_key":"small_molecule"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":3,"notes":""},{"entity":{"id":"edf44f6b-7b23-5b97-a86b-c940e5812b06","slug":"bicarbonate-ion","display_name":"Bicarbonate ion","entity_type_key":"ion"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":4,"notes":""}]},"contexts":[{"dimension":"evidence_access","value_text":"Primary abstract","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Rat perfusion; 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IMP 0.1 mM.\nLimitations: T1R involvement was inferred; not proved by receptor deletion.\nEvidence access: Primary abstract\nLuminal L-glutamate enhances duodenal mucosal defense mechanisms via multiple glutamate receptors in rats. · 2009 · https://pubmed.ncbi.nlm.nih.gov/19643955/ · DOI 10.1152/ajpgi.90605.2008","model_system":"Rat perfusion; IMP 0.1 mM.","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Original curation paraphrase; evidence access and experimental limitations specified.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"90a81fe5-8622-52f6-b4db-04899206c2b0","stable_key":"import-561b2b40-5b59-548f-a749-f357f7e2304c","title":"Monosodium Glutamate (MSG): taste, gut sensing, exposure and cross-nutrient mechanisms (2026-09-20)","document_type":"imported_text","citation_label":"AI-assisted research curation; primary references, access levels and experimental limitations individually identified. 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