{"id":"f4502976-6b3f-5de9-8f72-4b05e9870456","stable_key":"fe6af7fc-7372-5c4f-9c2f-2bbf56695397:phosphorus-rbc-atp-low","predicate":"is_associated_with","statement":"Marked erythrocyte ATP depletion below 1 mmol/L cells was observed only when cellular Pi was below 0.3 mmol/L cells and plasma Pi below 0.35 mmol/L in this dataset.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"c9ace23e-f0cb-58d1-a173-fe9e2f40e2a8","mechanism_event_label":"Severe phosphate depletion can accompany low red-cell ATP, but this study does not set a universal cutoff.","subject":{"id":"53b78cfd-6503-5141-9601-91cef6108adc","slug":"plasma-inorganic-phosphate","display_name":"Plasma inorganic phosphate concentration","entity_type_key":"cellular_process"},"object":{"id":"9d275915-c548-50bc-886d-3940f1434a05","slug":"erythrocyte-atp-concentration","display_name":"Human erythrocyte ATP concentration","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"c9ace23e-f0cb-58d1-a173-fe9e2f40e2a8","stable_key":"fe6af7fc-7372-5c4f-9c2f-2bbf56695397:phosphorus-rbc-atp-low-event","event_type":"observed_intervention","label":"Severe phosphate depletion can accompany low red-cell ATP, but this study does not set a universal cutoff.","description":"Marked erythrocyte ATP depletion below 1 mmol/L cells was observed only when cellular Pi was below 0.3 mmol/L cells and plasma Pi below 0.35 mmol/L in this dataset.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"53b78cfd-6503-5141-9601-91cef6108adc","slug":"plasma-inorganic-phosphate","display_name":"Plasma inorganic phosphate concentration","entity_type_key":"cellular_process"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"9d275915-c548-50bc-886d-3940f1434a05","slug":"erythrocyte-atp-concentration","display_name":"Human erythrocyte ATP concentration","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""}]},"contexts":[{"dimension":"availability_state","value_text":"biomarker_context","comparator":null,"unit":null,"notes":"Imported condition classification; unverified.","entity":null},{"dimension":"evidence_span","value_text":"{\"source_cache\": \"artifacts/phosphorus-research/4042545.abstract.txt\", \"locator\": \"Primary indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"474d2b2722565fa0e4c2f0ddf4a332715ce176f9325b9af5c22027bd6ac93e43\", \"start_char\": 0, \"end_char\": 1711, \"text_sha256\": \"474d2b2722565fa0e4c2f0ddf4a332715ce176f9325b9af5c22027bd6ac93e43\"}","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"ICU erythrocyte measurements and normal-donor cell incubation","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure","value_text":"Plasma Pi 0.1–4.2 mmol/L in patients; normal-donor cells incubated at 1 or 5 mmol/L Pi","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Observed ranges are not universal thresholds; ATP concentration, ATP synthetic flux and 2,3-DPG are separate endpoints.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Phosphorus research collection; topical membership is not evidence of a direct dietary effect.","comparator":null,"unit":null,"notes":"","entity":{"slug":"phosphorus","display_name":"Phosphorus","entity_type_key":"nutrient_element"}},{"dimension":"organism","value_text":"Human","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"Severe phosphate depletion can accompany low red-cell ATP, but this study does not set a universal cutoff.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[phosphorus-p4042545] Phosphate metabolism in erythrocytes of critically ill patients. (1985). https://pubmed.ncbi.nlm.nih.gov/4042545/ DOI: 10.1042/cs0690435","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"Red blood cells","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"trigger_kind","value_text":"biomarker_context","comparator":null,"unit":null,"notes":"Imported condition classification; unverified.","entity":null}],"evidence":[{"id":"c2201773-499e-5898-94ec-94d5ea59ea1d","evidence_kind":"source_excerpt","locator":"Lines 1063-1074","start_line":1063,"end_line":1074,"excerpt":"### phosphorus-rbc-atp-low\nMarked erythrocyte ATP depletion below 1 mmol/L cells was observed only when cellular Pi was below 0.3 mmol/L cells and plasma Pi below 0.35 mmol/L in this dataset.\nCondition category: biomarker_context\nnutrient_topic: Phosphorus research collection; topical membership is not evidence of a direct dietary effect.\nplain_language: Severe phosphate depletion can accompany low red-cell ATP, but this study does not set a universal cutoff.\norganism: Human\ntissue_or_cell_type: Red blood cells\nexperimental_model: ICU erythrocyte measurements and normal-donor cell incubation\nlimitations: Observed ranges are not universal thresholds; ATP concentration, ATP synthetic flux and 2,3-DPG are separate endpoints.\nexposure: Plasma Pi 0.1–4.2 mmol/L in patients; normal-donor cells incubated at 1 or 5 mmol/L Pi\nevidence_span: {\"source_cache\": \"artifacts/phosphorus-research/4042545.abstract.txt\", \"locator\": \"Primary indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"474d2b2722565fa0e4c2f0ddf4a332715ce176f9325b9af5c22027bd6ac93e43\", \"start_char\": 0, \"end_char\": 1711, \"text_sha256\": \"474d2b2722565fa0e4c2f0ddf4a332715ce176f9325b9af5c22027bd6ac93e43\"}\n[phosphorus-p4042545] Phosphate metabolism in erythrocytes of critically ill patients. 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