{"id":"5039cfce-a86a-599b-81c4-2a99a312850e","stable_key":"c932089b-ebc9-5f39-b2e5-84af74f9f6d0:sucrose-sacrosidase-hydrogen","predicate":"reduces","statement":"Sacrosidase, with or without milk, reduced breath hydrogen after sucrose compared with placebo in children with CSID.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"negative","is_public":true,"mechanism_event_id":"36ee32d6-b40f-51e8-95a3-6672d894a4b7","mechanism_event_label":"Sacrosidase, with or without milk, reduced breath hydrogen after sucrose compared with placebo in children with CSID.","subject":{"id":"c753a693-6ae3-5dfd-be78-43d405670502","slug":"sacrosidase","display_name":"Sacrosidase","entity_type_key":"drug"},"object":{"id":"414cde7c-8aaa-513e-a6cc-e9c30b1ba8e8","slug":"human-sucrose-breath-test-malabsorption","display_name":"Human sucrose malabsorption assessed by breath hydrogen","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"36ee32d6-b40f-51e8-95a3-6672d894a4b7","stable_key":"c932089b-ebc9-5f39-b2e5-84af74f9f6d0:sucrose-sacrosidase-hydrogen-event","event_type":"observed_relationship","label":"Sacrosidase, with or without milk, reduced breath hydrogen after sucrose compared with placebo in children with CSID.","description":"Sacrosidase, with or without milk, reduced breath hydrogen after sucrose compared with placebo in children with CSID.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"c753a693-6ae3-5dfd-be78-43d405670502","slug":"sacrosidase","display_name":"Sacrosidase","entity_type_key":"drug"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"414cde7c-8aaa-513e-a6cc-e9c30b1ba8e8","slug":"human-sucrose-breath-test-malabsorption","display_name":"Human sucrose malabsorption assessed by breath hydrogen","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"82558bd0-1a84-574a-a04c-10609c9c5dba","slug":"sucrose","display_name":"Sucrose","entity_type_key":"small_molecule"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""},{"entity":{"id":"9ae84f85-5051-57a8-b962-eae212573609","slug":"si","display_name":"Human sucrase-isomaltase / SI","entity_type_key":"protein"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":3,"notes":""}]},"contexts":[{"dimension":"availability_state","value_text":"machinery_impairment","comparator":null,"unit":null,"notes":"Imported condition classification; unverified.","entity":null},{"dimension":"dose","value_text":"Yeast sucrase preparation, 6000 IU/mg protein; full strength and 1:10, 1:100, 1:1000 dilutions; >15 kg received 2 mL; lower-weight dose volume missing from accessed abstract","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"duration","value_text":"Single-dose breath tests; four 10-day dose periods","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"evidence_access","value_text":"Primary abstract/metadata; unrecovered methods explicitly retained.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"evidence_scope","value_text":"literature_reviewed; source-specific curation","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"28 children aged 5 months to 11 years with congenital sucrase-isomaltase deficiency; randomized double-blind trial","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure_scope","value_text":"Drug rescue of human genetic digestive impairment","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Enzyme replacement in diagnosed CSID, not sucrose supplementation for a nutrient deficiency. Exact sucrose challenge amount and lower-weight volume unrecovered. Vomiting did not differ; wheezing occurred in one child with asthma. Not prescribing guidance.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Sucrose chapter; direct sucrose observations are distinguished from shared component metabolism.","comparator":null,"unit":null,"notes":"","entity":{"slug":"sucrose","display_name":"Sucrose","entity_type_key":"small_molecule"}},{"dimension":"organism","value_text":"28 children aged 5 months to 11 years with congenital sucrase-isomaltase deficiency; randomized double-blind trial","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"Sacrosidase, with or without milk, reduced breath hydrogen after sucrose compared with placebo in children with CSID.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"Sacrosidase therapy for congenital sucrase-isomaltase deficiency. (1999). https://pubmed.ncbi.nlm.nih.gov/9932843/ DOI: 10.1097/00005176-199902000-00008","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"route","value_text":"Oral enzyme with sucrose challenge or normal carbohydrate-containing diet","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue","value_text":"Intestinal sucrose handling and stool/symptom outcomes","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"trigger_kind","value_text":"machinery_impairment","comparator":null,"unit":null,"notes":"Imported condition classification; unverified.","entity":null}],"evidence":[{"id":"3dca6fd3-b86f-5eca-8b74-00b926862272","evidence_kind":"source_excerpt","locator":"Lines 163-173","start_line":163,"end_line":173,"excerpt":"## sucrose-sacrosidase-hydrogen\nSacrosidase, with or without milk, reduced breath hydrogen after sucrose compared with placebo in children with CSID.\nModel/species: 28 children aged 5 months to 11 years with congenital sucrase-isomaltase deficiency; randomized double-blind trial\nTissue: Intestinal sucrose handling and stool/symptom outcomes\nExposure: Yeast sucrase preparation, 6000 IU/mg protein; full strength and 1:10, 1:100, 1:1000 dilutions; >15 kg received 2 mL; lower-weight dose volume missing from accessed abstract\nRoute: Oral enzyme with sucrose challenge or normal carbohydrate-containing diet\nDuration: Single-dose breath tests; four 10-day dose periods\nExposure scope: Drug rescue of human genetic digestive impairment\nLimits: Enzyme replacement in diagnosed CSID, not sucrose supplementation for a nutrient deficiency. Exact sucrose challenge amount and lower-weight volume unrecovered. Vomiting did not differ; wheezing occurred in one child with asthma. Not prescribing guidance.\nReference: Sacrosidase therapy for congenital sucrase-isomaltase deficiency. (1999). https://pubmed.ncbi.nlm.nih.gov/9932843/ DOI: 10.1097/00005176-199902000-00008\nAccess: Primary abstract/metadata; unrecovered methods explicitly retained.","model_system":"28 children aged 5 months to 11 years with congenital sucrase-isomaltase deficiency; randomized double-blind trial","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Exact original curation span, not a publisher quotation; provenance retained.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"8e24ddf4-84ee-57b4-9fd8-093547432ece","stable_key":"import-c932089b-ebc9-5f39-b2e5-84af74f9f6d0","title":"Sucrose: mechanism of action and metabolic impact (2026-09-20)","document_type":"imported_text","citation_label":"Original AI-assisted source-specific sucrose curation with shared canonical claims retained by identity. Primary-study citations, negative findings, exposure details and limitations preserved. Not publisher full text.","file_path":"","sha256":"5e68ccbade7a80fc03778495756f0eeeeba5038cd10d5bef8e33cb1e93e4b044","revision_id":"6edb8ffc-11c5-5cd9-852c-85adb71165a8","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}