Component

Human erythrocyte ATP concentration

Human erythrocyte ATP concentration. Species, exposure and limitations are retained in each linked claim.

3 recorded relationships. Experimental role, claim status and evidence remain attached to each record.

Read recorded mechanisms Open recursive mind map

How nutrients influence it

Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.

How nutrients reach it in more than one step

Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.

Tracing routes…

What it does

Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.

Recorded relationships

What acts on it

  1. The postoperative and glucose-associated serum phosphate reductions were not accompanied by reduced red-cell ATP.

    Postoperative glucose-infusion regimens in the 1989 study → Human erythrocyte ATP concentration source_derived_draftungraded
    Experimental context and source evidence
    evidence_span
    {"source_cache": "artifacts/phosphorus-research/2741619.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "62051650a8db9312feacd99776a0a1bc2b55587b371ede554ae61fbdf335de30", "start_char": 0, "end_char": 1180, "text_sha256": "62051650a8db9312feacd99776a0a1bc2b55587b371ede554ae61fbdf335de30"}
    experimental_model
    Randomized postoperative glucose-infusion timing study
    exposure
    Equal daily glucose supplied continuously versus in five-hour infusions
    limitations
    Acute redistribution and postoperative hypophosphatemia are not synonymous with severe whole-body phosphate depletion.
    nutrient_topic
    Phosphorus research collection; topical membership is not evidence of a direct dietary effect. · Phosphorus
    organism
    Human
    plain_language
    Blood phosphate fell while the measured red-cell ATP pool remained preserved.
    primary_references
    [phosphorus-p2741619] Postoperative and glucose-induced hypophosphatemia in relation to adenosine triphosphate and 2,3-diphosphoglycerate in erythrocytes. (1989). https://pubmed.ncbi.nlm.nih.gov/2741619/
    tissue_or_cell_type
    Patients after elective colonic surgery; serum and red cells

    Phosphorus: metabolism, signaling and nutrient connections (2026-09-17) · lines 1128–1139

    AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Randomized postoperative glucose-infusion timing study · source_derived_draft · unverified_draft

    ### phosphorus-glucose-atp-null The postoperative and glucose-associated serum phosphate reductions were not accompanied by reduced red-cell ATP. Condition category: normal nutrient_topic: Phosphorus research collection; topical membership is not evidence of a direct dietary effect. plain_language: Blood phosphate fell while the measured red-cell ATP pool remained preserved. organism: Human tissue_or_cell_type: Patients after elective colonic surgery; serum and red cells experimental_model: Randomized postoperative glucose-infusion timing study limitations: Acute redistribution and postoperative hypophosphatemia are not synonymous with severe whole-body phosphate depletion. exposure: Equal daily glucose supplied continuously versus in five-hour infusions evidence_span: {"source_cache": "artifacts/phosphorus-research/2741619.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "62051650a8db9312feacd99776a0a1bc2b55587b371ede554ae61fbdf335de30", "start_char": 0, "end_char": 1180, "text_sha256": "62051650a8db9312feacd99776a0a1bc2b55587b371ede554ae61fbdf335de30"} [phosphorus-p2741619] Postoperative and glucose-induced hypophosphatemia in relation to adenosine triphosphate and 2,3-diphosphoglycerate in erythrocytes. (1989). https://pubmed.ncbi.nlm.nih.gov/2741619/
    Complete structured claim and evidence

  2. The 1-versus-5 mmol/L Pi incubation changed erythrocyte glycolytic output without a significant ATP-concentration change.

    Inorganic phosphate (Pi; protonation depends on pH) → Human erythrocyte ATP concentration source_derived_draftungraded
    Experimental context and source evidence
    evidence_span
    {"source_cache": "artifacts/phosphorus-research/4042545.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "474d2b2722565fa0e4c2f0ddf4a332715ce176f9325b9af5c22027bd6ac93e43", "start_char": 0, "end_char": 1711, "text_sha256": "474d2b2722565fa0e4c2f0ddf4a332715ce176f9325b9af5c22027bd6ac93e43"}
    experimental_model
    ICU erythrocyte measurements and normal-donor cell incubation
    exposure
    Plasma Pi 0.1–4.2 mmol/L in patients; normal-donor cells incubated at 1 or 5 mmol/L Pi
    limitations
    Observed ranges are not universal thresholds; ATP concentration, ATP synthetic flux and 2,3-DPG are separate endpoints.
    nutrient_topic
    Phosphorus research collection; topical membership is not evidence of a direct dietary effect. · Phosphorus
    organism
    Human
    plain_language
    A faster flux did not necessarily make the ATP pool larger.
    primary_references
    [phosphorus-p4042545] Phosphate metabolism in erythrocytes of critically ill patients. (1985). https://pubmed.ncbi.nlm.nih.gov/4042545/ DOI: 10.1042/cs0690435
    tissue_or_cell_type
    Red blood cells

    Phosphorus: metabolism, signaling and nutrient connections (2026-09-17) · lines 1102–1113

    AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · ICU erythrocyte measurements and normal-donor cell incubation · source_derived_draft · unverified_draft

    ### phosphorus-rbc-atp-buffered The 1-versus-5 mmol/L Pi incubation changed erythrocyte glycolytic output without a significant ATP-concentration change. Condition category: normal nutrient_topic: Phosphorus research collection; topical membership is not evidence of a direct dietary effect. plain_language: A faster flux did not necessarily make the ATP pool larger. organism: Human tissue_or_cell_type: Red blood cells experimental_model: ICU erythrocyte measurements and normal-donor cell incubation limitations: Observed ranges are not universal thresholds; ATP concentration, ATP synthetic flux and 2,3-DPG are separate endpoints. exposure: Plasma Pi 0.1–4.2 mmol/L in patients; normal-donor cells incubated at 1 or 5 mmol/L Pi evidence_span: {"source_cache": "artifacts/phosphorus-research/4042545.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "474d2b2722565fa0e4c2f0ddf4a332715ce176f9325b9af5c22027bd6ac93e43", "start_char": 0, "end_char": 1711, "text_sha256": "474d2b2722565fa0e4c2f0ddf4a332715ce176f9325b9af5c22027bd6ac93e43"} [phosphorus-p4042545] Phosphate metabolism in erythrocytes of critically ill patients. (1985). https://pubmed.ncbi.nlm.nih.gov/4042545/ DOI: 10.1042/cs0690435
    Complete structured claim and evidence

  3. Marked erythrocyte ATP depletion below 1 mmol/L cells was observed only when cellular Pi was below 0.3 mmol/L cells and plasma Pi below 0.35 mmol/L in this dataset.

    Plasma inorganic phosphate concentration → Human erythrocyte ATP concentration source_derived_draftungraded
    Experimental context and source evidence
    availability_state
    biomarker_context Imported condition classification; unverified.
    evidence_span
    {"source_cache": "artifacts/phosphorus-research/4042545.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "474d2b2722565fa0e4c2f0ddf4a332715ce176f9325b9af5c22027bd6ac93e43", "start_char": 0, "end_char": 1711, "text_sha256": "474d2b2722565fa0e4c2f0ddf4a332715ce176f9325b9af5c22027bd6ac93e43"}
    experimental_model
    ICU erythrocyte measurements and normal-donor cell incubation
    exposure
    Plasma Pi 0.1–4.2 mmol/L in patients; normal-donor cells incubated at 1 or 5 mmol/L Pi
    limitations
    Observed ranges are not universal thresholds; ATP concentration, ATP synthetic flux and 2,3-DPG are separate endpoints.
    nutrient_topic
    Phosphorus research collection; topical membership is not evidence of a direct dietary effect. · Phosphorus
    organism
    Human
    plain_language
    Severe phosphate depletion can accompany low red-cell ATP, but this study does not set a universal cutoff.
    primary_references
    [phosphorus-p4042545] Phosphate metabolism in erythrocytes of critically ill patients. (1985). https://pubmed.ncbi.nlm.nih.gov/4042545/ DOI: 10.1042/cs0690435
    tissue_or_cell_type
    Red blood cells
    trigger_kind
    biomarker_context Imported condition classification; unverified.

    Phosphorus: metabolism, signaling and nutrient connections (2026-09-17) · lines 1063–1074

    AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · ICU erythrocyte measurements and normal-donor cell incubation · source_derived_draft · unverified_draft

    ### phosphorus-rbc-atp-low Marked erythrocyte ATP depletion below 1 mmol/L cells was observed only when cellular Pi was below 0.3 mmol/L cells and plasma Pi below 0.35 mmol/L in this dataset. Condition category: biomarker_context nutrient_topic: Phosphorus research collection; topical membership is not evidence of a direct dietary effect. plain_language: Severe phosphate depletion can accompany low red-cell ATP, but this study does not set a universal cutoff. organism: Human tissue_or_cell_type: Red blood cells experimental_model: ICU erythrocyte measurements and normal-donor cell incubation limitations: Observed ranges are not universal thresholds; ATP concentration, ATP synthetic flux and 2,3-DPG are separate endpoints. exposure: Plasma Pi 0.1–4.2 mmol/L in patients; normal-donor cells incubated at 1 or 5 mmol/L Pi evidence_span: {"source_cache": "artifacts/phosphorus-research/4042545.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "474d2b2722565fa0e4c2f0ddf4a332715ce176f9325b9af5c22027bd6ac93e43", "start_char": 0, "end_char": 1711, "text_sha256": "474d2b2722565fa0e4c2f0ddf4a332715ce176f9325b9af5c22027bd6ac93e43"} [phosphorus-p4042545] Phosphate metabolism in erythrocytes of critically ill patients. (1985). https://pubmed.ncbi.nlm.nih.gov/4042545/ DOI: 10.1042/cs0690435
    Complete structured claim and evidence

In the sources

Preserved passages that mention this component, quoted exactly. Open one to read it in context.

    This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.

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