Component
Human THP-1 LPS-induced cytokine release
Context-specific entity; species, compartment and exposure are stated on each claim.
2 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
What acts on it
Stevioside at 1 mM suppressed LPS-induced TNF and IL-1beta release in human THP-1 cells, with suppression of IKKbeta and NF-kappaB activation.
Experimental context and source evidence
- evidence_access
- Primary abstract
- experimental_model
- Human monocyte-derived cell line with LPS stimulation.
- limitations
- High direct exposure is not demonstrated after dietary sweetener use; pathway inhibition does not establish direct protein binding.
- nutrient_topic
- Stevia collection; species, compartment, exposure, co-substrates and manipulation remain explicit. · Stevia
- plain_language
- The inflammatory state changes what the compound does.
- primary_references
- Anti-Inflammatory and Immunomodulatory Activities of Stevioside and Its Metabolite Steviol on THP-1 Cells. · 2006 · https://pubmed.ncbi.nlm.nih.gov/16448183/ · DOI 10.1021/jf0523465
Stevia: glycoside metabolism, taste, ion channels and cross-nutrient mechanisms (2026-09-19) · lines 322–328
AI-assisted research curation; primary references, access levels and experimental limitations individually identified. Not publisher full text. · supports · Human monocyte-derived cell line with LPS stimulation. · source_derived_draft · unverified_draft
## stevia-immune-stimulated The inflammatory state changes what the compound does. Stevioside at 1 mM suppressed LPS-induced TNF and IL-1beta release in human THP-1 cells, with suppression of IKKbeta and NF-kappaB activation. Model: Human monocyte-derived cell line with LPS stimulation. Limitations: High direct exposure is not demonstrated after dietary sweetener use; pathway inhibition does not establish direct protein binding. Evidence access: Primary abstract Anti-Inflammatory and Immunomodulatory Activities of Stevioside and Its Metabolite Steviol on THP-1 Cells. · 2006 · https://pubmed.ncbi.nlm.nih.gov/16448183/ · DOI 10.1021/jf0523465
Complete structured claim and evidenceSteviol at 100 micromolar did not reproduce the LPS-response suppression observed with 1 mM stevioside.
Experimental context and source evidence
- evidence_access
- Primary abstract
- experimental_model
- Human THP-1 assay comparing distinct compounds at different concentrations.
- limitations
- Different doses prevent a simple potency ranking; no universal inactivity claim is made.
- nutrient_topic
- Stevia collection; species, compartment, exposure, co-substrates and manipulation remain explicit. · Stevia
- plain_language
- Metabolism changes which immune effects are observed.
- primary_references
- Anti-Inflammatory and Immunomodulatory Activities of Stevioside and Its Metabolite Steviol on THP-1 Cells. · 2006 · https://pubmed.ncbi.nlm.nih.gov/16448183/ · DOI 10.1021/jf0523465
Stevia: glycoside metabolism, taste, ion channels and cross-nutrient mechanisms (2026-09-19) · lines 338–344
AI-assisted research curation; primary references, access levels and experimental limitations individually identified. Not publisher full text. · supports · Human THP-1 assay comparing distinct compounds at different concentrations. · source_derived_draft · unverified_draft
## stevia-steviol-immune-null Metabolism changes which immune effects are observed. Steviol at 100 micromolar did not reproduce the LPS-response suppression observed with 1 mM stevioside. Model: Human THP-1 assay comparing distinct compounds at different concentrations. Limitations: Different doses prevent a simple potency ranking; no universal inactivity claim is made. Evidence access: Primary abstract Anti-Inflammatory and Immunomodulatory Activities of Stevioside and Its Metabolite Steviol on THP-1 Cells. · 2006 · https://pubmed.ncbi.nlm.nih.gov/16448183/ · DOI 10.1021/jf0523465
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.