Component

Human melatonin-related orphan receptor / GPR50

Human melatonin-related orphan receptor / GPR50. Species, exposure and limitations are retained in each linked claim.

5 recorded relationships. Experimental role, claim status and evidence remain attached to each record.

Read recorded mechanisms Open recursive mind map

How nutrients influence it

Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.

How nutrients reach it in more than one step

Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.

Tracing routes…

What it does

Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.

Recorded relationships

What it acts on

  1. GPR50 abolished MT1 high-affinity agonist binding within the heterodimer.

    Human melatonin-related orphan receptor / GPR50 → MT1 high-affinity agonist binding source_derived_draftungraded
    Experimental context and source evidence
    availability_state
    machinery_impairment Imported condition classification; unverified.
    evidence_span
    {"source_cache": "artifacts/melatonin-research/16778767.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "19c9ae903fb7926bb21cc3bda0a610612b16a899f850b8e787581b72ac434135", "start_char": 0, "end_char": 1204, "text_sha256": "19c9ae903fb7926bb21cc3bda0a610612b16a899f850b8e787581b72ac434135"}
    experimental_model
    Biochemical and biophysical receptor heteromer experiments
    exposure
    Full-length versus C-terminally truncated GPR50
    limitations
    Cell-system regulation; does not establish that a person with poor sleep has excess GPR50 or that more melatonin overcomes it.
    nutrient_topic
    Melatonin research collection; topical membership is not evidence of a direct dietary effect. · Melatonin
    organism
    Human receptors in cultured cells
    plain_language
    Available hormone and functional receptor machinery are different requirements.
    primary_references
    [melatonin-p16778767] The orphan GPR50 receptor specifically inhibits MT1 melatonin receptor function through heterodimerization. (2006). https://pubmed.ncbi.nlm.nih.gov/16778767/ DOI: 10.1038/sj.emboj.7601193
    tissue_or_cell_type
    GPR50-MT1/MT2 interactions
    trigger_kind
    machinery_impairment Imported condition classification; unverified.

    Melatonin: synthesis, receptors, circadian timing and nutrient interactions (2026-09-17) · lines 448–459

    AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Biochemical and biophysical receptor heteromer experiments · source_derived_draft · unverified_draft

    ### melatonin-gpr50-mt1-binding GPR50 abolished MT1 high-affinity agonist binding within the heterodimer. Condition category: machinery_impairment nutrient_topic: Melatonin research collection; topical membership is not evidence of a direct dietary effect. plain_language: Available hormone and functional receptor machinery are different requirements. organism: Human receptors in cultured cells tissue_or_cell_type: GPR50-MT1/MT2 interactions experimental_model: Biochemical and biophysical receptor heteromer experiments limitations: Cell-system regulation; does not establish that a person with poor sleep has excess GPR50 or that more melatonin overcomes it. exposure: Full-length versus C-terminally truncated GPR50 evidence_span: {"source_cache": "artifacts/melatonin-research/16778767.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "19c9ae903fb7926bb21cc3bda0a610612b16a899f850b8e787581b72ac434135", "start_char": 0, "end_char": 1204, "text_sha256": "19c9ae903fb7926bb21cc3bda0a610612b16a899f850b8e787581b72ac434135"} [melatonin-p16778767] The orphan GPR50 receptor specifically inhibits MT1 melatonin receptor function through heterodimerization. (2006). https://pubmed.ncbi.nlm.nih.gov/16778767/ DOI: 10.1038/sj.emboj.7601193
    Complete structured claim and evidence

  2. GPR50 abolished MT1 G-protein coupling within the heterodimer.

    Human melatonin-related orphan receptor / GPR50 → MT1 coupling to inhibitory G proteins source_derived_draftungraded
    Experimental context and source evidence
    availability_state
    machinery_impairment Imported condition classification; unverified.
    evidence_span
    {"source_cache": "artifacts/melatonin-research/16778767.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "19c9ae903fb7926bb21cc3bda0a610612b16a899f850b8e787581b72ac434135", "start_char": 0, "end_char": 1204, "text_sha256": "19c9ae903fb7926bb21cc3bda0a610612b16a899f850b8e787581b72ac434135"}
    experimental_model
    Biochemical and biophysical receptor heteromer experiments
    exposure
    Full-length versus C-terminally truncated GPR50
    limitations
    Cell-system regulation; does not establish that a person with poor sleep has excess GPR50 or that more melatonin overcomes it.
    nutrient_topic
    Melatonin research collection; topical membership is not evidence of a direct dietary effect. · Melatonin
    organism
    Human receptors in cultured cells
    plain_language
    Available hormone and functional receptor machinery are different requirements.
    primary_references
    [melatonin-p16778767] The orphan GPR50 receptor specifically inhibits MT1 melatonin receptor function through heterodimerization. (2006). https://pubmed.ncbi.nlm.nih.gov/16778767/ DOI: 10.1038/sj.emboj.7601193
    tissue_or_cell_type
    GPR50-MT1/MT2 interactions
    trigger_kind
    machinery_impairment Imported condition classification; unverified.

    Melatonin: synthesis, receptors, circadian timing and nutrient interactions (2026-09-17) · lines 461–472

    AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Biochemical and biophysical receptor heteromer experiments · source_derived_draft · unverified_draft

    ### melatonin-gpr50-mt1-coupling GPR50 abolished MT1 G-protein coupling within the heterodimer. Condition category: machinery_impairment nutrient_topic: Melatonin research collection; topical membership is not evidence of a direct dietary effect. plain_language: Available hormone and functional receptor machinery are different requirements. organism: Human receptors in cultured cells tissue_or_cell_type: GPR50-MT1/MT2 interactions experimental_model: Biochemical and biophysical receptor heteromer experiments limitations: Cell-system regulation; does not establish that a person with poor sleep has excess GPR50 or that more melatonin overcomes it. exposure: Full-length versus C-terminally truncated GPR50 evidence_span: {"source_cache": "artifacts/melatonin-research/16778767.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "19c9ae903fb7926bb21cc3bda0a610612b16a899f850b8e787581b72ac434135", "start_char": 0, "end_char": 1204, "text_sha256": "19c9ae903fb7926bb21cc3bda0a610612b16a899f850b8e787581b72ac434135"} [melatonin-p16778767] The orphan GPR50 receptor specifically inhibits MT1 melatonin receptor function through heterodimerization. (2006). https://pubmed.ncbi.nlm.nih.gov/16778767/ DOI: 10.1038/sj.emboj.7601193
    Complete structured claim and evidence

  3. GPR50 formed heterodimers with MT1 in the tested cell systems.

    Human melatonin-related orphan receptor / GPR50 → Human melatonin receptor 1A / MT1 / MTNR1A source_derived_draftungraded
    Experimental context and source evidence
    evidence_span
    {"source_cache": "artifacts/melatonin-research/16778767.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "19c9ae903fb7926bb21cc3bda0a610612b16a899f850b8e787581b72ac434135", "start_char": 0, "end_char": 1204, "text_sha256": "19c9ae903fb7926bb21cc3bda0a610612b16a899f850b8e787581b72ac434135"}
    experimental_model
    Biochemical and biophysical receptor heteromer experiments
    exposure
    Full-length versus C-terminally truncated GPR50
    limitations
    Cell-system regulation; does not establish that a person with poor sleep has excess GPR50 or that more melatonin overcomes it.
    nutrient_topic
    Melatonin research collection; topical membership is not evidence of a direct dietary effect. · Melatonin
    organism
    Human receptors in cultured cells
    plain_language
    A receptor partner can alter access to a signaling route.
    primary_references
    [melatonin-p16778767] The orphan GPR50 receptor specifically inhibits MT1 melatonin receptor function through heterodimerization. (2006). https://pubmed.ncbi.nlm.nih.gov/16778767/ DOI: 10.1038/sj.emboj.7601193
    tissue_or_cell_type
    GPR50-MT1/MT2 interactions

    Melatonin: synthesis, receptors, circadian timing and nutrient interactions (2026-09-17) · lines 422–433

    AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Biochemical and biophysical receptor heteromer experiments · source_derived_draft · unverified_draft

    ### melatonin-gpr50-mt1-heteromer GPR50 formed heterodimers with MT1 in the tested cell systems. Condition category: normal nutrient_topic: Melatonin research collection; topical membership is not evidence of a direct dietary effect. plain_language: A receptor partner can alter access to a signaling route. organism: Human receptors in cultured cells tissue_or_cell_type: GPR50-MT1/MT2 interactions experimental_model: Biochemical and biophysical receptor heteromer experiments limitations: Cell-system regulation; does not establish that a person with poor sleep has excess GPR50 or that more melatonin overcomes it. exposure: Full-length versus C-terminally truncated GPR50 evidence_span: {"source_cache": "artifacts/melatonin-research/16778767.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "19c9ae903fb7926bb21cc3bda0a610612b16a899f850b8e787581b72ac434135", "start_char": 0, "end_char": 1204, "text_sha256": "19c9ae903fb7926bb21cc3bda0a610612b16a899f850b8e787581b72ac434135"} [melatonin-p16778767] The orphan GPR50 receptor specifically inhibits MT1 melatonin receptor function through heterodimerization. (2006). https://pubmed.ncbi.nlm.nih.gov/16778767/ DOI: 10.1038/sj.emboj.7601193
    Complete structured claim and evidence

  4. GPR50 formed heterodimers with MT2 in the same study.

    Human melatonin-related orphan receptor / GPR50 → Human melatonin receptor 1B / MT2 / MTNR1B source_derived_draftungraded
    Experimental context and source evidence
    evidence_span
    {"source_cache": "artifacts/melatonin-research/16778767.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "19c9ae903fb7926bb21cc3bda0a610612b16a899f850b8e787581b72ac434135", "start_char": 0, "end_char": 1204, "text_sha256": "19c9ae903fb7926bb21cc3bda0a610612b16a899f850b8e787581b72ac434135"}
    experimental_model
    Biochemical and biophysical receptor heteromer experiments
    exposure
    Full-length versus C-terminally truncated GPR50
    limitations
    Cell-system regulation; does not establish that a person with poor sleep has excess GPR50 or that more melatonin overcomes it.
    nutrient_topic
    Melatonin research collection; topical membership is not evidence of a direct dietary effect. · Melatonin
    organism
    Human receptors in cultured cells
    plain_language
    Physical partnership alone does not establish functional inhibition.
    primary_references
    [melatonin-p16778767] The orphan GPR50 receptor specifically inhibits MT1 melatonin receptor function through heterodimerization. (2006). https://pubmed.ncbi.nlm.nih.gov/16778767/ DOI: 10.1038/sj.emboj.7601193
    tissue_or_cell_type
    GPR50-MT1/MT2 interactions

    Melatonin: synthesis, receptors, circadian timing and nutrient interactions (2026-09-17) · lines 435–446

    AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Biochemical and biophysical receptor heteromer experiments · source_derived_draft · unverified_draft

    ### melatonin-gpr50-mt2-heteromer GPR50 formed heterodimers with MT2 in the same study. Condition category: normal nutrient_topic: Melatonin research collection; topical membership is not evidence of a direct dietary effect. plain_language: Physical partnership alone does not establish functional inhibition. organism: Human receptors in cultured cells tissue_or_cell_type: GPR50-MT1/MT2 interactions experimental_model: Biochemical and biophysical receptor heteromer experiments limitations: Cell-system regulation; does not establish that a person with poor sleep has excess GPR50 or that more melatonin overcomes it. exposure: Full-length versus C-terminally truncated GPR50 evidence_span: {"source_cache": "artifacts/melatonin-research/16778767.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "19c9ae903fb7926bb21cc3bda0a610612b16a899f850b8e787581b72ac434135", "start_char": 0, "end_char": 1204, "text_sha256": "19c9ae903fb7926bb21cc3bda0a610612b16a899f850b8e787581b72ac434135"} [melatonin-p16778767] The orphan GPR50 receptor specifically inhibits MT1 melatonin receptor function through heterodimerization. (2006). https://pubmed.ncbi.nlm.nih.gov/16778767/ DOI: 10.1038/sj.emboj.7601193
    Complete structured claim and evidence

  5. Association with GPR50 did not modify MT2 function in the experiment.

    Human melatonin-related orphan receptor / GPR50 → MT2 agonist binding and signaling in heteromer experiments source_derived_draftungraded
    Experimental context and source evidence
    evidence_span
    {"source_cache": "artifacts/melatonin-research/16778767.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "19c9ae903fb7926bb21cc3bda0a610612b16a899f850b8e787581b72ac434135", "start_char": 0, "end_char": 1204, "text_sha256": "19c9ae903fb7926bb21cc3bda0a610612b16a899f850b8e787581b72ac434135"}
    experimental_model
    Biochemical and biophysical receptor heteromer experiments
    exposure
    Full-length versus C-terminally truncated GPR50
    limitations
    Cell-system regulation; does not establish that a person with poor sleep has excess GPR50 or that more melatonin overcomes it.
    nutrient_topic
    Melatonin research collection; topical membership is not evidence of a direct dietary effect. · Melatonin
    organism
    Human receptors in cultured cells
    plain_language
    The inhibition was receptor-subtype-specific.
    primary_references
    [melatonin-p16778767] The orphan GPR50 receptor specifically inhibits MT1 melatonin receptor function through heterodimerization. (2006). https://pubmed.ncbi.nlm.nih.gov/16778767/ DOI: 10.1038/sj.emboj.7601193
    tissue_or_cell_type
    GPR50-MT1/MT2 interactions

    Melatonin: synthesis, receptors, circadian timing and nutrient interactions (2026-09-17) · lines 474–485

    AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Biochemical and biophysical receptor heteromer experiments · source_derived_draft · unverified_draft

    ### melatonin-gpr50-mt2-null Association with GPR50 did not modify MT2 function in the experiment. Condition category: normal nutrient_topic: Melatonin research collection; topical membership is not evidence of a direct dietary effect. plain_language: The inhibition was receptor-subtype-specific. organism: Human receptors in cultured cells tissue_or_cell_type: GPR50-MT1/MT2 interactions experimental_model: Biochemical and biophysical receptor heteromer experiments limitations: Cell-system regulation; does not establish that a person with poor sleep has excess GPR50 or that more melatonin overcomes it. exposure: Full-length versus C-terminally truncated GPR50 evidence_span: {"source_cache": "artifacts/melatonin-research/16778767.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "19c9ae903fb7926bb21cc3bda0a610612b16a899f850b8e787581b72ac434135", "start_char": 0, "end_char": 1204, "text_sha256": "19c9ae903fb7926bb21cc3bda0a610612b16a899f850b8e787581b72ac434135"} [melatonin-p16778767] The orphan GPR50 receptor specifically inhibits MT1 melatonin receptor function through heterodimerization. (2006). https://pubmed.ncbi.nlm.nih.gov/16778767/ DOI: 10.1038/sj.emboj.7601193
    Complete structured claim and evidence

In the sources

Preserved passages that mention this component, quoted exactly. Open one to read it in context.

    This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.

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