{"id":"360c41cf-b305-5e58-afda-458ac8f6ff7b","stable_key":"561b2b40-5b59-548f-a749-f357f7e2304c:monosodium-glutamate-imp-cooperation","predicate":"stabilizes_proposed_active_state_of","statement":"The cooperative model places a 5-prime-ribonucleotide at an adjacent opening-side site, stabilizing the closed glutamate-bound receptor conformation.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"7398f274-9aac-5023-b67c-e12292edb0e1","mechanism_event_label":"IMP can amplify a glutamate signal through a different receptor contact.","subject":{"id":"11dac15d-169a-517e-9121-418d72d5fb2c","slug":"inosine-monophosphate","display_name":"Inosine 5-prime-monophosphate / IMP","entity_type_key":"small_molecule"},"object":{"id":"2c1c5c5f-2f58-545e-9a08-b2a63ba1c8f5","slug":"tas1r1","display_name":"Human taste receptor TAS1R1","entity_type_key":"protein"},"evidence_count":1,"mechanism_event":{"id":"7398f274-9aac-5023-b67c-e12292edb0e1","stable_key":"561b2b40-5b59-548f-a749-f357f7e2304c:monosodium-glutamate-imp-cooperation-event","event_type":"observed_relationship","label":"IMP can amplify a glutamate signal through a different receptor contact.","description":"The cooperative model places a 5-prime-ribonucleotide at an adjacent opening-side site, stabilizing the closed glutamate-bound receptor conformation.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"11dac15d-169a-517e-9121-418d72d5fb2c","slug":"inosine-monophosphate","display_name":"Inosine 5-prime-monophosphate / IMP","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"2c1c5c5f-2f58-545e-9a08-b2a63ba1c8f5","slug":"tas1r1","display_name":"Human taste receptor TAS1R1","entity_type_key":"protein"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"2952387b-d69b-5530-a976-a875ad008226","slug":"monosodium-glutamate","display_name":"Monosodium L-glutamate","entity_type_key":"small_molecule"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""},{"entity":{"id":"7da684a4-2641-5bc6-93ae-8c6aa384e487","slug":"glutamate","display_name":"L-Glutamate","entity_type_key":"small_molecule"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":3,"notes":""},{"entity":{"id":"7ab6f209-2089-5008-b64e-64f8db8c7771","slug":"tas1r3","display_name":"Human taste receptor TAS1R3","entity_type_key":"protein"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":4,"notes":""},{"entity":{"id":"1d944380-d3e6-5e01-9649-43407fbcf8ed","slug":"human-tas1r1-tas1r3","display_name":"Human umami receptor TAS1R1/TAS1R3","entity_type_key":"protein_complex"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":5,"notes":""}]},"contexts":[{"dimension":"evidence_access","value_text":"Primary abstract","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Same mutagenesis/chimera/model study.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Do not extrapolate taste synergy to a general systemic metabolic benefit.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Monosodium Glutamate (MSG) collection; species, compartment, exposure, co-substrates and manipulation remain explicit.","comparator":null,"unit":null,"notes":"","entity":{"slug":"monosodium-glutamate","display_name":"Monosodium L-glutamate","entity_type_key":"small_molecule"}},{"dimension":"plain_language","value_text":"IMP can amplify a glutamate signal through a different receptor contact.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"Molecular mechanism for the umami taste synergism. · 2008 · https://pubmed.ncbi.nlm.nih.gov/19104071/ · DOI 10.1073/pnas.0810174106","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"9ad7d142-7f5f-5f5d-aab9-56a224163080","evidence_kind":"source_excerpt","locator":"Lines 82-88","start_line":82,"end_line":88,"excerpt":"## monosodium-glutamate-imp-cooperation\nIMP can amplify a glutamate signal through a different receptor contact.\nThe cooperative model places a 5-prime-ribonucleotide at an adjacent opening-side site, stabilizing the closed glutamate-bound receptor conformation.\nModel: Same mutagenesis/chimera/model study.\nLimitations: Do not extrapolate taste synergy to a general systemic metabolic benefit.\nEvidence access: Primary abstract\nMolecular mechanism for the umami taste synergism. · 2008 · https://pubmed.ncbi.nlm.nih.gov/19104071/ · DOI 10.1073/pnas.0810174106","model_system":"Same mutagenesis/chimera/model study.","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Original curation paraphrase; 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Not publisher full text.","file_path":"","sha256":"53052c19ee82d400eff7d82ffa3cff74747c7f91a8d173efa3f46eba6bd87cce","revision_id":"fdb64139-32f4-537e-bb0f-f242f2779da8","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}