Component
Human circulating luteinizing hormone
Context-specific entity; species, compartment and exposure are stated on each claim.
2 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
What acts on it
After 12 days, 23 men taking 3.12 g/day sodium D-aspartate with B6, folate and B12 had a reported 33% mean LH rise from baseline; 20 men received sodium-chloride placebo with the same vitamins.
Experimental context and source evidence
- evidence_access
- Primary full text
- experimental_model
- Men aged 27-37; morning serum sampling; DADAVIT formulation.
- limitations
- Randomization was not clearly described in the accessed methods. Sodium-salt mass is not free-acid mass; no evidence of vitamin synergy from this design.
- nutrient_topic
- D-Aspartate collection; species, compartment, exposure, co-substrates and manipulation remain explicit. · D-Aspartate
- plain_language
- A small early study reported a hormone change with a matched-vitamin comparison.
- primary_references
- The role and molecular mechanism of D-aspartic acid in the release and synthesis of LH and testosterone in humans and rats. · 2009 · https://pubmed.ncbi.nlm.nih.gov/19860889/ · DOI 10.1186/1477-7827-7-120
D-Aspartate: synthesis, clearance, neural and endocrine mechanisms (2026-09-19) · lines 320–326
AI-assisted research curation; primary references, access levels and experimental limitations individually identified. Not publisher full text. · supports · Men aged 27-37; morning serum sampling; DADAVIT formulation. · source_derived_draft · unverified_draft
## d-aspartate-human-early-lh A small early study reported a hormone change with a matched-vitamin comparison. After 12 days, 23 men taking 3.12 g/day sodium D-aspartate with B6, folate and B12 had a reported 33% mean LH rise from baseline; 20 men received sodium-chloride placebo with the same vitamins. Model: Men aged 27-37; morning serum sampling; DADAVIT formulation. Limitations: Randomization was not clearly described in the accessed methods. Sodium-salt mass is not free-acid mass; no evidence of vitamin synergy from this design. Evidence access: Primary full text The role and molecular mechanism of D-aspartic acid in the release and synthesis of LH and testosterone in humans and rats. · 2009 · https://pubmed.ncbi.nlm.nih.gov/19860889/ · DOI 10.1186/1477-7827-7-120
Complete structured claim and evidence
Where it participates (unsigned role)
The same 12-day sodium D-aspartate study reported mean testosterone rising from 4.5 to 6.4 ng/mL; the matched-vitamin placebo group showed no corresponding increase.
Experimental context and source evidence
- evidence_access
- Primary full text
- experimental_model
- 23 treated and 20 placebo men; 3.12 g/day sodium D-aspartate, B6/folate/B12 in both arms.
- limitations
- Not a general testosterone-boosting effect; same cohort as the LH claim, not independent evidence.
- nutrient_topic
- D-Aspartate collection; species, compartment, exposure, co-substrates and manipulation remain explicit. · D-Aspartate
- plain_language
- The early testosterone result belongs to this specific short study.
- primary_references
- The role and molecular mechanism of D-aspartic acid in the release and synthesis of LH and testosterone in humans and rats. · 2009 · https://pubmed.ncbi.nlm.nih.gov/19860889/ · DOI 10.1186/1477-7827-7-120
D-Aspartate: synthesis, clearance, neural and endocrine mechanisms (2026-09-19) · lines 328–334
AI-assisted research curation; primary references, access levels and experimental limitations individually identified. Not publisher full text. · supports · 23 treated and 20 placebo men; 3.12 g/day sodium D-aspartate, B6/folate/B12 in both arms. · source_derived_draft · unverified_draft
## d-aspartate-human-early-testosterone The early testosterone result belongs to this specific short study. The same 12-day sodium D-aspartate study reported mean testosterone rising from 4.5 to 6.4 ng/mL; the matched-vitamin placebo group showed no corresponding increase. Model: 23 treated and 20 placebo men; 3.12 g/day sodium D-aspartate, B6/folate/B12 in both arms. Limitations: Not a general testosterone-boosting effect; same cohort as the LH claim, not independent evidence. Evidence access: Primary full text The role and molecular mechanism of D-aspartic acid in the release and synthesis of LH and testosterone in humans and rats. · 2009 · https://pubmed.ncbi.nlm.nih.gov/19860889/ · DOI 10.1186/1477-7827-7-120
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.