{"id":"0d31a32c-83d8-59eb-bd91-5a2cc5e7134e","stable_key":"9a47f338-d127-5e4d-abf6-e99056833a69:d-aspartate-human-early-lh","predicate":"increases_tested","statement":"After 12 days, 23 men taking 3.12 g/day sodium D-aspartate with B6, folate and B12 had a reported 33% mean LH rise from baseline; 20 men received sodium-chloride placebo with the same vitamins.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"b5326786-db0f-51d0-b38f-a9a0f2da0749","mechanism_event_label":"A small early study reported a hormone change with a matched-vitamin comparison.","subject":{"id":"b3404670-6db1-517f-b9a0-27ecfaac558b","slug":"d-aspartate","display_name":"D-Aspartate","entity_type_key":"small_molecule"},"object":{"id":"645f0a63-d9e5-51f1-a8c4-f885e4ac07af","slug":"human-circulating-lh","display_name":"Human circulating luteinizing hormone","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"b5326786-db0f-51d0-b38f-a9a0f2da0749","stable_key":"9a47f338-d127-5e4d-abf6-e99056833a69:d-aspartate-human-early-lh-event","event_type":"observed_relationship","label":"A small early study reported a hormone change with a matched-vitamin comparison.","description":"After 12 days, 23 men taking 3.12 g/day sodium D-aspartate with B6, folate and B12 had a reported 33% mean LH rise from baseline; 20 men received sodium-chloride placebo with the same vitamins.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"b3404670-6db1-517f-b9a0-27ecfaac558b","slug":"d-aspartate","display_name":"D-Aspartate","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"645f0a63-d9e5-51f1-a8c4-f885e4ac07af","slug":"human-circulating-lh","display_name":"Human circulating luteinizing hormone","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""}]},"contexts":[{"dimension":"evidence_access","value_text":"Primary full text","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Men aged 27-37; morning serum sampling; DADAVIT formulation.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Randomization was not clearly described in the accessed methods. Sodium-salt mass is not free-acid mass; no evidence of vitamin synergy from this design.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"D-Aspartate collection; species, compartment, exposure, co-substrates and manipulation remain explicit.","comparator":null,"unit":null,"notes":"","entity":{"slug":"d-aspartate","display_name":"D-Aspartate","entity_type_key":"small_molecule"}},{"dimension":"plain_language","value_text":"A small early study reported a hormone change with a matched-vitamin comparison.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"The role and molecular mechanism of D-aspartic acid in the release and synthesis of LH and testosterone in humans and rats. · 2009 · https://pubmed.ncbi.nlm.nih.gov/19860889/ · DOI 10.1186/1477-7827-7-120","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"993f2256-5906-531c-af10-eb9f9cf00950","evidence_kind":"source_excerpt","locator":"Lines 320-326","start_line":320,"end_line":326,"excerpt":"## d-aspartate-human-early-lh\nA small early study reported a hormone change with a matched-vitamin comparison.\nAfter 12 days, 23 men taking 3.12 g/day sodium D-aspartate with B6, folate and B12 had a reported 33% mean LH rise from baseline; 20 men received sodium-chloride placebo with the same vitamins.\nModel: Men aged 27-37; morning serum sampling; DADAVIT formulation.\nLimitations: Randomization was not clearly described in the accessed methods. Sodium-salt mass is not free-acid mass; no evidence of vitamin synergy from this design.\nEvidence access: Primary full text\nThe role and molecular mechanism of D-aspartic acid in the release and synthesis of LH and testosterone in humans and rats. · 2009 · https://pubmed.ncbi.nlm.nih.gov/19860889/ · DOI 10.1186/1477-7827-7-120","model_system":"Men aged 27-37; morning serum sampling; DADAVIT formulation.","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Original curation paraphrase; evidence access and experimental limitations specified.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"3751103e-e256-5615-b24f-39cc76ccfb47","stable_key":"import-9a47f338-d127-5e4d-abf6-e99056833a69","title":"D-Aspartate: synthesis, clearance, neural and endocrine mechanisms (2026-09-19)","document_type":"imported_text","citation_label":"AI-assisted research curation; primary references, access levels and experimental limitations individually identified. Not publisher full text.","file_path":"","sha256":"0a86a1008edb8a69dcc79409e76e3fd5ce59b0747be8cae8f21e43f871e76248","revision_id":"a1de4b66-263d-5452-8ed8-df853afba030","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}