Component
Intracellular cAMP in human neutrophils
Experimental species, exposure and limitations are retained on each claim.
2 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
What acts on it
6-Gingerol pretreatment increased the forskolin-stimulated intracellular cAMP response in human neutrophils.
Experimental context and source evidence
- dose
- 6-Gingerol 10 micromolar followed by forskolin 100 micromolar
- duration
- 30 min gingerol followed by 10 min forskolin
- evidence_access
- Primary open full text, results, figure legends and methods, plus PubMed metadata.
- evidence_scope
- literature_reviewed; model-specific source-derived curation, not universally established human effects
- experimental_model
- Neutrophils isolated from healthy human donors
- limitations
- Potentiation of a forskolin-stimulated signal is not proof of the same magnitude under basal conditions.
- nutrient_topic
- Gingerols collection; each molecular form and experimental preparation remains explicit. · Gingerols
- organism
- Neutrophils isolated from healthy human donors
- plain_language
- 6-Gingerol pretreatment increased the forskolin-stimulated intracellular cAMP response in human neutrophils.
- primary_references
- Antineutrophil properties of natural gingerols in models of lupus. (2021). https://pubmed.ncbi.nlm.nih.gov/33373329/ DOI: 10.1172/jci.insight.138385
- route
- Ex vivo exposure
- tissue
- Human neutrophil cytosol
Gingerols: mechanisms, molecular forms and cross-actor connections (2026-09-20) · lines 459–468
Original AI-assisted curation of thirteen primary research papers; study-specific PubMed/DOI links and limitations retained. Not publisher full text. · supports · Neutrophils isolated from healthy human donors · source_derived_draft · unverified_draft
## gingerols-6-neutrophil-camp 6-Gingerol pretreatment increased the forskolin-stimulated intracellular cAMP response in human neutrophils. Model/species: Neutrophils isolated from healthy human donors Tissue: Human neutrophil cytosol Exposure: 6-Gingerol 10 micromolar followed by forskolin 100 micromolar Route: Ex vivo exposure Duration: 30 min gingerol followed by 10 min forskolin Limits: Potentiation of a forskolin-stimulated signal is not proof of the same magnitude under basal conditions. Primary reference: Antineutrophil properties of natural gingerols in models of lupus. (2021). https://pubmed.ncbi.nlm.nih.gov/33373329/ DOI: 10.1172/jci.insight.138385 Access: Primary open full text, results, figure legends and methods, plus PubMed metadata.
Complete structured claim and evidenceSeven days of whole-ginger extract intake was associated with higher neutrophil cAMP in the healthy-volunteer cohorts.
Experimental context and source evidence
- dose
- 100 mg whole-ginger extract, approximately 20 mg gingerols daily
- duration
- 7 days; sampling baseline, day 7 and day 14
- evidence_access
- Primary open full text, results, figure legends and methods, plus PubMed metadata.
- evidence_scope
- literature_reviewed; model-specific source-derived curation, not universally established human effects
- experimental_model
- Healthy volunteers: 9 Michigan participants and 8 Colorado participants
- limitations
- Small before/after cohorts without placebo; shared research program, not two independent laboratory replications. Individual gingerol attribution and clinical disease benefit are unproven.
- nutrient_topic
- Gingerols collection; each molecular form and experimental preparation remains explicit. · Gingerols
- organism
- Healthy volunteers: 9 Michigan participants and 8 Colorado participants
- plain_language
- Seven days of whole-ginger extract intake was associated with higher neutrophil cAMP in the healthy-volunteer cohorts.
- primary_references
- Ginger intake suppresses neutrophil extracellular trap formation in autoimmune mice and healthy humans. (2023). https://pubmed.ncbi.nlm.nih.gov/37737262/ DOI: 10.1172/jci.insight.172011
- route
- Oral mixed extract
- tissue
- Blood neutrophils, PBMCs and plasma
Gingerols: mechanisms, molecular forms and cross-actor connections (2026-09-20) · lines 492–501
Original AI-assisted curation of thirteen primary research papers; study-specific PubMed/DOI links and limitations retained. Not publisher full text. · supports · Healthy volunteers: 9 Michigan participants and 8 Colorado participants · source_derived_draft · unverified_draft
## gingerols-human-extract-camp Seven days of whole-ginger extract intake was associated with higher neutrophil cAMP in the healthy-volunteer cohorts. Model/species: Healthy volunteers: 9 Michigan participants and 8 Colorado participants Tissue: Blood neutrophils, PBMCs and plasma Exposure: 100 mg whole-ginger extract, approximately 20 mg gingerols daily Route: Oral mixed extract Duration: 7 days; sampling baseline, day 7 and day 14 Limits: Small before/after cohorts without placebo; shared research program, not two independent laboratory replications. Individual gingerol attribution and clinical disease benefit are unproven. Primary reference: Ginger intake suppresses neutrophil extracellular trap formation in autoimmune mice and healthy humans. (2023). https://pubmed.ncbi.nlm.nih.gov/37737262/ DOI: 10.1172/jci.insight.172011 Access: Primary open full text, results, figure legends and methods, plus PubMed metadata.
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.