{"id":"bce291ab-8302-543a-8d6b-227a8669f367","stable_key":"fd7915ff-856d-56c2-a118-4989693a7644:gingerols-6-neutrophil-camp","predicate":"potentiates","statement":"6-Gingerol pretreatment increased the forskolin-stimulated intracellular cAMP response in human neutrophils.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"positive","is_public":true,"mechanism_event_id":"35ff7940-14cb-588d-9938-3f51f7619eae","mechanism_event_label":"6-Gingerol pretreatment increased the forskolin-stimulated intracellular cAMP response in human neutrophils.","subject":{"id":"837fdd65-c1eb-52e0-a724-42a1e9065c82","slug":"6-gingerol","display_name":"6-Gingerol","entity_type_key":"small_molecule"},"object":{"id":"696f3731-910e-5b2c-822e-b0a1c1e95a8e","slug":"human-neutrophil-intracellular-camp","display_name":"Intracellular cAMP in human neutrophils","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"35ff7940-14cb-588d-9938-3f51f7619eae","stable_key":"fd7915ff-856d-56c2-a118-4989693a7644:gingerols-6-neutrophil-camp-event","event_type":"observed_relationship","label":"6-Gingerol pretreatment increased the forskolin-stimulated intracellular cAMP response in human neutrophils.","description":"6-Gingerol pretreatment increased the forskolin-stimulated intracellular cAMP response in human neutrophils.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"837fdd65-c1eb-52e0-a724-42a1e9065c82","slug":"6-gingerol","display_name":"6-Gingerol","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"696f3731-910e-5b2c-822e-b0a1c1e95a8e","slug":"human-neutrophil-intracellular-camp","display_name":"Intracellular cAMP in human neutrophils","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"1a29cb8b-2916-5c74-a3d7-b2ae61fd37de","slug":"forskolin","display_name":"Forskolin","entity_type_key":"small_molecule"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""},{"entity":{"id":"9cc3323e-3a7f-5be5-91ae-78dab284fb81","slug":"cyclic-amp","display_name":"Cyclic adenosine monophosphate","entity_type_key":"small_molecule"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":3,"notes":""}]},"contexts":[{"dimension":"dose","value_text":"6-Gingerol 10 micromolar followed by forskolin 100 micromolar","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"duration","value_text":"30 min gingerol followed by 10 min forskolin","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"evidence_access","value_text":"Primary open full text, results, figure legends and methods, plus PubMed metadata.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"evidence_scope","value_text":"literature_reviewed; model-specific source-derived curation, not universally established human effects","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Neutrophils isolated from healthy human donors","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Potentiation of a forskolin-stimulated signal is not proof of the same magnitude under basal conditions.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Gingerols collection; each molecular form and experimental preparation remains explicit.","comparator":null,"unit":null,"notes":"","entity":{"slug":"gingerols","display_name":"Gingerols","entity_type_key":"small_molecule"}},{"dimension":"organism","value_text":"Neutrophils isolated from healthy human donors","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"6-Gingerol pretreatment increased the forskolin-stimulated intracellular cAMP response in human neutrophils.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"Antineutrophil properties of natural gingerols in models of lupus. (2021). https://pubmed.ncbi.nlm.nih.gov/33373329/ DOI: 10.1172/jci.insight.138385","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"route","value_text":"Ex vivo exposure","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue","value_text":"Human neutrophil cytosol","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"f26f8540-b028-5958-b63e-ae148800a481","evidence_kind":"source_excerpt","locator":"Lines 459-468","start_line":459,"end_line":468,"excerpt":"## gingerols-6-neutrophil-camp\n6-Gingerol pretreatment increased the forskolin-stimulated intracellular cAMP response in human neutrophils.\nModel/species: Neutrophils isolated from healthy human donors\nTissue: Human neutrophil cytosol\nExposure: 6-Gingerol 10 micromolar followed by forskolin 100 micromolar\nRoute: Ex vivo exposure\nDuration: 30 min gingerol followed by 10 min forskolin\nLimits: Potentiation of a forskolin-stimulated signal is not proof of the same magnitude under basal conditions.\nPrimary reference: Antineutrophil properties of natural gingerols in models of lupus. 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