{"id":"81bc1c7d-7124-5798-9121-19dffbcc5a26","stable_key":"7fc92b9e-9cbf-556e-8719-6b5244625250:b12-eussen-folate-homocysteine","predicate":"with_folic_acid_lowered_homocysteine","statement":"B12 plus folic acid increased red-cell folate and decreased total homocysteine by 36%; B12 treatment corrected mild biochemical deficiency.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"negative","is_public":true,"mechanism_event_id":"64c192aa-1d04-5de9-ae90-5839e1b1a22d","mechanism_event_label":"The two connected vitamins changed the shared marker.","subject":{"id":"4cb4dfbc-6cd9-5bd5-98dc-d0a8fb6cfee4","slug":"cyanocobalamin","display_name":"Cyanocobalamin","entity_type_key":"small_molecule"},"object":{"id":"5b635b42-bc0d-5c54-aa94-9cf76cd0ed47","slug":"homocysteine","display_name":"Homocysteine","entity_type_key":"small_molecule"},"evidence_count":1,"mechanism_event":{"id":"64c192aa-1d04-5de9-ae90-5839e1b1a22d","stable_key":"7fc92b9e-9cbf-556e-8719-6b5244625250:b12-eussen-folate-homocysteine-event","event_type":"observed_intervention","label":"The two connected vitamins changed the shared marker.","description":"B12 plus folic acid increased red-cell folate and decreased total homocysteine by 36%; 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unverified.","entity":null}],"evidence":[{"id":"55fc7dce-eee0-5ff2-92d7-5b5494e73687","evidence_kind":"source_excerpt","locator":"Lines 1536-1547","start_line":1536,"end_line":1547,"excerpt":"### b12-eussen-folate-homocysteine\nB12 plus folic acid increased red-cell folate and decreased total homocysteine by 36%; B12 treatment corrected mild biochemical deficiency.\nCondition category: biomarker_context\nnutrient_topic: Vitamin B12 research collection; topical membership is not evidence of a direct dietary effect.\nplain_language: The two connected vitamins changed the shared marker.\norganism: Homo sapiens\ntissue_or_cell_type: Human blood or whole-person endpoints\nexperimental_model: Double-blind randomized trial: 195 adults aged at least 70 with mild B12 deficiency.\nlimitations: The combined group cannot isolate the contribution of folic acid versus B12.\nexposure: Cyanocobalamin 1000 micrograms/day, cyanocobalamin 1000 micrograms plus folic acid 400 micrograms/day, or placebo for 24 weeks.\ncross_nutrient: Direct combined B12/folic-acid exposure.\n[b12-eussen2006] Effect of oral vitamin B-12 with or without folic acid on cognitive function in older people with mild vitamin B-12 deficiency: a randomized, placebo-controlled trial (2006). https://pubmed.ncbi.nlm.nih.gov/16895884/ DOI: 10.1093/ajcn/84.2.361","model_system":"Double-blind randomized trial: 195 adults aged at least 70 with mild B12 deficiency.","directness":"author_interpretation","verification_status":"source_derived_draft","notes":"Exact curation-document quotation, not publisher quotation. Study references: [b12-eussen2006] Effect of oral vitamin B-12 with or without folic acid on cognitive function in older people with mild vitamin B-12 deficiency: a randomized, placebo-controlled trial (2006). https://pubmed.ncbi.nlm.nih.gov/16895884/ DOI: 10.1093/ajcn/84.2.361","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"73145023-2982-5848-aff2-8d8875d6b9c5","stable_key":"import-7fc92b9e-9cbf-556e-8719-6b5244625250","title":"Vitamin B12: mechanisms, deficiency and nutrient interactions (2026-09-17)","document_type":"imported_text","citation_label":"AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text.","file_path":"","sha256":"ad5b3a51d36e856aa7fdfd1cc23f690b094689bad87d28e1a621a54675a01c92","revision_id":"118bd616-0c13-549f-bfeb-bc439715b89c","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}