{"id":"764b7f2c-9793-5863-a49e-4c6dd47b825f","stable_key":"fd7915ff-856d-56c2-a118-4989693a7644:gingerols-human-extract-pbmc-null","predicate":"no_detected_change","statement":"The ginger pilot study did not find a significant increase in PBMC cAMP.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"neutral","is_public":true,"mechanism_event_id":"3a942226-cc51-545f-8cc3-b9d860ab8181","mechanism_event_label":"The ginger pilot study did not find a significant increase in PBMC cAMP.","subject":{"id":"32d00394-7ca3-541c-823e-55a9027c567f","slug":"ginger-2023-neutrophil-preparation","display_name":"Ginger extract in the 2023 human neutrophil pilot study","entity_type_key":"small_molecule"},"object":{"id":"117e8f01-fd6c-50f1-8e49-5dcf74a55524","slug":"human-pbmc-intracellular-camp","display_name":"Intracellular cAMP in human peripheral blood mononuclear cells","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"3a942226-cc51-545f-8cc3-b9d860ab8181","stable_key":"fd7915ff-856d-56c2-a118-4989693a7644:gingerols-human-extract-pbmc-null-event","event_type":"observed_relationship","label":"The ginger pilot study did not find a significant increase in PBMC cAMP.","description":"The ginger pilot study did not find a significant increase in PBMC cAMP.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"32d00394-7ca3-541c-823e-55a9027c567f","slug":"ginger-2023-neutrophil-preparation","display_name":"Ginger extract in the 2023 human neutrophil pilot study","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"117e8f01-fd6c-50f1-8e49-5dcf74a55524","slug":"human-pbmc-intracellular-camp","display_name":"Intracellular cAMP in human peripheral blood mononuclear cells","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"9cc3323e-3a7f-5be5-91ae-78dab284fb81","slug":"cyclic-amp","display_name":"Cyclic adenosine monophosphate","entity_type_key":"small_molecule"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""}]},"contexts":[{"dimension":"dose","value_text":"100 mg whole-ginger extract, approximately 20 mg gingerols daily","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"duration","value_text":"7 days; sampling baseline, day 7 and day 14","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"evidence_access","value_text":"Primary open full text, results, figure legends and methods, plus PubMed metadata.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"evidence_scope","value_text":"literature_reviewed; model-specific source-derived curation, not universally established human effects","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Healthy volunteers: 9 Michigan participants and 8 Colorado participants","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Small before/after cohorts without placebo; shared research program, not two independent laboratory replications. Individual gingerol attribution and clinical disease benefit are unproven.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Gingerols collection; each molecular form and experimental preparation remains explicit.","comparator":null,"unit":null,"notes":"","entity":{"slug":"gingerols","display_name":"Gingerols","entity_type_key":"small_molecule"}},{"dimension":"organism","value_text":"Healthy volunteers: 9 Michigan participants and 8 Colorado participants","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"The ginger pilot study did not find a significant increase in PBMC cAMP.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"Ginger intake suppresses neutrophil extracellular trap formation in autoimmune mice and healthy humans. (2023). https://pubmed.ncbi.nlm.nih.gov/37737262/ DOI: 10.1172/jci.insight.172011","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"route","value_text":"Oral mixed extract","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue","value_text":"Blood neutrophils, PBMCs and plasma","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"9d6e801b-5c14-5cdf-a614-c9f94f4ce5a2","evidence_kind":"source_excerpt","locator":"Lines 503-512","start_line":503,"end_line":512,"excerpt":"## gingerols-human-extract-pbmc-null\nThe ginger pilot study did not find a significant increase in PBMC cAMP.\nModel/species: Healthy volunteers: 9 Michigan participants and 8 Colorado participants\nTissue: Blood neutrophils, PBMCs and plasma\nExposure: 100 mg whole-ginger extract, approximately 20 mg gingerols daily\nRoute: Oral mixed extract\nDuration: 7 days; sampling baseline, day 7 and day 14\nLimits: Small before/after cohorts without placebo; shared research program, not two independent laboratory replications. Individual gingerol attribution and clinical disease benefit are unproven.\nPrimary reference: Ginger intake suppresses neutrophil extracellular trap formation in autoimmune mice and healthy humans. (2023). https://pubmed.ncbi.nlm.nih.gov/37737262/ DOI: 10.1172/jci.insight.172011\nAccess: Primary open full text, results, figure legends and methods, plus PubMed metadata.","model_system":"Healthy volunteers: 9 Michigan participants and 8 Colorado participants","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Exact archived synthesis span with its primary citation; original paraphrase, not a claimed publisher quotation.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"1107d60b-8e2d-55d7-8f5d-5612c49aa7dc","stable_key":"import-fd7915ff-856d-56c2-a118-4989693a7644","title":"Gingerols: mechanisms, molecular forms and cross-actor connections (2026-09-20)","document_type":"imported_text","citation_label":"Original AI-assisted curation of thirteen primary research papers; study-specific PubMed/DOI links and limitations retained. Not publisher full text.","file_path":"","sha256":"96d1b7b04445eecd0eac1738e0c80cb6308509ecdfc3b5fc6be67ae2218cbb2b","revision_id":"de6e70ff-0e52-5c26-bd3a-54fca2085a86","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}