{"id":"c66c9d25-7190-52ab-bedc-693b3d1c41a4","stable_key":"74ef5bba-ee14-531c-b1bf-d1f297c56bb6:fisetin-mouse-conjugates","predicate":"forms_conjugates","statement":"The mouse disposition study detected a fisetin glucuronide and a glucuronide of geraldol.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"34e86edb-0cdc-5b9b-86f0-c6717331f5b5","mechanism_event_label":"Further conjugation changes both the parent and metabolite.","subject":{"id":"dee05061-c3f3-5226-8054-dd58b76a585d","slug":"fisetin","display_name":"Fisetin","entity_type_key":"small_molecule"},"object":{"id":"2c6bd5cf-a687-5885-9774-13d2f361c2dc","slug":"fisetin-glucuronides","display_name":"Fisetin glucuronides, unresolved positional pool","entity_type_key":"small_molecule"},"evidence_count":1,"mechanism_event":{"id":"34e86edb-0cdc-5b9b-86f0-c6717331f5b5","stable_key":"74ef5bba-ee14-531c-b1bf-d1f297c56bb6:fisetin-mouse-conjugates-event","event_type":"observed_relationship","label":"Further conjugation changes both the parent and metabolite.","description":"The mouse disposition study detected a fisetin glucuronide and a glucuronide of geraldol.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"dee05061-c3f3-5226-8054-dd58b76a585d","slug":"fisetin","display_name":"Fisetin","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"2c6bd5cf-a687-5885-9774-13d2f361c2dc","slug":"fisetin-glucuronides","display_name":"Fisetin glucuronides, unresolved positional pool","entity_type_key":"small_molecule"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"9fdb2610-ab87-5de2-9658-ed83bc42b3fc","slug":"geraldol","display_name":"Geraldol / 3-prime-O-methylfisetin","entity_type_key":"small_molecule"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""},{"entity":{"id":"71bda17c-5977-5933-921c-e7a8e75154e5","slug":"geraldol-glucuronides","display_name":"Geraldol glucuronides, unresolved positional pool","entity_type_key":"small_molecule"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":3,"notes":""},{"entity":{"id":"fea4f3f0-7c05-59a2-9332-445b9d4f8fb0","slug":"udp-glucuronic-acid","display_name":"UDP-glucuronic acid","entity_type_key":"small_molecule"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":4,"notes":""}]},"contexts":[{"dimension":"evidence_access","value_text":"Primary abstract","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Mouse plasma metabolite identification after intraperitoneal dosing.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Positional conjugate identities remain unresolved here.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Fisetin collection; molecular form, preparation, species, exposure and manipulation remain explicit.","comparator":null,"unit":null,"notes":"","entity":{"slug":"fisetin","display_name":"Fisetin","entity_type_key":"small_molecule"}},{"dimension":"plain_language","value_text":"Further conjugation changes both the parent and metabolite.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"Fisetin disposition and metabolism in mice: Identification of geraldol as an active metabolite. · 2011 · https://pubmed.ncbi.nlm.nih.gov/21840301/ · DOI 10.1016/j.bcp.2011.07.097","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"74a1f447-0d3a-5130-9c30-3cde4f88916b","evidence_kind":"source_excerpt","locator":"Lines 32-38","start_line":32,"end_line":38,"excerpt":"## fisetin-mouse-conjugates\nFurther conjugation changes both the parent and metabolite.\nThe mouse disposition study detected a fisetin glucuronide and a glucuronide of geraldol.\nModel: Mouse plasma metabolite identification after intraperitoneal dosing.\nLimitations: Positional conjugate identities remain unresolved here.\nEvidence access: Primary abstract\nFisetin disposition and metabolism in mice: Identification of geraldol as an active metabolite. · 2011 · https://pubmed.ncbi.nlm.nih.gov/21840301/ · DOI 10.1016/j.bcp.2011.07.097","model_system":"Mouse plasma metabolite identification after intraperitoneal dosing.","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Original curation paraphrase; evidence access and experimental limitations specified.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"1108bfff-6504-5152-a51f-ff3d7c27c282","stable_key":"import-74ef5bba-ee14-531c-b1bf-d1f297c56bb6","title":"Fisetin: metabolism, cell-state responses and cross-nutrient mechanisms (2026-09-19)","document_type":"imported_text","citation_label":"AI-assisted research curation; primary references, access levels and experimental limitations individually identified. Not publisher full text.","file_path":"","sha256":"c30e0764cd34bd062cfcbfaf32357ef29dfda30e7d4153c545178140f5054e09","revision_id":"40ff52c0-f4b9-5820-8abb-ff002c6364a4","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}