{"id":"93d2af3a-c53b-5e73-9ce6-5ad327f9f305","stable_key":"9a47f338-d127-5e4d-abf6-e99056833a69:d-aspartate-human-early-testosterone","predicate":"increases_tested","statement":"The same 12-day sodium D-aspartate study reported mean testosterone rising from 4.5 to 6.4 ng/mL; the matched-vitamin placebo group showed no corresponding increase.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"1e3137a2-780d-5886-a6d5-3faafbd041f1","mechanism_event_label":"The early testosterone result belongs to this specific short study.","subject":{"id":"b3404670-6db1-517f-b9a0-27ecfaac558b","slug":"d-aspartate","display_name":"D-Aspartate","entity_type_key":"small_molecule"},"object":{"id":"dffa79cf-8fea-51e0-8839-6ca30a81cd6a","slug":"circulating-total-testosterone","display_name":"Circulating total testosterone concentration","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"1e3137a2-780d-5886-a6d5-3faafbd041f1","stable_key":"9a47f338-d127-5e4d-abf6-e99056833a69:d-aspartate-human-early-testosterone-event","event_type":"observed_relationship","label":"The early testosterone result belongs to this specific short study.","description":"The same 12-day sodium D-aspartate study reported mean testosterone rising from 4.5 to 6.4 ng/mL; the matched-vitamin placebo group showed no corresponding increase.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"b3404670-6db1-517f-b9a0-27ecfaac558b","slug":"d-aspartate","display_name":"D-Aspartate","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"dffa79cf-8fea-51e0-8839-6ca30a81cd6a","slug":"circulating-total-testosterone","display_name":"Circulating total testosterone concentration","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"e3013e06-20da-5c91-b8f8-d9364a645fae","slug":"testosterone","display_name":"Testosterone","entity_type_key":"small_molecule"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""},{"entity":{"id":"645f0a63-d9e5-51f1-a8c4-f885e4ac07af","slug":"human-circulating-lh","display_name":"Human circulating luteinizing hormone","entity_type_key":"cellular_process"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":3,"notes":""}]},"contexts":[{"dimension":"evidence_access","value_text":"Primary full text","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"23 treated and 20 placebo men; 3.12 g/day sodium D-aspartate, B6/folate/B12 in both arms.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Not a general testosterone-boosting effect; same cohort as the LH claim, not independent evidence.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"D-Aspartate collection; species, compartment, exposure, co-substrates and manipulation remain explicit.","comparator":null,"unit":null,"notes":"","entity":{"slug":"d-aspartate","display_name":"D-Aspartate","entity_type_key":"small_molecule"}},{"dimension":"plain_language","value_text":"The early testosterone result belongs to this specific short study.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"The role and molecular mechanism of D-aspartic acid in the release and synthesis of LH and testosterone in humans and rats. · 2009 · https://pubmed.ncbi.nlm.nih.gov/19860889/ · DOI 10.1186/1477-7827-7-120","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"5c6407b8-76c6-5078-aea3-2d163a406a9b","evidence_kind":"source_excerpt","locator":"Lines 328-334","start_line":328,"end_line":334,"excerpt":"## d-aspartate-human-early-testosterone\nThe early testosterone result belongs to this specific short study.\nThe same 12-day sodium D-aspartate study reported mean testosterone rising from 4.5 to 6.4 ng/mL; the matched-vitamin placebo group showed no corresponding increase.\nModel: 23 treated and 20 placebo men; 3.12 g/day sodium D-aspartate, B6/folate/B12 in both arms.\nLimitations: Not a general testosterone-boosting effect; same cohort as the LH claim, not independent evidence.\nEvidence access: Primary full text\nThe role and molecular mechanism of D-aspartic acid in the release and synthesis of LH and testosterone in humans and rats. · 2009 · https://pubmed.ncbi.nlm.nih.gov/19860889/ · DOI 10.1186/1477-7827-7-120","model_system":"23 treated and 20 placebo men; 3.12 g/day sodium D-aspartate, B6/folate/B12 in both arms.","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Original curation paraphrase; evidence access and experimental limitations specified.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"3751103e-e256-5615-b24f-39cc76ccfb47","stable_key":"import-9a47f338-d127-5e4d-abf6-e99056833a69","title":"D-Aspartate: synthesis, clearance, neural and endocrine mechanisms (2026-09-19)","document_type":"imported_text","citation_label":"AI-assisted research curation; primary references, access levels and experimental limitations individually identified. Not publisher full text.","file_path":"","sha256":"0a86a1008edb8a69dcc79409e76e3fd5ce59b0747be8cae8f21e43f871e76248","revision_id":"a1de4b66-263d-5452-8ed8-df853afba030","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}