{"id":"a79861a3-e70a-5540-8929-83dfc2239a83","stable_key":"74ef5bba-ee14-531c-b1bf-d1f297c56bb6:fisetin-rat-biliary-clearance","predicate":"exports","statement":"Rat bile contained mainly sulfated fisetin metabolites; the study also implicated P-glycoprotein in fisetin biliary excretion.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"5fcf5f95-857c-549e-b119-8530e1b9726f","mechanism_event_label":"Transport and conjugation shape elimination.","subject":{"id":"f522ead5-76ff-537c-9495-c6560f239cf8","slug":"rat-fisetin-biliary-export","display_name":"Rat biliary export of fisetin-related compounds","entity_type_key":"cellular_process"},"object":{"id":"19e5aace-9999-5bdf-88ed-4cdde24cfffc","slug":"fisetin-sulfates","display_name":"Fisetin sulfates, unresolved positional pool","entity_type_key":"small_molecule"},"evidence_count":1,"mechanism_event":{"id":"5fcf5f95-857c-549e-b119-8530e1b9726f","stable_key":"74ef5bba-ee14-531c-b1bf-d1f297c56bb6:fisetin-rat-biliary-clearance-event","event_type":"observed_relationship","label":"Transport and conjugation shape elimination.","description":"Rat bile contained mainly sulfated fisetin metabolites; 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transporter isoform was not resolved in the abstract.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Fisetin collection; molecular form, preparation, species, exposure and manipulation remain explicit.","comparator":null,"unit":null,"notes":"","entity":{"slug":"fisetin","display_name":"Fisetin","entity_type_key":"small_molecule"}},{"dimension":"plain_language","value_text":"Transport and conjugation shape elimination.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"Pharmacokinetics and Biliary Excretion of Fisetin in Rats. · 2018 · https://pubmed.ncbi.nlm.nih.gov/29862816/ · DOI 10.1021/acs.jafc.8b00917","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"transport_effect","value_text":"lowers","comparator":null,"unit":null,"notes":"Biliary excretion of sulfated fisetin metabolites, which removes them from the body compartment the chapter follows.","entity":null},{"dimension":"transport_pool","value_text":"the hepatocyte and the systemic circulation","comparator":null,"unit":null,"notes":"Biliary excretion of sulfated fisetin metabolites, which removes them from the body compartment the chapter follows.","entity":null}],"evidence":[{"id":"211dcbd9-45fd-5d57-b0ef-d5af9f29c35a","evidence_kind":"source_excerpt","locator":"Lines 64-70","start_line":64,"end_line":70,"excerpt":"## fisetin-rat-biliary-clearance\nTransport and conjugation shape elimination.\nRat bile contained mainly sulfated fisetin metabolites; the study also implicated P-glycoprotein in fisetin biliary excretion.\nModel: Cannulated rat bile-duct pharmacokinetic study.\nLimitations: The reported AUC-based biliary ratio is not a fraction of dose recovered; transporter isoform was not resolved in the abstract.\nEvidence access: Primary abstract\nPharmacokinetics and Biliary Excretion of Fisetin in Rats. · 2018 · https://pubmed.ncbi.nlm.nih.gov/29862816/ · DOI 10.1021/acs.jafc.8b00917","model_system":"Cannulated rat bile-duct pharmacokinetic study.","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Original curation paraphrase; evidence access and experimental limitations specified.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"1108bfff-6504-5152-a51f-ff3d7c27c282","stable_key":"import-74ef5bba-ee14-531c-b1bf-d1f297c56bb6","title":"Fisetin: metabolism, cell-state responses and cross-nutrient mechanisms (2026-09-19)","document_type":"imported_text","citation_label":"AI-assisted research curation; primary references, access levels and experimental limitations individually identified. 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