Component
Human adipocyte insulin-stimulated glucose uptake
Context-specific entity; species, compartment and exposure are stated on each claim.
2 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
What acts on it
p65 siRNA depletion attenuated CLA-induced loss of GLUT4 and PPAR-gamma proteins and suppression of glucose uptake.
Experimental context and source evidence
- evidence_access
- Primary abstract
- experimental_model
- Human adipocyte RNA-interference experiment.
- limitations
- Supports a contribution in this model, not universal necessity in all tissues.
- nutrient_topic
- CLA collection; isomer, preparation, species, exposure and manipulation remain explicit. · Conjugated linoleic acid / CLA isomer family
- plain_language
- Removing a signaling component weakened the adverse response.
- primary_references
- Conjugated linoleic acid promotes human adipocyte insulin resistance through NFkappaB-dependent cytokine production. · 2005 · https://pubmed.ncbi.nlm.nih.gov/16155293/ · DOI 10.1074/jbc.M508159200
Conjugated linoleic acid: isomers, signaling, nutrient interactions and discovery (2026-09-19) · lines 142–148
AI-assisted research curation; primary-abstract references and experimental limitations individually identified. Not publisher full text. · supports · Human adipocyte RNA-interference experiment. · source_derived_draft · unverified_draft
## cla-rela-knockdown Removing a signaling component weakened the adverse response. p65 siRNA depletion attenuated CLA-induced loss of GLUT4 and PPAR-gamma proteins and suppression of glucose uptake. Model: Human adipocyte RNA-interference experiment. Limitations: Supports a contribution in this model, not universal necessity in all tissues. Evidence access: Primary abstract Conjugated linoleic acid promotes human adipocyte insulin resistance through NFkappaB-dependent cytokine production. · 2005 · https://pubmed.ncbi.nlm.nih.gov/16155293/ · DOI 10.1074/jbc.M508159200
Complete structured claim and evidence
Where it participates (unsigned role)
Adding t10,c12 CLA reduced GLUT4 gene expression and insulin-stimulated glucose uptake and oxidation.
Experimental context and source evidence
- evidence_access
- Primary abstract
- experimental_model
- Primary cultures of differentiating human preadipocytes.
- limitations
- Reduced fat storage is not automatically improved metabolic health.
- nutrient_topic
- CLA collection; isomer, preparation, species, exposure and manipulation remain explicit. · Conjugated linoleic acid / CLA isomer family
- plain_language
- Less glucose entered the fat cells in response to insulin.
- primary_references
- Isomer-specific regulation of metabolism and PPARgamma signaling by CLA in human preadipocytes. · 2003 · https://pubmed.ncbi.nlm.nih.gov/12730300/ · DOI 10.1194/jlr.M300001-JLR200
Conjugated linoleic acid: isomers, signaling, nutrient interactions and discovery (2026-09-19) · lines 70–76
AI-assisted research curation; primary-abstract references and experimental limitations individually identified. Not publisher full text. · supports · Primary cultures of differentiating human preadipocytes. · source_derived_draft · unverified_draft
## cla-glut4 Less glucose entered the fat cells in response to insulin. Adding t10,c12 CLA reduced GLUT4 gene expression and insulin-stimulated glucose uptake and oxidation. Model: Primary cultures of differentiating human preadipocytes. Limitations: Reduced fat storage is not automatically improved metabolic health. Evidence access: Primary abstract Isomer-specific regulation of metabolism and PPARgamma signaling by CLA in human preadipocytes. · 2003 · https://pubmed.ncbi.nlm.nih.gov/12730300/ · DOI 10.1194/jlr.M300001-JLR200
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.