Component

Human sucrose malabsorption assessed by breath hydrogen

Species, exposure, manipulation and limitations are specified on each linked claim.

3 recorded relationships. Experimental role, claim status and evidence remain attached to each record.

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How nutrients influence it

Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.

How nutrients reach it in more than one step

Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.

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What it does

Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.

Recorded relationships

What acts on it

  1. None of ten healthy volunteers showed breath-hydrogen malabsorption after the tested 50, 75 or 100 g sucrose loads.

    Sucrose → Human sucrose malabsorption assessed by breath hydrogen source_derived_draftungraded
    Experimental context and source evidence
    dose
    Sucrose 50, 75 or 100 g; comparison with fructose alone
    duration
    Breath sampling over 3-4 hours
    evidence_access
    Primary abstract/metadata; unrecovered methods explicitly retained.
    evidence_scope
    literature_reviewed; source-specific curation
    experimental_model
    Ten healthy adult volunteers
    exposure_scope
    Human sucrose absorption
    limitations
    No detected breath-hydrogen malabsorption in a small healthy cohort is not proof that every person tolerates every dose; CSID is a distinct condition.
    nutrient_topic
    Sucrose chapter; direct sucrose observations are distinguished from shared component metabolism. · Sucrose
    organism
    Ten healthy adult volunteers
    plain_language
    None of ten healthy volunteers showed breath-hydrogen malabsorption after the tested 50, 75 or 100 g sucrose loads.
    primary_references
    Absorption capacity of fructose in healthy adults. Comparison with sucrose and its constituent monosaccharides. (1986). https://pubmed.ncbi.nlm.nih.gov/3781328/ DOI: 10.1136/gut.27.10.1161
    route
    Oral sugar solutions
    tissue
    Hydrogen breath tests

    Sucrose: mechanism of action and metabolic impact (2026-09-20) · lines 391–401

    Original AI-assisted source-specific sucrose curation with shared canonical claims retained by identity. Primary-study citations, negative findings, exposure details and limitations preserved. Not publisher full text. · supports · Ten healthy adult volunteers · source_derived_draft · unverified_draft

    ## sucrose-absorption None of ten healthy volunteers showed breath-hydrogen malabsorption after the tested 50, 75 or 100 g sucrose loads. Model/species: Ten healthy adult volunteers Tissue: Hydrogen breath tests Exposure: Sucrose 50, 75 or 100 g; comparison with fructose alone Route: Oral sugar solutions Duration: Breath sampling over 3-4 hours Exposure scope: Human sucrose absorption Limits: No detected breath-hydrogen malabsorption in a small healthy cohort is not proof that every person tolerates every dose; CSID is a distinct condition. Reference: Absorption capacity of fructose in healthy adults. Comparison with sucrose and its constituent monosaccharides. (1986). https://pubmed.ncbi.nlm.nih.gov/3781328/ DOI: 10.1136/gut.27.10.1161 Access: Primary abstract/metadata; unrecovered methods explicitly retained.
    Complete structured claim and evidence

  2. Breath hydrogen after 200 mg acarbose with 50 g sucrose indicated nearly complete sucrose malabsorption in the tolerance study.

    Acarbose → Human sucrose malabsorption assessed by breath hydrogen source_derived_draftungraded
    Experimental context and source evidence
    availability_state
    machinery_impairment Imported condition classification; unverified.
    dose
    50 g carbohydrate load; 200 or 50 mg acarbose
    duration
    Acute tolerance tests; exact sampling duration unrecovered
    evidence_access
    Primary abstract/metadata; unrecovered methods explicitly retained.
    evidence_scope
    literature_reviewed; source-specific curation
    experimental_model
    Healthy human volunteers; sample size unavailable in accessed abstract
    exposure_scope
    Drug and nutrient interaction
    limitations
    Acarbose inhibits carbohydrate hydrolysis. The glucose-only comparison does not support direct blockade of glucose transport. Experimental doses are not a dosing recommendation.
    nutrient_topic
    Sucrose chapter; direct sucrose observations are distinguished from shared component metabolism. · Sucrose
    organism
    Healthy human volunteers; sample size unavailable in accessed abstract
    plain_language
    Breath hydrogen after 200 mg acarbose with 50 g sucrose indicated nearly complete sucrose malabsorption in the tolerance study.
    primary_references
    Scope and specificity of acarbose in slowing carbohydrate absorption in man. (1981). https://pubmed.ncbi.nlm.nih.gov/7028548/ DOI: 10.2337/diab.30.11.951
    route
    Oral carbohydrate and drug
    tissue
    Carbohydrate tolerance and breath hydrogen
    trigger_kind
    machinery_impairment Imported condition classification; unverified.

    Sucrose: mechanism of action and metabolic impact (2026-09-20) · lines 211–221

    Original AI-assisted source-specific sucrose curation with shared canonical claims retained by identity. Primary-study citations, negative findings, exposure details and limitations preserved. Not publisher full text. · supports · Healthy human volunteers; sample size unavailable in accessed abstract · source_derived_draft · unverified_draft

    ## sucrose-acarbose-hydrogen Breath hydrogen after 200 mg acarbose with 50 g sucrose indicated nearly complete sucrose malabsorption in the tolerance study. Model/species: Healthy human volunteers; sample size unavailable in accessed abstract Tissue: Carbohydrate tolerance and breath hydrogen Exposure: 50 g carbohydrate load; 200 or 50 mg acarbose Route: Oral carbohydrate and drug Duration: Acute tolerance tests; exact sampling duration unrecovered Exposure scope: Drug and nutrient interaction Limits: Acarbose inhibits carbohydrate hydrolysis. The glucose-only comparison does not support direct blockade of glucose transport. Experimental doses are not a dosing recommendation. Reference: Scope and specificity of acarbose in slowing carbohydrate absorption in man. (1981). https://pubmed.ncbi.nlm.nih.gov/7028548/ DOI: 10.2337/diab.30.11.951 Access: Primary abstract/metadata; unrecovered methods explicitly retained.
    Complete structured claim and evidence

  3. Sacrosidase, with or without milk, reduced breath hydrogen after sucrose compared with placebo in children with CSID.

    Sacrosidase → Human sucrose malabsorption assessed by breath hydrogen source_derived_draftungraded
    Experimental context and source evidence
    availability_state
    machinery_impairment Imported condition classification; unverified.
    dose
    Yeast sucrase preparation, 6000 IU/mg protein; full strength and 1:10, 1:100, 1:1000 dilutions; >15 kg received 2 mL; lower-weight dose volume missing from accessed abstract
    duration
    Single-dose breath tests; four 10-day dose periods
    evidence_access
    Primary abstract/metadata; unrecovered methods explicitly retained.
    evidence_scope
    literature_reviewed; source-specific curation
    experimental_model
    28 children aged 5 months to 11 years with congenital sucrase-isomaltase deficiency; randomized double-blind trial
    exposure_scope
    Drug rescue of human genetic digestive impairment
    limitations
    Enzyme replacement in diagnosed CSID, not sucrose supplementation for a nutrient deficiency. Exact sucrose challenge amount and lower-weight volume unrecovered. Vomiting did not differ; wheezing occurred in one child with asthma. Not prescribing guidance.
    nutrient_topic
    Sucrose chapter; direct sucrose observations are distinguished from shared component metabolism. · Sucrose
    organism
    28 children aged 5 months to 11 years with congenital sucrase-isomaltase deficiency; randomized double-blind trial
    plain_language
    Sacrosidase, with or without milk, reduced breath hydrogen after sucrose compared with placebo in children with CSID.
    primary_references
    Sacrosidase therapy for congenital sucrase-isomaltase deficiency. (1999). https://pubmed.ncbi.nlm.nih.gov/9932843/ DOI: 10.1097/00005176-199902000-00008
    route
    Oral enzyme with sucrose challenge or normal carbohydrate-containing diet
    tissue
    Intestinal sucrose handling and stool/symptom outcomes
    trigger_kind
    machinery_impairment Imported condition classification; unverified.

    Sucrose: mechanism of action and metabolic impact (2026-09-20) · lines 163–173

    Original AI-assisted source-specific sucrose curation with shared canonical claims retained by identity. Primary-study citations, negative findings, exposure details and limitations preserved. Not publisher full text. · supports · 28 children aged 5 months to 11 years with congenital sucrase-isomaltase deficiency; randomized double-blind trial · source_derived_draft · unverified_draft

    ## sucrose-sacrosidase-hydrogen Sacrosidase, with or without milk, reduced breath hydrogen after sucrose compared with placebo in children with CSID. Model/species: 28 children aged 5 months to 11 years with congenital sucrase-isomaltase deficiency; randomized double-blind trial Tissue: Intestinal sucrose handling and stool/symptom outcomes Exposure: Yeast sucrase preparation, 6000 IU/mg protein; full strength and 1:10, 1:100, 1:1000 dilutions; >15 kg received 2 mL; lower-weight dose volume missing from accessed abstract Route: Oral enzyme with sucrose challenge or normal carbohydrate-containing diet Duration: Single-dose breath tests; four 10-day dose periods Exposure scope: Drug rescue of human genetic digestive impairment Limits: Enzyme replacement in diagnosed CSID, not sucrose supplementation for a nutrient deficiency. Exact sucrose challenge amount and lower-weight volume unrecovered. Vomiting did not differ; wheezing occurred in one child with asthma. Not prescribing guidance. Reference: Sacrosidase therapy for congenital sucrase-isomaltase deficiency. (1999). https://pubmed.ncbi.nlm.nih.gov/9932843/ DOI: 10.1097/00005176-199902000-00008 Access: Primary abstract/metadata; unrecovered methods explicitly retained.
    Complete structured claim and evidence

In the sources

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