Component

Human fecal butyrate concentration

Context-specific entity; species, compartment and exposure are stated on each claim.

3 recorded relationships. Experimental role, claim status and evidence remain attached to each record.

Read recorded mechanisms Open recursive mind map

How nutrients influence it

Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.

How nutrients reach it in more than one step

Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.

Tracing routes…

What it does

Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.

Recorded relationships

What acts on it

  1. In the 174-person two-week fiber study, resistant potato starch produced the greatest fecal SCFA/butyrate rise; resistant maize starch and inulin did not significantly increase fecal butyrate.

    Resistant potato starch preparation → Human fecal butyrate concentration source_derived_draftungraded
    Experimental context and source evidence
    evidence_access
    Primary abstract
    experimental_model
    Healthy young adults; four dietary interventions.
    limitations
    Fecal concentration is not a direct measure of total production or absorbed dose.
    nutrient_topic
    Butyrate collection; molecular form, preparation, species, exposure and manipulation remain explicit. · Butyrate
    plain_language
    Fiber type and the starting microbial community changed the response.
    primary_references
    Dynamics of Human Gut Microbiota and Short-Chain Fatty Acids in Response to Dietary Interventions with Three Fermentable Fibers. · 2019 · https://pubmed.ncbi.nlm.nih.gov/30696735/ · DOI 10.1128/mBio.02566-18

    Butyrate: microbial production, fuel use, signaling and nutrient interactions (2026-09-19) · lines 78–84

    AI-assisted research curation; primary-abstract references and experimental limitations individually identified. Not publisher full text. · supports · Healthy young adults; four dietary interventions. · source_derived_draft · unverified_draft

    ## butyrate-resistant-starch-human Fiber type and the starting microbial community changed the response. In the 174-person two-week fiber study, resistant potato starch produced the greatest fecal SCFA/butyrate rise; resistant maize starch and inulin did not significantly increase fecal butyrate. Model: Healthy young adults; four dietary interventions. Limitations: Fecal concentration is not a direct measure of total production or absorbed dose. Evidence access: Primary abstract Dynamics of Human Gut Microbiota and Short-Chain Fatty Acids in Response to Dietary Interventions with Three Fermentable Fibers. · 2019 · https://pubmed.ncbi.nlm.nih.gov/30696735/ · DOI 10.1128/mBio.02566-18
    Complete structured claim and evidence

  2. Combining the 50 and 100 mg/day riboflavin arms in RIBOGUT showed increased fecal butyrate after two weeks; separate-dose analyses showed only minor SCFA differences.

    Riboflavin (vitamin B2) → Human fecal butyrate concentration source_derived_draftungraded
    Experimental context and source evidence
    evidence_access
    Primary full text, results and Figure 6
    experimental_model
    Randomized placebo-controlled human study; pooled dose analysis.
    limitations
    Fecal concentration was measured, not production flux. Neither dose increased F. prausnitzii abundance; this does not establish a universal B2 deficiency gate.
    nutrient_topic
    Butyrate collection; molecular form, preparation, species, exposure and manipulation remain explicit. · Butyrate
    plain_language
    A vitamin B2 trial found a butyrate signal after pooling doses.
    primary_references
    Riboflavin Supplementation Promotes Butyrate Production in the Absence of Gross Compositional Changes in the Gut Microbiota. · 2023 · https://pubmed.ncbi.nlm.nih.gov/35943883/ · DOI 10.1089/ars.2022.0033

    Butyrate: microbial production, fuel use, signaling and nutrient interactions (2026-09-19) · lines 86–92

    AI-assisted research curation; primary-abstract references and experimental limitations individually identified. Not publisher full text. · supports · Randomized placebo-controlled human study; pooled dose analysis. · source_derived_draft · unverified_draft

    ## butyrate-riboflavin-pooled A vitamin B2 trial found a butyrate signal after pooling doses. Combining the 50 and 100 mg/day riboflavin arms in RIBOGUT showed increased fecal butyrate after two weeks; separate-dose analyses showed only minor SCFA differences. Model: Randomized placebo-controlled human study; pooled dose analysis. Limitations: Fecal concentration was measured, not production flux. Neither dose increased F. prausnitzii abundance; this does not establish a universal B2 deficiency gate. Evidence access: Primary full text, results and Figure 6 Riboflavin Supplementation Promotes Butyrate Production in the Absence of Gross Compositional Changes in the Gut Microbiota. · 2023 · https://pubmed.ncbi.nlm.nih.gov/35943883/ · DOI 10.1089/ars.2022.0033
    Complete structured claim and evidence

Where it participates (unsigned role)

  1. Oral butyrate increased plasma butyrate without increasing fecal butyrate in the hypertension trial.

    Butyrate → Human circulating butyrate concentration source_derived_draftungraded
    Experimental context and source evidence
    availability_state
    biomarker_context Imported condition classification; unverified.
    evidence_access
    Primary abstract
    experimental_model
    Same randomized human oral trial.
    limitations
    Neither compartment is a universal measure of intracellular sufficiency or total microbial production.
    nutrient_topic
    Butyrate collection; molecular form, preparation, species, exposure and manipulation remain explicit. · Butyrate
    plain_language
    Blood and stool measurements did not change together.
    primary_references
    Effects of Oral Butyrate on Blood Pressure in Patients With Hypertension: A Randomized, Placebo-Controlled Trial. · 2024 · https://pubmed.ncbi.nlm.nih.gov/39034917/ · DOI 10.1161/HYPERTENSIONAHA.123.22437
    trigger_kind
    biomarker_context Imported condition classification; unverified.

    Butyrate: microbial production, fuel use, signaling and nutrient interactions (2026-09-19) · lines 598–604

    AI-assisted research curation; primary-abstract references and experimental limitations individually identified. Not publisher full text. · supports · Same randomized human oral trial. · source_derived_draft · unverified_draft

    ## butyrate-plasma-feces-diverge Blood and stool measurements did not change together. Oral butyrate increased plasma butyrate without increasing fecal butyrate in the hypertension trial. Model: Same randomized human oral trial. Limitations: Neither compartment is a universal measure of intracellular sufficiency or total microbial production. Evidence access: Primary abstract Effects of Oral Butyrate on Blood Pressure in Patients With Hypertension: A Randomized, Placebo-Controlled Trial. · 2024 · https://pubmed.ncbi.nlm.nih.gov/39034917/ · DOI 10.1161/HYPERTENSIONAHA.123.22437
    Complete structured claim and evidence

In the sources

Preserved passages that mention this component, quoted exactly. Open one to read it in context.

    This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.

    Evidence, AI assistance and curation standards