{"id":"2c3f6013-4eac-5b0a-ae10-533e7f6e90f9","stable_key":"59b18080-c560-563d-abc5-bac4ee82a27c:ergothioneine-human-retention","predicate":"increases","statement":"Oral pure ergothioneine increased plasma and whole-blood concentrations in healthy volunteers, with urinary recovery below 4% of the administered amount.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"positive","is_public":true,"mechanism_event_id":"1732a1d6-094b-5049-94de-051a58253bd0","mechanism_event_label":"The body retained much of the measured exposure.","subject":{"id":"939c92c3-50ea-5a4a-9654-8e3b94448132","slug":"ergothioneine","display_name":"L-Ergothioneine","entity_type_key":"small_molecule"},"object":{"id":"953f6383-3113-5db3-8a49-e424f86e7380","slug":"human-blood-ergothioneine","display_name":"Human blood ergothioneine concentration, compartment specified","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"1732a1d6-094b-5049-94de-051a58253bd0","stable_key":"59b18080-c560-563d-abc5-bac4ee82a27c:ergothioneine-human-retention-event","event_type":"observed_relationship","label":"The body retained much of the measured exposure.","description":"Oral pure ergothioneine increased plasma and whole-blood concentrations in healthy volunteers, with urinary recovery below 4% of the administered amount.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"939c92c3-50ea-5a4a-9654-8e3b94448132","slug":"ergothioneine","display_name":"L-Ergothioneine","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"953f6383-3113-5db3-8a49-e424f86e7380","slug":"human-blood-ergothioneine","display_name":"Human blood ergothioneine concentration, compartment specified","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""}]},"contexts":[{"dimension":"evidence_access","value_text":"Primary abstract","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Human oral uptake/pharmacokinetic study.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Blood measurements do not establish tissue-specific sufficiency.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Ergothioneine collection; molecular form, preparation, species, exposure and manipulation remain explicit.","comparator":null,"unit":null,"notes":"","entity":{"slug":"ergothioneine","display_name":"L-Ergothioneine","entity_type_key":"small_molecule"}},{"dimension":"plain_language","value_text":"The body retained much of the measured exposure.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"Administration of Pure Ergothioneine to Healthy Human Subjects: Uptake, Metabolism, and Effects on Biomarkers of Oxidative Damage and Inflammation. · 2017 · https://pubmed.ncbi.nlm.nih.gov/27488221/ · DOI 10.1089/ars.2016.6778","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"994099e6-c942-5735-9ca9-0f7bbd5b8ed9","evidence_kind":"source_excerpt","locator":"Lines 464-470","start_line":464,"end_line":470,"excerpt":"## ergothioneine-human-retention\nThe body retained much of the measured exposure.\nOral pure ergothioneine increased plasma and whole-blood concentrations in healthy volunteers, with urinary recovery below 4% of the administered amount.\nModel: Human oral uptake/pharmacokinetic study.\nLimitations: Blood measurements do not establish tissue-specific sufficiency.\nEvidence access: Primary abstract\nAdministration of Pure Ergothioneine to Healthy Human Subjects: Uptake, Metabolism, and Effects on Biomarkers of Oxidative Damage and Inflammation. · 2017 · https://pubmed.ncbi.nlm.nih.gov/27488221/ · DOI 10.1089/ars.2016.6778","model_system":"Human oral uptake/pharmacokinetic study.","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Original curation paraphrase; evidence access and experimental limitations specified.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"2f037d98-f3d0-5dbe-80d8-90b738f130d6","stable_key":"import-59b18080-c560-563d-abc5-bac4ee82a27c","title":"Ergothioneine: transport, redox chemistry and cross-nutrient mechanisms (2026-09-19)","document_type":"imported_text","citation_label":"AI-assisted research curation; primary references, access levels and experimental limitations individually identified. Not publisher full text.","file_path":"","sha256":"b6def8119f03cfabeec2fb55ba924340dc612e1dd42f05404201fa2b7ced5259","revision_id":"f88c38e6-ffb5-5a68-83ca-4610ca2c2df4","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}