{"id":"093841b5-2dd0-5485-8f37-62ae8bf9425f","stable_key":"104835a3-b891-5dc4-a6bb-42ab7c6f96c4:butyrate-plasma-feces-diverge","predicate":"modulates","statement":"Oral butyrate increased plasma butyrate without increasing fecal butyrate in the hypertension trial.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"c04fb177-d0c2-5137-bc68-e3e91f20e5a3","mechanism_event_label":"Blood and stool measurements did not change together.","subject":{"id":"e7428a7f-d35a-5406-9904-a88984814833","slug":"butyrate","display_name":"Butyrate","entity_type_key":"small_molecule"},"object":{"id":"1297f075-36ff-59fe-86d9-369f74c3885d","slug":"human-plasma-butyrate","display_name":"Human circulating butyrate concentration","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"c04fb177-d0c2-5137-bc68-e3e91f20e5a3","stable_key":"104835a3-b891-5dc4-a6bb-42ab7c6f96c4:butyrate-plasma-feces-diverge-event","event_type":"observed_relationship","label":"Blood and stool measurements did not change together.","description":"Oral butyrate increased plasma butyrate without increasing fecal butyrate in the hypertension trial.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"e7428a7f-d35a-5406-9904-a88984814833","slug":"butyrate","display_name":"Butyrate","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"1297f075-36ff-59fe-86d9-369f74c3885d","slug":"human-plasma-butyrate","display_name":"Human circulating butyrate concentration","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"779c12eb-a540-5331-81b2-6d9c1c8a3751","slug":"human-fecal-butyrate","display_name":"Human fecal butyrate concentration","entity_type_key":"cellular_process"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""},{"entity":{"id":"4baf6011-dcc4-5a69-9c77-a21de6060383","slug":"sodium-butyrate","display_name":"Sodium butyrate","entity_type_key":"chemical_species"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":3,"notes":""}]},"contexts":[{"dimension":"availability_state","value_text":"biomarker_context","comparator":null,"unit":null,"notes":"Imported condition classification; 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