Component
Human post-methionine-load plasma total homocysteine response
Human post-methionine-load plasma total homocysteine response. Species, exposure and limitations are retained in each linked claim.
2 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
What acts on it
After two weeks, the post-methionine-load homocysteine rise was 29% lower than with placebo.
Experimental context and source evidence
- evidence_span
- {"source_cache": "artifacts/choline-research/16002808.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "ad206000c96c52d280ac135c03d531122121a82c436dce40c7d13e55d0976ae1", "start_char": 0, "end_char": 1797, "text_sha256": "ad206000c96c52d280ac135c03d531122121a82c436dce40c7d13e55d0976ae1"}
- experimental_model
- Randomized crossover feeding trial
- exposure
- About 2.6 g choline/day as PC versus matched placebo oil for two weeks; methionine-load testing
- limitations
- High experimental intake and biomarker endpoint; no cardiovascular-event benefit was tested.
- nutrient_topic
- Choline research collection; topical membership is not evidence of a direct dietary effect. · Choline
- organism
- Human
- plain_language
- The response to a methionine challenge also changed.
- primary_references
- [choline-p16002808] Choline supplemented as phosphatidylcholine decreases fasting and postmethionine-loading plasma homocysteine concentrations in healthy men. (2005). https://pubmed.ncbi.nlm.nih.gov/16002808/ DOI: 10.1093/ajcn.82.1.111
- tissue_or_cell_type
- 26 men with mildly elevated plasma homocysteine
Choline: metabolism, signaling and nutrient connections (2026-09-17) · lines 1088–1099
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Randomized crossover feeding trial · source_derived_draft · unverified_draft
### choline-pc-hcy-load After two weeks, the post-methionine-load homocysteine rise was 29% lower than with placebo. Condition category: normal nutrient_topic: Choline research collection; topical membership is not evidence of a direct dietary effect. plain_language: The response to a methionine challenge also changed. organism: Human tissue_or_cell_type: 26 men with mildly elevated plasma homocysteine experimental_model: Randomized crossover feeding trial limitations: High experimental intake and biomarker endpoint; no cardiovascular-event benefit was tested. exposure: About 2.6 g choline/day as PC versus matched placebo oil for two weeks; methionine-load testing evidence_span: {"source_cache": "artifacts/choline-research/16002808.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "ad206000c96c52d280ac135c03d531122121a82c436dce40c7d13e55d0976ae1", "start_char": 0, "end_char": 1797, "text_sha256": "ad206000c96c52d280ac135c03d531122121a82c436dce40c7d13e55d0976ae1"} [choline-p16002808] Choline supplemented as phosphatidylcholine decreases fasting and postmethionine-loading plasma homocysteine concentrations in healthy men. (2005). https://pubmed.ncbi.nlm.nih.gov/16002808/ DOI: 10.1093/ajcn.82.1.111
Complete structured claim and evidenceA 0.1 g/kg oral methionine load increased mean plasma homocysteine from 7.9 to 23.1 micromolar at four hours in 24 healthy volunteers.
Experimental context and source evidence
- availability_state
- biomarker_context Imported condition classification; unverified.
- evidence_access
- Primary abstract
- experimental_model
- Randomized crossover human loading study.
- limitations
- Challenge dose is not ordinary food intake; response depends on metabolism and context.
- nutrient_topic
- L-Methionine collection; species, compartment, exposure, co-substrates and manipulation remain explicit. · L-Methionine
- plain_language
- A large acute load challenges recycling and sulfur disposal.
- primary_references
- Hyperhomocysteinemia after an oral methionine load acutely impairs endothelial function in healthy adults. · 1998 · https://pubmed.ncbi.nlm.nih.gov/9799203/ · DOI 10.1161/01.cir.98.18.1848
- trigger_kind
- biomarker_context Imported condition classification; unverified.
L-Methionine: transport, methylation, sulfur metabolism and cross-nutrient mechanisms (2026-09-19) · lines 412–418
AI-assisted research curation; primary references, access levels and experimental limitations individually identified. Not publisher full text. · supports · Randomized crossover human loading study. · source_derived_draft · unverified_draft
## methionine-load-homocysteine A large acute load challenges recycling and sulfur disposal. A 0.1 g/kg oral methionine load increased mean plasma homocysteine from 7.9 to 23.1 micromolar at four hours in 24 healthy volunteers. Model: Randomized crossover human loading study. Limitations: Challenge dose is not ordinary food intake; response depends on metabolism and context. Evidence access: Primary abstract Hyperhomocysteinemia after an oral methionine load acutely impairs endothelial function in healthy adults. · 1998 · https://pubmed.ncbi.nlm.nih.gov/9799203/ · DOI 10.1161/01.cir.98.18.1848
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.