Component

Erythrocyte folate concentration

Independently recorded substance, clinical endpoint or assay readout. Claims retain study-specific population and measurement context.

3 recorded relationships. Experimental role, claim status and evidence remain attached to each record.

Read recorded mechanisms Open recursive mind map

How nutrients influence it

Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.

How nutrients reach it in more than one step

Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.

Tracing routes…

What it does

Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.

Recorded relationships

What it acts on

  1. The Bayesian model estimated 25.4 NTDs per 10000 births at RBC folate 500 nmol/L, with risk substantially lower above approximately 1000 nmol/L; this was an estimated population relation.

    Erythrocyte folate concentration → Neural-tube defect incidence source_derived_draftungraded
    Experimental context and source evidence
    availability_state
    biomarker_context Imported condition classification; unverified.
    experimental_model
    Bayesian model combining the Chinese prevention cohort (247831 participants) and a separate blood-response trial (1194 women).
    exposure
    Estimated RBC folate at neural-tube closure; modeled population risk, not a prospective test of an individual threshold.
    limitations
    Estimated concentration at neural-tube closure, assay context and model assumptions matter. Reuses the Chinese intervention cohort; not an independent prevention trial.
    nutrient_topic
    Folate and folic acid research collection; topical membership is not evidence of a direct dietary effect. · Folate (vitamin B9)
    organism
    Homo sapiens
    plain_language
    Red-cell folate helped model population risk; it was not a pass/fail test for an individual pregnancy.
    primary_references
    [fol-crider2014] Population red blood cell folate concentrations for prevention of neural tube defects: Bayesian model (2014). https://pubmed.ncbi.nlm.nih.gov/25073783/ DOI: 10.1136/bmj.g4554
    tissue_or_cell_type
    Human blood or whole-person clinical endpoints
    trigger_kind
    biomarker_context Imported condition classification; unverified.

    Folate and folic acid: mechanisms, deficiency and nutrient interactions (2026-09-17) · lines 1396–1406

    AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Bayesian model combining the Chinese prevention cohort (247831 participants) and a separate blood-response trial (1194 women). · source_derived_draft · unverified_draft

    ### fol-rbc-population-risk-model The Bayesian model estimated 25.4 NTDs per 10000 births at RBC folate 500 nmol/L, with risk substantially lower above approximately 1000 nmol/L; this was an estimated population relation. Condition category: biomarker_context nutrient_topic: Folate and folic acid research collection; topical membership is not evidence of a direct dietary effect. plain_language: Red-cell folate helped model population risk; it was not a pass/fail test for an individual pregnancy. organism: Homo sapiens tissue_or_cell_type: Human blood or whole-person clinical endpoints experimental_model: Bayesian model combining the Chinese prevention cohort (247831 participants) and a separate blood-response trial (1194 women). limitations: Estimated concentration at neural-tube closure, assay context and model assumptions matter. Reuses the Chinese intervention cohort; not an independent prevention trial. exposure: Estimated RBC folate at neural-tube closure; modeled population risk, not a prospective test of an individual threshold. [fol-crider2014] Population red blood cell folate concentrations for prevention of neural tube defects: Bayesian model (2014). https://pubmed.ncbi.nlm.nih.gov/25073783/ DOI: 10.1136/bmj.g4554
    Complete structured claim and evidence

What acts on it

  1. In the single-subject study, serum folate became abnormally low by day 219; RBC folate abnormality was reported at day 413 in the abstract/discussion and day 420 in the Results.

    Folate (vitamin B9) → Erythrocyte folate concentration source_derived_draftungraded
    Experimental context and source evidence
    availability_state
    nutrient_deficiency Imported condition classification; unverified.
    experimental_model
    Single initially folate-replete 58-year-old male self-experiment with serial blood assays and marrow examinations.
    exposure
    Prolonged severe folate restriction, major energy restriction/weight loss, and multiple other nutrient supplements; replete diet plus folic acid during recovery.
    limitations
    Assay-dependent observations in a highly supplemented, initially replete individual with severe weight loss; these timings are not typical-person predictions. The paper gives inconsistent day counts for the RBC laboratory-limit crossing; both locations are retained.
    nutrient_topic
    Folate and folic acid research collection; topical membership is not evidence of a direct dietary effect. · Folate (vitamin B9)
    organism
    Homo sapiens
    plain_language
    Different blood compartments showed the shortage at different times.
    primary_references
    [fol-golding2014] Severe experimental folate deficiency in a human subject - a longitudinal study of biochemical and haematological responses as megaloblastic anaemia develops (2014). https://pubmed.ncbi.nlm.nih.gov/25332850/ DOI: 10.1186/2193-1801-3-442
    tissue_or_cell_type
    Human blood or whole-person clinical endpoints
    trigger_kind
    nutrient_deficiency Imported condition classification; unverified.

    Folate and folic acid: mechanisms, deficiency and nutrient interactions (2026-09-17) · lines 1505–1515

    AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Single initially folate-replete 58-year-old male self-experiment with serial blood assays and marrow examinations. · source_derived_draft · unverified_draft

    ### fol-severe-marker-sequence In the single-subject study, serum folate became abnormally low by day 219; RBC folate abnormality was reported at day 413 in the abstract/discussion and day 420 in the Results. Condition category: nutrient_deficiency nutrient_topic: Folate and folic acid research collection; topical membership is not evidence of a direct dietary effect. plain_language: Different blood compartments showed the shortage at different times. organism: Homo sapiens tissue_or_cell_type: Human blood or whole-person clinical endpoints experimental_model: Single initially folate-replete 58-year-old male self-experiment with serial blood assays and marrow examinations. limitations: Assay-dependent observations in a highly supplemented, initially replete individual with severe weight loss; these timings are not typical-person predictions. The paper gives inconsistent day counts for the RBC laboratory-limit crossing; both locations are retained. exposure: Prolonged severe folate restriction, major energy restriction/weight loss, and multiple other nutrient supplements; replete diet plus folic acid during recovery. [fol-golding2014] Severe experimental folate deficiency in a human subject - a longitudinal study of biochemical and haematological responses as megaloblastic anaemia develops (2014). https://pubmed.ncbi.nlm.nih.gov/25332850/ DOI: 10.1186/2193-1801-3-442
    Complete structured claim and evidence

Where it participates (unsigned role)

  1. B12 plus folic acid increased red-cell folate and decreased total homocysteine by 36%; B12 treatment corrected mild biochemical deficiency.

    Cyanocobalamin → Homocysteine source_derived_draftungraded
    Experimental context and source evidence
    availability_state
    biomarker_context Imported condition classification; unverified.
    cross_nutrient
    Direct combined B12/folic-acid exposure.
    experimental_model
    Double-blind randomized trial: 195 adults aged at least 70 with mild B12 deficiency.
    exposure
    Cyanocobalamin 1000 micrograms/day, cyanocobalamin 1000 micrograms plus folic acid 400 micrograms/day, or placebo for 24 weeks.
    limitations
    The combined group cannot isolate the contribution of folic acid versus B12.
    nutrient_topic
    Vitamin B12 research collection; topical membership is not evidence of a direct dietary effect. · Vitamin B12 (cobalamins)
    organism
    Homo sapiens
    plain_language
    The two connected vitamins changed the shared marker.
    primary_references
    [b12-eussen2006] Effect of oral vitamin B-12 with or without folic acid on cognitive function in older people with mild vitamin B-12 deficiency: a randomized, placebo-controlled trial (2006). https://pubmed.ncbi.nlm.nih.gov/16895884/ DOI: 10.1093/ajcn/84.2.361
    tissue_or_cell_type
    Human blood or whole-person endpoints
    trigger_kind
    biomarker_context Imported condition classification; unverified.

    Vitamin B12: mechanisms, deficiency and nutrient interactions (2026-09-17) · lines 1536–1547

    AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Double-blind randomized trial: 195 adults aged at least 70 with mild B12 deficiency. · source_derived_draft · unverified_draft

    ### b12-eussen-folate-homocysteine B12 plus folic acid increased red-cell folate and decreased total homocysteine by 36%; B12 treatment corrected mild biochemical deficiency. Condition category: biomarker_context nutrient_topic: Vitamin B12 research collection; topical membership is not evidence of a direct dietary effect. plain_language: The two connected vitamins changed the shared marker. organism: Homo sapiens tissue_or_cell_type: Human blood or whole-person endpoints experimental_model: Double-blind randomized trial: 195 adults aged at least 70 with mild B12 deficiency. limitations: The combined group cannot isolate the contribution of folic acid versus B12. exposure: Cyanocobalamin 1000 micrograms/day, cyanocobalamin 1000 micrograms plus folic acid 400 micrograms/day, or placebo for 24 weeks. cross_nutrient: Direct combined B12/folic-acid exposure. [b12-eussen2006] Effect of oral vitamin B-12 with or without folic acid on cognitive function in older people with mild vitamin B-12 deficiency: a randomized, placebo-controlled trial (2006). https://pubmed.ncbi.nlm.nih.gov/16895884/ DOI: 10.1093/ajcn/84.2.361
    Complete structured claim and evidence

In the sources

Preserved passages that mention this component, quoted exactly. Open one to read it in context.

    This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.

    Evidence, AI assistance and curation standards