{"id":"bd346129-254f-51e7-a654-d18f2fb1c9be","stable_key":"59b18080-c560-563d-abc5-bac4ee82a27c:ergothioneine-human-metabolite-markers","predicate":"correlates_with","statement":"Human whole-blood ergothioneine correlated with hercynine and S-methyl-ergothioneine, consistent with possible metabolism.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"ff37b49e-f6e9-57fa-a2e1-3c5147d2ff56","mechanism_event_label":"Related molecules may help trace its fate.","subject":{"id":"953f6383-3113-5db3-8a49-e424f86e7380","slug":"human-blood-ergothioneine","display_name":"Human blood ergothioneine concentration, compartment specified","entity_type_key":"cellular_process"},"object":{"id":"aab91468-fc60-51de-8d6a-0dcd2096d6f8","slug":"s-methyl-ergothioneine","display_name":"S-Methyl-ergothioneine","entity_type_key":"small_molecule"},"evidence_count":1,"mechanism_event":{"id":"ff37b49e-f6e9-57fa-a2e1-3c5147d2ff56","stable_key":"59b18080-c560-563d-abc5-bac4ee82a27c:ergothioneine-human-metabolite-markers-event","event_type":"observed_relationship","label":"Related molecules may help trace its fate.","description":"Human whole-blood ergothioneine correlated with hercynine and S-methyl-ergothioneine, consistent with possible metabolism.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"953f6383-3113-5db3-8a49-e424f86e7380","slug":"human-blood-ergothioneine","display_name":"Human blood ergothioneine concentration, compartment specified","entity_type_key":"cellular_process"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"aab91468-fc60-51de-8d6a-0dcd2096d6f8","slug":"s-methyl-ergothioneine","display_name":"S-Methyl-ergothioneine","entity_type_key":"small_molecule"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"939c92c3-50ea-5a4a-9654-8e3b94448132","slug":"ergothioneine","display_name":"L-Ergothioneine","entity_type_key":"small_molecule"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""},{"entity":{"id":"b3583649-cbbd-50f1-be33-26b1ee0dd6ab","slug":"hercynine","display_name":"Hercynine / N-alpha-trimethylhistidine","entity_type_key":"small_molecule"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":3,"notes":""}]},"contexts":[{"dimension":"availability_state","value_text":"biomarker_context","comparator":null,"unit":null,"notes":"Imported condition classification; unverified.","entity":null},{"dimension":"evidence_access","value_text":"Primary abstract","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Human oral-administration study.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Correlation does not identify the human enzymes or prove every conversion direction.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Ergothioneine collection; molecular form, preparation, species, exposure and manipulation remain explicit.","comparator":null,"unit":null,"notes":"","entity":{"slug":"ergothioneine","display_name":"L-Ergothioneine","entity_type_key":"small_molecule"}},{"dimension":"plain_language","value_text":"Related molecules may help trace its fate.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"Administration of Pure Ergothioneine to Healthy Human Subjects: Uptake, Metabolism, and Effects on Biomarkers of Oxidative Damage and Inflammation. · 2017 · https://pubmed.ncbi.nlm.nih.gov/27488221/ · DOI 10.1089/ars.2016.6778","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"trigger_kind","value_text":"biomarker_context","comparator":null,"unit":null,"notes":"Imported condition classification; 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