{"id":"57af9161-ace8-5910-86a6-449697a404ea","stable_key":"fe6af7fc-7372-5c4f-9c2f-2bbf56695397:phosphorus-glucose-atp-null","predicate":"has_observed_effect","statement":"The postoperative and glucose-associated serum phosphate reductions were not accompanied by reduced red-cell ATP.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"neutral","is_public":true,"mechanism_event_id":"9d7662a3-be44-55b2-bdc9-c8824cb12150","mechanism_event_label":"Blood phosphate fell while the measured red-cell ATP pool remained preserved.","subject":{"id":"cafec04e-7604-553c-b21b-01f1c67fcb61","slug":"postoperative-glucose-infusion","display_name":"Postoperative glucose-infusion regimens in the 1989 study","entity_type_key":"chemical_species"},"object":{"id":"9d275915-c548-50bc-886d-3940f1434a05","slug":"erythrocyte-atp-concentration","display_name":"Human erythrocyte ATP concentration","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"9d7662a3-be44-55b2-bdc9-c8824cb12150","stable_key":"fe6af7fc-7372-5c4f-9c2f-2bbf56695397:phosphorus-glucose-atp-null-event","event_type":"observed_intervention","label":"Blood phosphate fell while the measured red-cell ATP pool remained preserved.","description":"The postoperative and glucose-associated serum phosphate reductions were not accompanied by reduced red-cell ATP.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"cafec04e-7604-553c-b21b-01f1c67fcb61","slug":"postoperative-glucose-infusion","display_name":"Postoperative glucose-infusion regimens in the 1989 study","entity_type_key":"chemical_species"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"9d275915-c548-50bc-886d-3940f1434a05","slug":"erythrocyte-atp-concentration","display_name":"Human erythrocyte ATP concentration","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""}]},"contexts":[{"dimension":"evidence_span","value_text":"{\"source_cache\": \"artifacts/phosphorus-research/2741619.abstract.txt\", \"locator\": \"Primary indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"62051650a8db9312feacd99776a0a1bc2b55587b371ede554ae61fbdf335de30\", \"start_char\": 0, \"end_char\": 1180, \"text_sha256\": \"62051650a8db9312feacd99776a0a1bc2b55587b371ede554ae61fbdf335de30\"}","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Randomized postoperative glucose-infusion timing study","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure","value_text":"Equal daily glucose supplied continuously versus in five-hour infusions","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Acute redistribution and postoperative hypophosphatemia are not synonymous with severe whole-body phosphate depletion.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Phosphorus research collection; topical membership is not evidence of a direct dietary effect.","comparator":null,"unit":null,"notes":"","entity":{"slug":"phosphorus","display_name":"Phosphorus","entity_type_key":"nutrient_element"}},{"dimension":"organism","value_text":"Human","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"Blood phosphate fell while the measured red-cell ATP pool remained preserved.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[phosphorus-p2741619] Postoperative and glucose-induced hypophosphatemia in relation to adenosine triphosphate and 2,3-diphosphoglycerate in erythrocytes. (1989). https://pubmed.ncbi.nlm.nih.gov/2741619/","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"Patients after elective colonic surgery; serum and red cells","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"af45daeb-999b-5456-ae01-419c0bb89c24","evidence_kind":"source_excerpt","locator":"Lines 1128-1139","start_line":1128,"end_line":1139,"excerpt":"### phosphorus-glucose-atp-null\nThe postoperative and glucose-associated serum phosphate reductions were not accompanied by reduced red-cell ATP.\nCondition category: normal\nnutrient_topic: Phosphorus research collection; topical membership is not evidence of a direct dietary effect.\nplain_language: Blood phosphate fell while the measured red-cell ATP pool remained preserved.\norganism: Human\ntissue_or_cell_type: Patients after elective colonic surgery; serum and red cells\nexperimental_model: Randomized postoperative glucose-infusion timing study\nlimitations: Acute redistribution and postoperative hypophosphatemia are not synonymous with severe whole-body phosphate depletion.\nexposure: Equal daily glucose supplied continuously versus in five-hour infusions\nevidence_span: {\"source_cache\": \"artifacts/phosphorus-research/2741619.abstract.txt\", \"locator\": \"Primary indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"62051650a8db9312feacd99776a0a1bc2b55587b371ede554ae61fbdf335de30\", \"start_char\": 0, \"end_char\": 1180, \"text_sha256\": \"62051650a8db9312feacd99776a0a1bc2b55587b371ede554ae61fbdf335de30\"}\n[phosphorus-p2741619] Postoperative and glucose-induced hypophosphatemia in relation to adenosine triphosphate and 2,3-diphosphoglycerate in erythrocytes. 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