Component

Human blood ergothioneine concentration, compartment specified

Context-specific entity; species, compartment and exposure are stated on each claim.

4 recorded relationships. Experimental role, claim status and evidence remain attached to each record.

Read recorded mechanisms Open recursive mind map

How nutrients influence it

Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.

How nutrients reach it in more than one step

Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.

Tracing routes…

What it does

Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.

Recorded relationships

What it acts on

  1. In 3236 initially CVD- and diabetes-free participants, higher baseline ergothioneine predicted lower coronary disease and mortality over a median 21.4 years.

    Human blood ergothioneine concentration, compartment specified → Human cardiovascular/mortality association with baseline ergothioneine source_derived_draftungraded
    Experimental context and source evidence
    availability_state
    biomarker_context Imported condition classification; unverified.
    evidence_access
    Primary abstract
    experimental_model
    Malmo Diet and Cancer observational cohort; adjusted associations.
    limitations
    Healthy dietary pattern and other confounding prevent a causal supplement conclusion.
    nutrient_topic
    Ergothioneine collection; molecular form, preparation, species, exposure and manipulation remain explicit. · L-Ergothioneine
    plain_language
    A higher blood marker tracked better long-term outcomes.
    primary_references
    Ergothioneine is associated with reduced mortality and decreased risk of cardiovascular disease. · 2020 · https://pubmed.ncbi.nlm.nih.gov/31672783/ · DOI 10.1136/heartjnl-2019-315485
    trigger_kind
    biomarker_context Imported condition classification; unverified.

    Ergothioneine: transport, redox chemistry and cross-nutrient mechanisms (2026-09-19) · lines 488–494

    AI-assisted research curation; primary references, access levels and experimental limitations individually identified. Not publisher full text. · supports · Malmo Diet and Cancer observational cohort; adjusted associations. · source_derived_draft · unverified_draft

    ## ergothioneine-cv-observational A higher blood marker tracked better long-term outcomes. In 3236 initially CVD- and diabetes-free participants, higher baseline ergothioneine predicted lower coronary disease and mortality over a median 21.4 years. Model: Malmo Diet and Cancer observational cohort; adjusted associations. Limitations: Healthy dietary pattern and other confounding prevent a causal supplement conclusion. Evidence access: Primary abstract Ergothioneine is associated with reduced mortality and decreased risk of cardiovascular disease. · 2020 · https://pubmed.ncbi.nlm.nih.gov/31672783/ · DOI 10.1136/heartjnl-2019-315485
    Complete structured claim and evidence

  2. Human whole-blood ergothioneine correlated with hercynine and S-methyl-ergothioneine, consistent with possible metabolism.

    Human blood ergothioneine concentration, compartment specified → S-Methyl-ergothioneine source_derived_draftungraded
    Experimental context and source evidence
    availability_state
    biomarker_context Imported condition classification; unverified.
    evidence_access
    Primary abstract
    experimental_model
    Human oral-administration study.
    limitations
    Correlation does not identify the human enzymes or prove every conversion direction.
    nutrient_topic
    Ergothioneine collection; molecular form, preparation, species, exposure and manipulation remain explicit. · L-Ergothioneine
    plain_language
    Related molecules may help trace its fate.
    primary_references
    Administration of Pure Ergothioneine to Healthy Human Subjects: Uptake, Metabolism, and Effects on Biomarkers of Oxidative Damage and Inflammation. · 2017 · https://pubmed.ncbi.nlm.nih.gov/27488221/ · DOI 10.1089/ars.2016.6778
    trigger_kind
    biomarker_context Imported condition classification; unverified.

    Ergothioneine: transport, redox chemistry and cross-nutrient mechanisms (2026-09-19) · lines 472–478

    AI-assisted research curation; primary references, access levels and experimental limitations individually identified. Not publisher full text. · supports · Human oral-administration study. · source_derived_draft · unverified_draft

    ## ergothioneine-human-metabolite-markers Related molecules may help trace its fate. Human whole-blood ergothioneine correlated with hercynine and S-methyl-ergothioneine, consistent with possible metabolism. Model: Human oral-administration study. Limitations: Correlation does not identify the human enzymes or prove every conversion direction. Evidence access: Primary abstract Administration of Pure Ergothioneine to Healthy Human Subjects: Uptake, Metabolism, and Effects on Biomarkers of Oxidative Damage and Inflammation. · 2017 · https://pubmed.ncbi.nlm.nih.gov/27488221/ · DOI 10.1089/ars.2016.6778
    Complete structured claim and evidence

What acts on it

  1. Oral pure ergothioneine increased plasma and whole-blood concentrations in healthy volunteers, with urinary recovery below 4% of the administered amount.

    L-Ergothioneine → Human blood ergothioneine concentration, compartment specified source_derived_draftungraded
    Experimental context and source evidence
    evidence_access
    Primary abstract
    experimental_model
    Human oral uptake/pharmacokinetic study.
    limitations
    Blood measurements do not establish tissue-specific sufficiency.
    nutrient_topic
    Ergothioneine collection; molecular form, preparation, species, exposure and manipulation remain explicit. · L-Ergothioneine
    plain_language
    The body retained much of the measured exposure.
    primary_references
    Administration of Pure Ergothioneine to Healthy Human Subjects: Uptake, Metabolism, and Effects on Biomarkers of Oxidative Damage and Inflammation. · 2017 · https://pubmed.ncbi.nlm.nih.gov/27488221/ · DOI 10.1089/ars.2016.6778

    Ergothioneine: transport, redox chemistry and cross-nutrient mechanisms (2026-09-19) · lines 464–470

    AI-assisted research curation; primary references, access levels and experimental limitations individually identified. Not publisher full text. · supports · Human oral uptake/pharmacokinetic study. · source_derived_draft · unverified_draft

    ## ergothioneine-human-retention The body retained much of the measured exposure. Oral pure ergothioneine increased plasma and whole-blood concentrations in healthy volunteers, with urinary recovery below 4% of the administered amount. Model: Human oral uptake/pharmacokinetic study. Limitations: Blood measurements do not establish tissue-specific sufficiency. Evidence access: Primary abstract Administration of Pure Ergothioneine to Healthy Human Subjects: Uptake, Metabolism, and Effects on Biomarkers of Oxidative Damage and Inflammation. · 2017 · https://pubmed.ncbi.nlm.nih.gov/27488221/ · DOI 10.1089/ars.2016.6778
    Complete structured claim and evidence

  2. The study also found lower blood ergothioneine in olanzapine-treated patients.

    Olanzapine → Human blood ergothioneine concentration, compartment specified source_derived_draftungraded
    Experimental context and source evidence
    availability_state
    biomarker_context Imported condition classification; unverified.
    evidence_access
    Primary abstract
    experimental_model
    Patient blood comparison within a mainly mechanistic animal study.
    limitations
    Not evidence that supplementation improves cognition in these patients.
    nutrient_topic
    Ergothioneine collection; molecular form, preparation, species, exposure and manipulation remain explicit. · L-Ergothioneine
    plain_language
    A human blood observation accompanied the mouse work.
    primary_references
    Gut microbiota-derived ergothioneine alleviates antipsychotic-induced synaptic and cognitive impairments. · 2026 · https://pubmed.ncbi.nlm.nih.gov/42013837/ · DOI 10.1016/j.chom.2026.03.020
    trigger_kind
    biomarker_context Imported condition classification; unverified.

    Ergothioneine: transport, redox chemistry and cross-nutrient mechanisms (2026-09-19) · lines 432–438

    AI-assisted research curation; primary references, access levels and experimental limitations individually identified. Not publisher full text. · supports · Patient blood comparison within a mainly mechanistic animal study. · source_derived_draft · unverified_draft

    ## ergothioneine-olanzapine-human-marker A human blood observation accompanied the mouse work. The study also found lower blood ergothioneine in olanzapine-treated patients. Model: Patient blood comparison within a mainly mechanistic animal study. Limitations: Not evidence that supplementation improves cognition in these patients. Evidence access: Primary abstract Gut microbiota-derived ergothioneine alleviates antipsychotic-induced synaptic and cognitive impairments. · 2026 · https://pubmed.ncbi.nlm.nih.gov/42013837/ · DOI 10.1016/j.chom.2026.03.020
    Complete structured claim and evidence

In the sources

Preserved passages that mention this component, quoted exactly. Open one to read it in context.

    This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.

    Evidence, AI assistance and curation standards