{"id":"70975f6a-ee89-5b0b-bfbd-09cd677e42f9","stable_key":"27e0c1cf-7726-5164-8b15-27a631584cd0:choline-pc-hcy-load","predicate":"reduces","statement":"After two weeks, the post-methionine-load homocysteine rise was 29% lower than with placebo.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"9f244725-d2b2-5d74-8a45-a78d4b2d84fa","mechanism_event_label":"The response to a methionine challenge also changed.","subject":{"id":"35adb31d-18cf-5997-9e73-8e5c54d84336","slug":"phosphatidylcholine-supplement","display_name":"Study-specific phosphatidylcholine supplements","entity_type_key":"chemical_species"},"object":{"id":"47175e14-42b1-50a5-94f2-578378206646","slug":"human-methionine-load-homocysteine","display_name":"Human post-methionine-load plasma total homocysteine response","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"9f244725-d2b2-5d74-8a45-a78d4b2d84fa","stable_key":"27e0c1cf-7726-5164-8b15-27a631584cd0:choline-pc-hcy-load-event","event_type":"observed_intervention","label":"The response to a methionine challenge also changed.","description":"After two weeks, the post-methionine-load homocysteine rise was 29% lower than with placebo.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"35adb31d-18cf-5997-9e73-8e5c54d84336","slug":"phosphatidylcholine-supplement","display_name":"Study-specific phosphatidylcholine supplements","entity_type_key":"chemical_species"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"47175e14-42b1-50a5-94f2-578378206646","slug":"human-methionine-load-homocysteine","display_name":"Human post-methionine-load plasma total homocysteine response","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""}]},"contexts":[{"dimension":"evidence_span","value_text":"{\"source_cache\": \"artifacts/choline-research/16002808.abstract.txt\", \"locator\": \"Primary indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"ad206000c96c52d280ac135c03d531122121a82c436dce40c7d13e55d0976ae1\", \"start_char\": 0, \"end_char\": 1797, \"text_sha256\": \"ad206000c96c52d280ac135c03d531122121a82c436dce40c7d13e55d0976ae1\"}","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Randomized crossover feeding trial","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure","value_text":"About 2.6 g choline/day as PC versus matched placebo oil for two weeks; methionine-load testing","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"High experimental intake and biomarker endpoint; no cardiovascular-event benefit was tested.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Choline research collection; topical membership is not evidence of a direct dietary effect.","comparator":null,"unit":null,"notes":"","entity":{"slug":"choline","display_name":"Choline","entity_type_key":"small_molecule"}},{"dimension":"organism","value_text":"Human","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"The response to a methionine challenge also changed.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[choline-p16002808] Choline supplemented as phosphatidylcholine decreases fasting and postmethionine-loading plasma homocysteine concentrations in healthy men. 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