Component

Human CAMP mRNA

Study-defined Human CAMP mRNA. Read each linked record for species, exposure and endpoint.

4 recorded relationships. Experimental role, claim status and evidence remain attached to each record.

Read recorded mechanisms Open recursive mind map

How nutrients influence it

Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.

How nutrients reach it in more than one step

Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.

Tracing routes…

What it does

Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.

Recorded relationships

What acts on it

  1. Serum collected after D2 treatment of low-status patients better supported TLR-triggered monocyte hCAP expression ex vivo.

    Ergocalciferol / vitamin D2 → Human CAMP mRNA source_derived_draftungraded
    Experimental context and source evidence
    cross_nutrient
    false
    experimental_model
    Human bone-clinic cohort and ex-vivo monocytes in 10% autologous serum
    exposure
    D2 50, 000 IU twice weekly 5 weeks in low-status patients; paired serum used for ex-vivo assays.
    limitations
    Before/after serum comparison; no randomized D2/D3 head-to-head or demonstrated reduction of infections.
    nutrient_topic
    Vitamin D2 and D3 research collection; topical membership is not evidence of a direct dietary effect. · Vitamin D2 and D3
    organism
    Homo sapiens
    plain_language
    D2 treatment changed serum support for a local cell response.
    primary_references
    [adams2009] Vitamin d-directed rheostatic regulation of monocyte antibacterial responses. (2009). https://pubmed.ncbi.nlm.nih.gov/19299728/ DOI: 10.4049/jimmunol.0803736
    tissue_or_cell_type
    Patient serum and ex-vivo monocytes

    Vitamin D2 and D3: mechanisms, deficiency and nutrient interactions (2026-09-17) · lines 1009–1020

    AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Human bone-clinic cohort and ex-vivo monocytes in 10% autologous serum · source_derived_draft · unverified_draft

    ### vd-adams-d2-serum-rescue Serum collected after D2 treatment of low-status patients better supported TLR-triggered monocyte hCAP expression ex vivo. Condition category: normal nutrient_topic: Vitamin D2 and D3 research collection; topical membership is not evidence of a direct dietary effect. plain_language: D2 treatment changed serum support for a local cell response. organism: Homo sapiens tissue_or_cell_type: Patient serum and ex-vivo monocytes experimental_model: Human bone-clinic cohort and ex-vivo monocytes in 10% autologous serum limitations: Before/after serum comparison; no randomized D2/D3 head-to-head or demonstrated reduction of infections. exposure: D2 50, 000 IU twice weekly 5 weeks in low-status patients; paired serum used for ex-vivo assays. cross_nutrient: false [adams2009] Vitamin d-directed rheostatic regulation of monocyte antibacterial responses. (2009). https://pubmed.ncbi.nlm.nih.gov/19299728/ DOI: 10.4049/jimmunol.0803736
    Complete structured claim and evidence

  2. In monocytes cultured with 10% autologous serum, 19 kDa TLR2/1 agonist increased CYP27B1 yet reduced hCAP transcript; expression was enhanced by adding 5 nM 25(OH)D3.

    Mycobacterial 19 kDa lipopeptide TLR agonist → Human CAMP mRNA source_derived_draftungraded
    Experimental context and source evidence
    availability_state
    nutrient_deficiency Imported condition classification; unverified.
    cross_nutrient
    false
    experimental_model
    Human bone-clinic cohort and ex-vivo monocytes in 10% autologous serum
    exposure
    24-hour ex-vivo culture; 10% autologous serum, with or without added 5 nM 25(OH)D3.
    limitations
    Ex-vivo monocytes in 10% serum, not a whole-person infection endpoint. Low-substrate medium is not a validated universal blood threshold.
    nutrient_topic
    Vitamin D2 and D3 research collection; topical membership is not evidence of a direct dietary effect. · Vitamin D2 and D3
    organism
    Homo sapiens
    plain_language
    Making more activation machinery did not guarantee an antimicrobial response when substrate supply was limited.
    primary_references
    [adams2009] Vitamin d-directed rheostatic regulation of monocyte antibacterial responses. (2009). https://pubmed.ncbi.nlm.nih.gov/19299728/ DOI: 10.4049/jimmunol.0803736
    tissue_or_cell_type
    Human monocytes
    trigger_kind
    nutrient_deficiency Imported condition classification; unverified.

    Vitamin D2 and D3: mechanisms, deficiency and nutrient interactions (2026-09-17) · lines 983–994

    AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Human bone-clinic cohort and ex-vivo monocytes in 10% autologous serum · source_derived_draft · unverified_draft

    ### vd-adams-low-substrate In monocytes cultured with 10% autologous serum, 19 kDa TLR2/1 agonist increased CYP27B1 yet reduced hCAP transcript; expression was enhanced by adding 5 nM 25(OH)D3. Condition category: nutrient_deficiency nutrient_topic: Vitamin D2 and D3 research collection; topical membership is not evidence of a direct dietary effect. plain_language: Making more activation machinery did not guarantee an antimicrobial response when substrate supply was limited. organism: Homo sapiens tissue_or_cell_type: Human monocytes experimental_model: Human bone-clinic cohort and ex-vivo monocytes in 10% autologous serum limitations: Ex-vivo monocytes in 10% serum, not a whole-person infection endpoint. Low-substrate medium is not a validated universal blood threshold. exposure: 24-hour ex-vivo culture; 10% autologous serum, with or without added 5 nM 25(OH)D3. cross_nutrient: false [adams2009] Vitamin d-directed rheostatic regulation of monocyte antibacterial responses. (2009). https://pubmed.ncbi.nlm.nih.gov/19299728/ DOI: 10.4049/jimmunol.0803736
    Complete structured claim and evidence

  3. Calcitriol induced CAMP expression in tested human myeloid, keratinocyte and colon cell models and bone-marrow-derived cells.

    Calcitriol → Human CAMP mRNA source_derived_draftungraded
    Experimental context and source evidence
    cross_nutrient
    false
    experimental_model
    Human cell lines and bone-marrow-derived cells; promoter studies and mouse comparison
    exposure
    Calcitriol-treated primary cells and cell lines; concentrations not recovered from the abstract.
    limitations
    Human cell and promoter experiments; no oral D2/D3 efficacy or infection-incidence trial.
    nutrient_topic
    Vitamin D2 and D3 research collection; topical membership is not evidence of a direct dietary effect. · Vitamin D2 and D3
    organism
    Homo sapiens
    plain_language
    The active D3 hormone increased the instructions for an antimicrobial protein.
    primary_references
    [gombart2005] Human cathelicidin antimicrobial peptide (CAMP) gene is a direct target of the vitamin D receptor and is strongly up-regulated in myeloid cells by 1,25-dihydroxyvitamin D3. (2005). https://pubmed.ncbi.nlm.nih.gov/15985530/ DOI: 10.1096/fj.04-3284com
    tissue_or_cell_type
    Human myeloid and epithelial cells

    Vitamin D2 and D3: mechanisms, deficiency and nutrient interactions (2026-09-17) · lines 905–916

    AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Human cell lines and bone-marrow-derived cells; promoter studies and mouse comparison · source_derived_draft · unverified_draft

    ### vd-camp-transcription Calcitriol induced CAMP expression in tested human myeloid, keratinocyte and colon cell models and bone-marrow-derived cells. Condition category: normal nutrient_topic: Vitamin D2 and D3 research collection; topical membership is not evidence of a direct dietary effect. plain_language: The active D3 hormone increased the instructions for an antimicrobial protein. organism: Homo sapiens tissue_or_cell_type: Human myeloid and epithelial cells experimental_model: Human cell lines and bone-marrow-derived cells; promoter studies and mouse comparison limitations: Human cell and promoter experiments; no oral D2/D3 efficacy or infection-incidence trial. exposure: Calcitriol-treated primary cells and cell lines; concentrations not recovered from the abstract. cross_nutrient: false [gombart2005] Human cathelicidin antimicrobial peptide (CAMP) gene is a direct target of the vitamin D receptor and is strongly up-regulated in myeloid cells by 1,25-dihydroxyvitamin D3. (2005). https://pubmed.ncbi.nlm.nih.gov/15985530/ DOI: 10.1096/fj.04-3284com
    Complete structured claim and evidence

  4. Adding 25(OH)D3 to low-vitamin-D serum restored IFN-gamma -induced antimicrobial peptide expression.

    Calcifediol / 25-hydroxyvitamin D3 → Human CAMP mRNA source_derived_draftungraded
    Experimental context and source evidence
    availability_state
    nutrient_deficiency Imported condition classification; unverified.
    cross_nutrient
    false
    experimental_model
    Human macrophage IFN-gamma experiments with sera of differing 25OHD content
    exposure
    IFN-gamma -stimulated human macrophages; low-vitamin-D serum with 25(OH)D3 add-back; dose/time not recovered from abstract.
    limitations
    Cultured human macrophages and selected serum pools; no universal serum threshold or clinical tuberculosis cure inferred.
    nutrient_topic
    Vitamin D2 and D3 research collection; topical membership is not evidence of a direct dietary effect. · Vitamin D2 and D3
    organism
    Homo sapiens
    plain_language
    Adding precursor restored the antimicrobial gene response.
    primary_references
    [fabri2011] Vitamin D is required for IFN-gamma-mediated antimicrobial activity of human macrophages. (2011). https://pubmed.ncbi.nlm.nih.gov/21998409/ DOI: 10.1126/scitranslmed.3003045
    tissue_or_cell_type
    Human macrophages
    trigger_kind
    nutrient_deficiency Imported condition classification; unverified.

    Vitamin D2 and D3: mechanisms, deficiency and nutrient interactions (2026-09-17) · lines 1035–1046

    AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Human macrophage IFN-gamma experiments with sera of differing 25OHD content · source_derived_draft · unverified_draft

    ### vd-fabri-camp Adding 25(OH)D3 to low-vitamin-D serum restored IFN-gamma -induced antimicrobial peptide expression. Condition category: nutrient_deficiency nutrient_topic: Vitamin D2 and D3 research collection; topical membership is not evidence of a direct dietary effect. plain_language: Adding precursor restored the antimicrobial gene response. organism: Homo sapiens tissue_or_cell_type: Human macrophages experimental_model: Human macrophage IFN-gamma experiments with sera of differing 25OHD content limitations: Cultured human macrophages and selected serum pools; no universal serum threshold or clinical tuberculosis cure inferred. exposure: IFN-gamma -stimulated human macrophages; low-vitamin-D serum with 25(OH)D3 add-back; dose/time not recovered from abstract. cross_nutrient: false [fabri2011] Vitamin D is required for IFN-gamma-mediated antimicrobial activity of human macrophages. (2011). https://pubmed.ncbi.nlm.nih.gov/21998409/ DOI: 10.1126/scitranslmed.3003045
    Complete structured claim and evidence

In the sources

Preserved passages that mention this component, quoted exactly. Open one to read it in context.

    This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.

    Evidence, AI assistance and curation standards