{"id":"65572364-bcbe-55f4-8490-3693d26e8e30","stable_key":"104835a3-b891-5dc4-a6bb-42ab7c6f96c4:butyrate-resistant-starch-human","predicate":"increases","statement":"In the 174-person two-week fiber study, resistant potato starch produced the greatest fecal SCFA/butyrate rise; resistant maize starch and inulin did not significantly increase fecal butyrate.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"023042b5-904e-52bc-8b05-097e2162d5db","mechanism_event_label":"Fiber type and the starting microbial community changed the response.","subject":{"id":"45dc7e38-1dd6-5f89-844e-d3cda41ca74c","slug":"resistant-potato-starch","display_name":"Resistant potato starch preparation","entity_type_key":"chemical_species"},"object":{"id":"779c12eb-a540-5331-81b2-6d9c1c8a3751","slug":"human-fecal-butyrate","display_name":"Human fecal butyrate concentration","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"023042b5-904e-52bc-8b05-097e2162d5db","stable_key":"104835a3-b891-5dc4-a6bb-42ab7c6f96c4:butyrate-resistant-starch-human-event","event_type":"observed_relationship","label":"Fiber type and the starting microbial community changed the response.","description":"In the 174-person two-week fiber study, resistant potato starch produced the greatest fecal SCFA/butyrate rise; resistant maize starch and inulin did not significantly increase fecal butyrate.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"45dc7e38-1dd6-5f89-844e-d3cda41ca74c","slug":"resistant-potato-starch","display_name":"Resistant potato starch preparation","entity_type_key":"chemical_species"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"779c12eb-a540-5331-81b2-6d9c1c8a3751","slug":"human-fecal-butyrate","display_name":"Human fecal butyrate concentration","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"e7428a7f-d35a-5406-9904-a88984814833","slug":"butyrate","display_name":"Butyrate","entity_type_key":"small_molecule"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""}]},"contexts":[{"dimension":"evidence_access","value_text":"Primary abstract","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Healthy young adults; four dietary interventions.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Fecal concentration is not a direct measure of total production or absorbed dose.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Butyrate collection; molecular form, preparation, species, exposure and manipulation remain explicit.","comparator":null,"unit":null,"notes":"","entity":{"slug":"butyrate","display_name":"Butyrate","entity_type_key":"small_molecule"}},{"dimension":"plain_language","value_text":"Fiber type and the starting microbial community changed the response.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"Dynamics of Human Gut Microbiota and Short-Chain Fatty Acids in Response to Dietary Interventions with Three Fermentable Fibers. · 2019 · https://pubmed.ncbi.nlm.nih.gov/30696735/ · DOI 10.1128/mBio.02566-18","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"68095eab-c735-56f7-a1e5-a83d40a55564","evidence_kind":"source_excerpt","locator":"Lines 78-84","start_line":78,"end_line":84,"excerpt":"## butyrate-resistant-starch-human\nFiber type and the starting microbial community changed the response.\nIn the 174-person two-week fiber study, resistant potato starch produced the greatest fecal SCFA/butyrate rise; resistant maize starch and inulin did not significantly increase fecal butyrate.\nModel: Healthy young adults; four dietary interventions.\nLimitations: Fecal concentration is not a direct measure of total production or absorbed dose.\nEvidence access: Primary abstract\nDynamics of Human Gut Microbiota and Short-Chain Fatty Acids in Response to Dietary Interventions with Three Fermentable Fibers. · 2019 · https://pubmed.ncbi.nlm.nih.gov/30696735/ · DOI 10.1128/mBio.02566-18","model_system":"Healthy young adults; four dietary interventions.","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Original curation paraphrase; evidence access and experimental limitations specified.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"33205bb8-dcbe-5d2c-afca-86075d7748d1","stable_key":"import-104835a3-b891-5dc4-a6bb-42ab7c6f96c4","title":"Butyrate: microbial production, fuel use, signaling and nutrient interactions (2026-09-19)","document_type":"imported_text","citation_label":"AI-assisted research curation; primary-abstract references and experimental limitations individually identified. Not publisher full text.","file_path":"","sha256":"a1253eb4426fc45d7b7c113028aa4ba2e9f89a9653272f3795437fc222bad558","revision_id":"c2320e65-a252-57a9-8838-7abf3d23400e","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}