Component

Fisetin glucuronides, unresolved positional pool

Context-specific entity; species, compartment and exposure are stated on each claim.

3 recorded relationships. Experimental role, claim status and evidence remain attached to each record.

Read recorded mechanisms Open recursive mind map

How nutrients influence it

Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.

How nutrients reach it in more than one step

Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.

Tracing routes…

What it does

Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.

Recorded relationships

What acts on it

  1. The mouse disposition study detected a fisetin glucuronide and a glucuronide of geraldol.

    Fisetin → Fisetin glucuronides, unresolved positional pool source_derived_draftungraded
    Experimental context and source evidence
    evidence_access
    Primary abstract
    experimental_model
    Mouse plasma metabolite identification after intraperitoneal dosing.
    limitations
    Positional conjugate identities remain unresolved here.
    nutrient_topic
    Fisetin collection; molecular form, preparation, species, exposure and manipulation remain explicit. · Fisetin
    plain_language
    Further conjugation changes both the parent and metabolite.
    primary_references
    Fisetin disposition and metabolism in mice: Identification of geraldol as an active metabolite. · 2011 · https://pubmed.ncbi.nlm.nih.gov/21840301/ · DOI 10.1016/j.bcp.2011.07.097

    Fisetin: metabolism, cell-state responses and cross-nutrient mechanisms (2026-09-19) · lines 32–38

    AI-assisted research curation; primary references, access levels and experimental limitations individually identified. Not publisher full text. · supports · Mouse plasma metabolite identification after intraperitoneal dosing. · source_derived_draft · unverified_draft

    ## fisetin-mouse-conjugates Further conjugation changes both the parent and metabolite. The mouse disposition study detected a fisetin glucuronide and a glucuronide of geraldol. Model: Mouse plasma metabolite identification after intraperitoneal dosing. Limitations: Positional conjugate identities remain unresolved here. Evidence access: Primary abstract Fisetin disposition and metabolism in mice: Identification of geraldol as an active metabolite. · 2011 · https://pubmed.ncbi.nlm.nih.gov/21840301/ · DOI 10.1016/j.bcp.2011.07.097
    Complete structured claim and evidence

Where it participates (unsigned role)

  1. Rat bile contained mainly sulfated fisetin metabolites; the study also implicated P-glycoprotein in fisetin biliary excretion.

    Rat biliary export of fisetin-related compounds → Fisetin sulfates, unresolved positional pool source_derived_draftungraded
    Experimental context and source evidence
    evidence_access
    Primary abstract
    experimental_model
    Cannulated rat bile-duct pharmacokinetic study.
    limitations
    The reported AUC-based biliary ratio is not a fraction of dose recovered; transporter isoform was not resolved in the abstract.
    nutrient_topic
    Fisetin collection; molecular form, preparation, species, exposure and manipulation remain explicit. · Fisetin
    plain_language
    Transport and conjugation shape elimination.
    primary_references
    Pharmacokinetics and Biliary Excretion of Fisetin in Rats. · 2018 · https://pubmed.ncbi.nlm.nih.gov/29862816/ · DOI 10.1021/acs.jafc.8b00917
    transport_effect
    lowers Biliary excretion of sulfated fisetin metabolites, which removes them from the body compartment the chapter follows.
    transport_pool
    the hepatocyte and the systemic circulation Biliary excretion of sulfated fisetin metabolites, which removes them from the body compartment the chapter follows.

    Fisetin: metabolism, cell-state responses and cross-nutrient mechanisms (2026-09-19) · lines 64–70

    AI-assisted research curation; primary references, access levels and experimental limitations individually identified. Not publisher full text. · supports · Cannulated rat bile-duct pharmacokinetic study. · source_derived_draft · unverified_draft

    ## fisetin-rat-biliary-clearance Transport and conjugation shape elimination. Rat bile contained mainly sulfated fisetin metabolites; the study also implicated P-glycoprotein in fisetin biliary excretion. Model: Cannulated rat bile-duct pharmacokinetic study. Limitations: The reported AUC-based biliary ratio is not a fraction of dose recovered; transporter isoform was not resolved in the abstract. Evidence access: Primary abstract Pharmacokinetics and Biliary Excretion of Fisetin in Rats. · 2018 · https://pubmed.ncbi.nlm.nih.gov/29862816/ · DOI 10.1021/acs.jafc.8b00917
    Complete structured claim and evidence

  2. After 30 mg/kg intravenous fisetin in rats, plasma AUC ratios for free fisetin, glucuronides and sulfates were approximately 1:6:21.

    Fisetin → Fisetin sulfates, unresolved positional pool source_derived_draftungraded
    Experimental context and source evidence
    evidence_access
    Primary abstract
    experimental_model
    Male Sprague-Dawley rats; phase-II analytical pools.
    limitations
    No particular human SULT or UGT isoform is established by this result.
    nutrient_topic
    Fisetin collection; molecular form, preparation, species, exposure and manipulation remain explicit. · Fisetin
    plain_language
    Most measured circulating material was conjugated.
    primary_references
    Pharmacokinetics and Biliary Excretion of Fisetin in Rats. · 2018 · https://pubmed.ncbi.nlm.nih.gov/29862816/ · DOI 10.1021/acs.jafc.8b00917

    Fisetin: metabolism, cell-state responses and cross-nutrient mechanisms (2026-09-19) · lines 56–62

    AI-assisted research curation; primary references, access levels and experimental limitations individually identified. Not publisher full text. · supports · Male Sprague-Dawley rats; phase-II analytical pools. · source_derived_draft · unverified_draft

    ## fisetin-rat-conjugate-dominance Most measured circulating material was conjugated. After 30 mg/kg intravenous fisetin in rats, plasma AUC ratios for free fisetin, glucuronides and sulfates were approximately 1:6:21. Model: Male Sprague-Dawley rats; phase-II analytical pools. Limitations: No particular human SULT or UGT isoform is established by this result. Evidence access: Primary abstract Pharmacokinetics and Biliary Excretion of Fisetin in Rats. · 2018 · https://pubmed.ncbi.nlm.nih.gov/29862816/ · DOI 10.1021/acs.jafc.8b00917
    Complete structured claim and evidence

In the sources

Preserved passages that mention this component, quoted exactly. Open one to read it in context.

    This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.

    Evidence, AI assistance and curation standards