Human post-meal zeaxanthin response: molecular mechanisms & dependencies

How nutrients influence it

Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.

Human evidence only

How nutrients reach it in more than one step

Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.

Tracing routes…

What it does

Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.

Recorded relationships

What acts on it

J-aggregated dipalmitate gave a 23% higher AUC estimate than H-aggregated free pigment, with P=0.064.
J-aggregated zeaxanthin dipalmitate test formulation → Human post-meal zeaxanthin response source_derived_draftungraded
Experimental context and source evidence
evidence_span
{"source_cache": "artifacts/zeaxanthin-research/29185931.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "3db71b8dc1b111c999db31427237d2296afb9024060396a63b2b2bc4d9bbcd37", "start_char": 0, "end_char": 1785, "text_sha256": "3db71b8dc1b111c999db31427237d2296afb9024060396a63b2b2bc4d9bbcd37"}
experimental_model
Randomized two-way crossover and simulated digestion
exposure
10 mg free-zeaxanthin equivalents in H-aggregated free or J-aggregated dipalmitate formulations
limitations
The 23% higher AUC estimate had P=0.064 and did not meet 0.05; aggregation and esterification changed together.
nutrient_topic
Zeaxanthin research collection; topical membership is not evidence of a direct dietary effect. · Dietary (3R,3-prime-R)-zeaxanthin
organism
16 human participants and in vitro digestion
plain_language
The estimate favored one formulation, but statistical uncertainty remained.
primary_references
[zeaxanthin-p29185931] Effect of aggregation form on bioavailability of zeaxanthin in humans: a randomised cross-over study. (2017). https://pubmed.ncbi.nlm.nih.gov/29185931/ DOI: 10.1017/s0007114517002653
tissue_or_cell_type
TAG-rich lipoprotein response
Zeaxanthin: metabolism, signaling and nutrient connections (2026-09-17) · lines 821–832
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Randomized two-way crossover and simulated digestion · source_derived_draft · unverified_draft
### zeaxanthin-aggregation-trend J-aggregated dipalmitate gave a 23% higher AUC estimate than H-aggregated free pigment, with P=0.064. Condition category: normal nutrient_topic: Zeaxanthin research collection; topical membership is not evidence of a direct dietary effect. plain_language: The estimate favored one formulation, but statistical uncertainty remained. organism: 16 human participants and in vitro digestion tissue_or_cell_type: TAG-rich lipoprotein response experimental_model: Randomized two-way crossover and simulated digestion limitations: The 23% higher AUC estimate had P=0.064 and did not meet 0.05; aggregation and esterification changed together. exposure: 10 mg free-zeaxanthin equivalents in H-aggregated free or J-aggregated dipalmitate formulations evidence_span: {"source_cache": "artifacts/zeaxanthin-research/29185931.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "3db71b8dc1b111c999db31427237d2296afb9024060396a63b2b2bc4d9bbcd37", "start_char": 0, "end_char": 1785, "text_sha256": "3db71b8dc1b111c999db31427237d2296afb9024060396a63b2b2bc4d9bbcd37"} [zeaxanthin-p29185931] Effect of aggregation form on bioavailability of zeaxanthin in humans: a randomised cross-over study. (2017). https://pubmed.ncbi.nlm.nih.gov/29185931/ DOI: 10.1017/s0007114517002653
Complete structured claim and evidence
The dipalmitate preparation produced a higher plasma-response AUC than the free preparation in this crossover trial.
Zeaxanthin dipalmitate → Human post-meal zeaxanthin response source_derived_draftungraded
Experimental context and source evidence
evidence_span
{"source_cache": "artifacts/zeaxanthin-research/15137922.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "6410a0f5d52cf32390f90f59a7b17d2340a889f888836129f8a93482ca055be0", "start_char": 0, "end_char": 1847, "text_sha256": "6410a0f5d52cf32390f90f59a7b17d2340a889f888836129f8a93482ca055be0"}
experimental_model
Randomized single-blind crossover meal trial
exposure
5 mg free zeaxanthin equivalents as free pigment or dipalmitate in yoghurt/breakfast; 24 h sampling
limitations
Meal- and formulation-specific response; no proof of disease prevention or an optimal universal formulation.
nutrient_topic
Zeaxanthin research collection; topical membership is not evidence of a direct dietary effect. · Dietary (3R,3-prime-R)-zeaxanthin
organism
12 volunteers
plain_language
Chemical form changed the measured response to this meal.
primary_references
[zeaxanthin-p15137922] Comparison of plasma responses in human subjects after the ingestion of 3R,3R'-zeaxanthin dipalmitate from wolfberry (Lycium barbarum) and non-esterified 3R,3R'-zeaxanthin using chiral high-performance liquid chromatography. (2004). https://pubmed.ncbi.nlm.nih.gov/15137922/ DOI: 10.1079/bjn20041105
tissue_or_cell_type
Plasma response
Zeaxanthin: metabolism, signaling and nutrient connections (2026-09-17) · lines 795–806
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Randomized single-blind crossover meal trial · source_derived_draft · unverified_draft
### zeaxanthin-ester-human-response The dipalmitate preparation produced a higher plasma-response AUC than the free preparation in this crossover trial. Condition category: normal nutrient_topic: Zeaxanthin research collection; topical membership is not evidence of a direct dietary effect. plain_language: Chemical form changed the measured response to this meal. organism: 12 volunteers tissue_or_cell_type: Plasma response experimental_model: Randomized single-blind crossover meal trial limitations: Meal- and formulation-specific response; no proof of disease prevention or an optimal universal formulation. exposure: 5 mg free zeaxanthin equivalents as free pigment or dipalmitate in yoghurt/breakfast; 24 h sampling evidence_span: {"source_cache": "artifacts/zeaxanthin-research/15137922.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "6410a0f5d52cf32390f90f59a7b17d2340a889f888836129f8a93482ca055be0", "start_char": 0, "end_char": 1847, "text_sha256": "6410a0f5d52cf32390f90f59a7b17d2340a889f888836129f8a93482ca055be0"} [zeaxanthin-p15137922] Comparison of plasma responses in human subjects after the ingestion of 3R,3R'-zeaxanthin dipalmitate from wolfberry (Lycium barbarum) and non-esterified 3R,3R'-zeaxanthin using chiral high-performance liquid chromatography. (2004). https://pubmed.ncbi.nlm.nih.gov/15137922/ DOI: 10.1079/bjn20041105
Complete structured claim and evidence

The events it takes part in

A mechanism often involves more than two components. These are the full events, with every participant and its role.

Situations it appears in

Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.

In the sources

Preserved passages that mention this component, quoted exactly. Open one to read it in context.

Open hypotheses

Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.

This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.

Human post-meal zeaxanthin response