{"id":"a3499033-ac87-5312-8790-a261d98db320","stable_key":"74ef5bba-ee14-531c-b1bf-d1f297c56bb6:fisetin-rat-conjugate-dominance","predicate":"forms_conjugates","statement":"After 30 mg/kg intravenous fisetin in rats, plasma AUC ratios for free fisetin, glucuronides and sulfates were approximately 1:6:21.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"a8276e43-eef7-51b3-80e8-5d0f347c1cef","mechanism_event_label":"Most measured circulating material was conjugated.","subject":{"id":"dee05061-c3f3-5226-8054-dd58b76a585d","slug":"fisetin","display_name":"Fisetin","entity_type_key":"small_molecule"},"object":{"id":"19e5aace-9999-5bdf-88ed-4cdde24cfffc","slug":"fisetin-sulfates","display_name":"Fisetin sulfates, unresolved positional pool","entity_type_key":"small_molecule"},"evidence_count":1,"mechanism_event":{"id":"a8276e43-eef7-51b3-80e8-5d0f347c1cef","stable_key":"74ef5bba-ee14-531c-b1bf-d1f297c56bb6:fisetin-rat-conjugate-dominance-event","event_type":"observed_relationship","label":"Most measured circulating material was conjugated.","description":"After 30 mg/kg intravenous fisetin in rats, plasma AUC ratios for free fisetin, glucuronides and sulfates were approximately 1:6:21.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"dee05061-c3f3-5226-8054-dd58b76a585d","slug":"fisetin","display_name":"Fisetin","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"19e5aace-9999-5bdf-88ed-4cdde24cfffc","slug":"fisetin-sulfates","display_name":"Fisetin sulfates, unresolved positional pool","entity_type_key":"small_molecule"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"2c6bd5cf-a687-5885-9774-13d2f361c2dc","slug":"fisetin-glucuronides","display_name":"Fisetin glucuronides, unresolved positional pool","entity_type_key":"small_molecule"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""},{"entity":{"id":"3634af03-823b-584f-8e8e-e6ab6e3fbb60","slug":"sulfate","display_name":"Sulfate / SO4(2-)","entity_type_key":"ion"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":3,"notes":""},{"entity":{"id":"44432084-b8c5-5d59-a682-6bc790ebbb6d","slug":"paps","display_name":"3-prime-Phosphoadenosine-5-prime-phosphosulfate / PAPS","entity_type_key":"small_molecule"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":4,"notes":""}]},"contexts":[{"dimension":"evidence_access","value_text":"Primary abstract","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Male Sprague-Dawley rats; phase-II analytical pools.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"No particular human SULT or UGT isoform is established by this result.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Fisetin collection; molecular form, preparation, species, exposure and manipulation remain explicit.","comparator":null,"unit":null,"notes":"","entity":{"slug":"fisetin","display_name":"Fisetin","entity_type_key":"small_molecule"}},{"dimension":"plain_language","value_text":"Most measured circulating material was conjugated.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"Pharmacokinetics and Biliary Excretion of Fisetin in Rats. · 2018 · https://pubmed.ncbi.nlm.nih.gov/29862816/ · DOI 10.1021/acs.jafc.8b00917","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"03e32417-a11a-5ee3-a5fa-fd53e4d71277","evidence_kind":"source_excerpt","locator":"Lines 56-62","start_line":56,"end_line":62,"excerpt":"## fisetin-rat-conjugate-dominance\nMost measured circulating material was conjugated.\nAfter 30 mg/kg intravenous fisetin in rats, plasma AUC ratios for free fisetin, glucuronides and sulfates were approximately 1:6:21.\nModel: Male Sprague-Dawley rats; phase-II analytical pools.\nLimitations: No particular human SULT or UGT isoform is established by this result.\nEvidence access: Primary abstract\nPharmacokinetics and Biliary Excretion of Fisetin in Rats. · 2018 · https://pubmed.ncbi.nlm.nih.gov/29862816/ · DOI 10.1021/acs.jafc.8b00917","model_system":"Male Sprague-Dawley rats; phase-II analytical pools.","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Original curation paraphrase; evidence access and experimental limitations specified.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"1108bfff-6504-5152-a51f-ff3d7c27c282","stable_key":"import-74ef5bba-ee14-531c-b1bf-d1f297c56bb6","title":"Fisetin: metabolism, cell-state responses and cross-nutrient mechanisms (2026-09-19)","document_type":"imported_text","citation_label":"AI-assisted research curation; primary references, access levels and experimental limitations individually identified. Not publisher full text.","file_path":"","sha256":"c30e0764cd34bd062cfcbfaf32357ef29dfda30e7d4153c545178140f5054e09","revision_id":"40ff52c0-f4b9-5820-8abb-ff002c6364a4","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}