Component

Ginger extract in the 2023 human neutrophil pilot study

Pureveda Activ Digest containing Ginactiv, supplied by Aurea Biolabs; 100 mg extract with approximately 20 mg gingerols daily for seven days. Whole extract, not a single purified compound.

4 recorded relationships. Experimental role, claim status and evidence remain attached to each record.

Read recorded mechanisms Open recursive mind map

How nutrients influence it

Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.

How nutrients reach it in more than one step

Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.

Tracing routes…

What it does

Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.

Recorded relationships

What it acts on

  1. Seven days of whole-ginger extract intake was associated with higher neutrophil cAMP in the healthy-volunteer cohorts.

    Ginger extract in the 2023 human neutrophil pilot study → Intracellular cAMP in human neutrophils source_derived_draftungraded
    Experimental context and source evidence
    dose
    100 mg whole-ginger extract, approximately 20 mg gingerols daily
    duration
    7 days; sampling baseline, day 7 and day 14
    evidence_access
    Primary open full text, results, figure legends and methods, plus PubMed metadata.
    evidence_scope
    literature_reviewed; model-specific source-derived curation, not universally established human effects
    experimental_model
    Healthy volunteers: 9 Michigan participants and 8 Colorado participants
    limitations
    Small before/after cohorts without placebo; shared research program, not two independent laboratory replications. Individual gingerol attribution and clinical disease benefit are unproven.
    nutrient_topic
    Gingerols collection; each molecular form and experimental preparation remains explicit. · Gingerols
    organism
    Healthy volunteers: 9 Michigan participants and 8 Colorado participants
    plain_language
    Seven days of whole-ginger extract intake was associated with higher neutrophil cAMP in the healthy-volunteer cohorts.
    primary_references
    Ginger intake suppresses neutrophil extracellular trap formation in autoimmune mice and healthy humans. (2023). https://pubmed.ncbi.nlm.nih.gov/37737262/ DOI: 10.1172/jci.insight.172011
    route
    Oral mixed extract
    tissue
    Blood neutrophils, PBMCs and plasma

    Gingerols: mechanisms, molecular forms and cross-actor connections (2026-09-20) · lines 492–501

    Original AI-assisted curation of thirteen primary research papers; study-specific PubMed/DOI links and limitations retained. Not publisher full text. · supports · Healthy volunteers: 9 Michigan participants and 8 Colorado participants · source_derived_draft · unverified_draft

    ## gingerols-human-extract-camp Seven days of whole-ginger extract intake was associated with higher neutrophil cAMP in the healthy-volunteer cohorts. Model/species: Healthy volunteers: 9 Michigan participants and 8 Colorado participants Tissue: Blood neutrophils, PBMCs and plasma Exposure: 100 mg whole-ginger extract, approximately 20 mg gingerols daily Route: Oral mixed extract Duration: 7 days; sampling baseline, day 7 and day 14 Limits: Small before/after cohorts without placebo; shared research program, not two independent laboratory replications. Individual gingerol attribution and clinical disease benefit are unproven. Primary reference: Ginger intake suppresses neutrophil extracellular trap formation in autoimmune mice and healthy humans. (2023). https://pubmed.ncbi.nlm.nih.gov/37737262/ DOI: 10.1172/jci.insight.172011 Access: Primary open full text, results, figure legends and methods, plus PubMed metadata.
    Complete structured claim and evidence

  2. Ginger intake was associated with lower circulating NET-associated markers in the pilot cohorts.

    Ginger extract in the 2023 human neutrophil pilot study → Human plasma NET-associated markers source_derived_draftungraded
    Experimental context and source evidence
    dose
    100 mg whole-ginger extract, approximately 20 mg gingerols daily
    duration
    7 days; sampling baseline, day 7 and day 14
    evidence_access
    Primary open full text, results, figure legends and methods, plus PubMed metadata.
    evidence_scope
    literature_reviewed; model-specific source-derived curation, not universally established human effects
    experimental_model
    Healthy volunteers: 9 Michigan participants and 8 Colorado participants
    limitations
    Small before/after cohorts without placebo; shared research program, not two independent laboratory replications. Individual gingerol attribution and clinical disease benefit are unproven.
    nutrient_topic
    Gingerols collection; each molecular form and experimental preparation remains explicit. · Gingerols
    organism
    Healthy volunteers: 9 Michigan participants and 8 Colorado participants
    plain_language
    Ginger intake was associated with lower circulating NET-associated markers in the pilot cohorts.
    primary_references
    Ginger intake suppresses neutrophil extracellular trap formation in autoimmune mice and healthy humans. (2023). https://pubmed.ncbi.nlm.nih.gov/37737262/ DOI: 10.1172/jci.insight.172011
    route
    Oral mixed extract
    tissue
    Blood neutrophils, PBMCs and plasma

    Gingerols: mechanisms, molecular forms and cross-actor connections (2026-09-20) · lines 525–534

    Original AI-assisted curation of thirteen primary research papers; study-specific PubMed/DOI links and limitations retained. Not publisher full text. · supports · Healthy volunteers: 9 Michigan participants and 8 Colorado participants · source_derived_draft · unverified_draft

    ## gingerols-human-extract-net-markers Ginger intake was associated with lower circulating NET-associated markers in the pilot cohorts. Model/species: Healthy volunteers: 9 Michigan participants and 8 Colorado participants Tissue: Blood neutrophils, PBMCs and plasma Exposure: 100 mg whole-ginger extract, approximately 20 mg gingerols daily Route: Oral mixed extract Duration: 7 days; sampling baseline, day 7 and day 14 Limits: Small before/after cohorts without placebo; shared research program, not two independent laboratory replications. Individual gingerol attribution and clinical disease benefit are unproven. Primary reference: Ginger intake suppresses neutrophil extracellular trap formation in autoimmune mice and healthy humans. (2023). https://pubmed.ncbi.nlm.nih.gov/37737262/ DOI: 10.1172/jci.insight.172011 Access: Primary open full text, results, figure legends and methods, plus PubMed metadata.
    Complete structured claim and evidence

  3. Neutrophils collected after ginger intake showed reduced ex vivo NET responses to disease-relevant stimuli.

    Ginger extract in the 2023 human neutrophil pilot study → NET formation by human neutrophils source_derived_draftungraded
    Experimental context and source evidence
    dose
    100 mg whole-ginger extract, approximately 20 mg gingerols daily
    duration
    7 days; sampling baseline, day 7 and day 14
    evidence_access
    Primary open full text, results, figure legends and methods, plus PubMed metadata.
    evidence_scope
    literature_reviewed; model-specific source-derived curation, not universally established human effects
    experimental_model
    Healthy volunteers: 9 Michigan participants and 8 Colorado participants
    limitations
    Small before/after cohorts without placebo; shared research program, not two independent laboratory replications. Individual gingerol attribution and clinical disease benefit are unproven.
    nutrient_topic
    Gingerols collection; each molecular form and experimental preparation remains explicit. · Gingerols
    organism
    Healthy volunteers: 9 Michigan participants and 8 Colorado participants
    plain_language
    Neutrophils collected after ginger intake showed reduced ex vivo NET responses to disease-relevant stimuli.
    primary_references
    Ginger intake suppresses neutrophil extracellular trap formation in autoimmune mice and healthy humans. (2023). https://pubmed.ncbi.nlm.nih.gov/37737262/ DOI: 10.1172/jci.insight.172011
    route
    Oral mixed extract
    tissue
    Blood neutrophils, PBMCs and plasma

    Gingerols: mechanisms, molecular forms and cross-actor connections (2026-09-20) · lines 514–523

    Original AI-assisted curation of thirteen primary research papers; study-specific PubMed/DOI links and limitations retained. Not publisher full text. · supports · Healthy volunteers: 9 Michigan participants and 8 Colorado participants · source_derived_draft · unverified_draft

    ## gingerols-human-extract-netosis Neutrophils collected after ginger intake showed reduced ex vivo NET responses to disease-relevant stimuli. Model/species: Healthy volunteers: 9 Michigan participants and 8 Colorado participants Tissue: Blood neutrophils, PBMCs and plasma Exposure: 100 mg whole-ginger extract, approximately 20 mg gingerols daily Route: Oral mixed extract Duration: 7 days; sampling baseline, day 7 and day 14 Limits: Small before/after cohorts without placebo; shared research program, not two independent laboratory replications. Individual gingerol attribution and clinical disease benefit are unproven. Primary reference: Ginger intake suppresses neutrophil extracellular trap formation in autoimmune mice and healthy humans. (2023). https://pubmed.ncbi.nlm.nih.gov/37737262/ DOI: 10.1172/jci.insight.172011 Access: Primary open full text, results, figure legends and methods, plus PubMed metadata.
    Complete structured claim and evidence

  4. The ginger pilot study did not find a significant increase in PBMC cAMP.

    Ginger extract in the 2023 human neutrophil pilot study → Intracellular cAMP in human peripheral blood mononuclear cells source_derived_draftungraded
    Experimental context and source evidence
    dose
    100 mg whole-ginger extract, approximately 20 mg gingerols daily
    duration
    7 days; sampling baseline, day 7 and day 14
    evidence_access
    Primary open full text, results, figure legends and methods, plus PubMed metadata.
    evidence_scope
    literature_reviewed; model-specific source-derived curation, not universally established human effects
    experimental_model
    Healthy volunteers: 9 Michigan participants and 8 Colorado participants
    limitations
    Small before/after cohorts without placebo; shared research program, not two independent laboratory replications. Individual gingerol attribution and clinical disease benefit are unproven.
    nutrient_topic
    Gingerols collection; each molecular form and experimental preparation remains explicit. · Gingerols
    organism
    Healthy volunteers: 9 Michigan participants and 8 Colorado participants
    plain_language
    The ginger pilot study did not find a significant increase in PBMC cAMP.
    primary_references
    Ginger intake suppresses neutrophil extracellular trap formation in autoimmune mice and healthy humans. (2023). https://pubmed.ncbi.nlm.nih.gov/37737262/ DOI: 10.1172/jci.insight.172011
    route
    Oral mixed extract
    tissue
    Blood neutrophils, PBMCs and plasma

    Gingerols: mechanisms, molecular forms and cross-actor connections (2026-09-20) · lines 503–512

    Original AI-assisted curation of thirteen primary research papers; study-specific PubMed/DOI links and limitations retained. Not publisher full text. · supports · Healthy volunteers: 9 Michigan participants and 8 Colorado participants · source_derived_draft · unverified_draft

    ## gingerols-human-extract-pbmc-null The ginger pilot study did not find a significant increase in PBMC cAMP. Model/species: Healthy volunteers: 9 Michigan participants and 8 Colorado participants Tissue: Blood neutrophils, PBMCs and plasma Exposure: 100 mg whole-ginger extract, approximately 20 mg gingerols daily Route: Oral mixed extract Duration: 7 days; sampling baseline, day 7 and day 14 Limits: Small before/after cohorts without placebo; shared research program, not two independent laboratory replications. Individual gingerol attribution and clinical disease benefit are unproven. Primary reference: Ginger intake suppresses neutrophil extracellular trap formation in autoimmune mice and healthy humans. (2023). https://pubmed.ncbi.nlm.nih.gov/37737262/ DOI: 10.1172/jci.insight.172011 Access: Primary open full text, results, figure legends and methods, plus PubMed metadata.
    Complete structured claim and evidence

In the sources

Preserved passages that mention this component, quoted exactly. Open one to read it in context.

    This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.

    Evidence, AI assistance and curation standards