Component
MT1 coupling to inhibitory G proteins
MT1 coupling to inhibitory G proteins. Species, exposure and limitations are retained in each linked claim.
1 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
What acts on it
GPR50 abolished MT1 G-protein coupling within the heterodimer.
Experimental context and source evidence
- availability_state
- machinery_impairment Imported condition classification; unverified.
- evidence_span
- {"source_cache": "artifacts/melatonin-research/16778767.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "19c9ae903fb7926bb21cc3bda0a610612b16a899f850b8e787581b72ac434135", "start_char": 0, "end_char": 1204, "text_sha256": "19c9ae903fb7926bb21cc3bda0a610612b16a899f850b8e787581b72ac434135"}
- experimental_model
- Biochemical and biophysical receptor heteromer experiments
- exposure
- Full-length versus C-terminally truncated GPR50
- limitations
- Cell-system regulation; does not establish that a person with poor sleep has excess GPR50 or that more melatonin overcomes it.
- nutrient_topic
- Melatonin research collection; topical membership is not evidence of a direct dietary effect. · Melatonin
- organism
- Human receptors in cultured cells
- plain_language
- Available hormone and functional receptor machinery are different requirements.
- primary_references
- [melatonin-p16778767] The orphan GPR50 receptor specifically inhibits MT1 melatonin receptor function through heterodimerization. (2006). https://pubmed.ncbi.nlm.nih.gov/16778767/ DOI: 10.1038/sj.emboj.7601193
- tissue_or_cell_type
- GPR50-MT1/MT2 interactions
- trigger_kind
- machinery_impairment Imported condition classification; unverified.
Melatonin: synthesis, receptors, circadian timing and nutrient interactions (2026-09-17) · lines 461–472
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Biochemical and biophysical receptor heteromer experiments · source_derived_draft · unverified_draft
### melatonin-gpr50-mt1-coupling GPR50 abolished MT1 G-protein coupling within the heterodimer. Condition category: machinery_impairment nutrient_topic: Melatonin research collection; topical membership is not evidence of a direct dietary effect. plain_language: Available hormone and functional receptor machinery are different requirements. organism: Human receptors in cultured cells tissue_or_cell_type: GPR50-MT1/MT2 interactions experimental_model: Biochemical and biophysical receptor heteromer experiments limitations: Cell-system regulation; does not establish that a person with poor sleep has excess GPR50 or that more melatonin overcomes it. exposure: Full-length versus C-terminally truncated GPR50 evidence_span: {"source_cache": "artifacts/melatonin-research/16778767.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "19c9ae903fb7926bb21cc3bda0a610612b16a899f850b8e787581b72ac434135", "start_char": 0, "end_char": 1204, "text_sha256": "19c9ae903fb7926bb21cc3bda0a610612b16a899f850b8e787581b72ac434135"} [melatonin-p16778767] The orphan GPR50 receptor specifically inhibits MT1 melatonin receptor function through heterodimerization. (2006). https://pubmed.ncbi.nlm.nih.gov/16778767/ DOI: 10.1038/sj.emboj.7601193
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.