Component
Plasma inorganic phosphate concentration
Plasma inorganic phosphate concentration. Species, exposure and limitations are retained in each linked claim.
1 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
What it acts on
Marked erythrocyte ATP depletion below 1 mmol/L cells was observed only when cellular Pi was below 0.3 mmol/L cells and plasma Pi below 0.35 mmol/L in this dataset.
Experimental context and source evidence
- availability_state
- biomarker_context Imported condition classification; unverified.
- evidence_span
- {"source_cache": "artifacts/phosphorus-research/4042545.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "474d2b2722565fa0e4c2f0ddf4a332715ce176f9325b9af5c22027bd6ac93e43", "start_char": 0, "end_char": 1711, "text_sha256": "474d2b2722565fa0e4c2f0ddf4a332715ce176f9325b9af5c22027bd6ac93e43"}
- experimental_model
- ICU erythrocyte measurements and normal-donor cell incubation
- exposure
- Plasma Pi 0.1–4.2 mmol/L in patients; normal-donor cells incubated at 1 or 5 mmol/L Pi
- limitations
- Observed ranges are not universal thresholds; ATP concentration, ATP synthetic flux and 2,3-DPG are separate endpoints.
- nutrient_topic
- Phosphorus research collection; topical membership is not evidence of a direct dietary effect. · Phosphorus
- organism
- Human
- plain_language
- Severe phosphate depletion can accompany low red-cell ATP, but this study does not set a universal cutoff.
- primary_references
- [phosphorus-p4042545] Phosphate metabolism in erythrocytes of critically ill patients. (1985). https://pubmed.ncbi.nlm.nih.gov/4042545/ DOI: 10.1042/cs0690435
- tissue_or_cell_type
- Red blood cells
- trigger_kind
- biomarker_context Imported condition classification; unverified.
Phosphorus: metabolism, signaling and nutrient connections (2026-09-17) · lines 1063–1074
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · ICU erythrocyte measurements and normal-donor cell incubation · source_derived_draft · unverified_draft
### phosphorus-rbc-atp-low Marked erythrocyte ATP depletion below 1 mmol/L cells was observed only when cellular Pi was below 0.3 mmol/L cells and plasma Pi below 0.35 mmol/L in this dataset. Condition category: biomarker_context nutrient_topic: Phosphorus research collection; topical membership is not evidence of a direct dietary effect. plain_language: Severe phosphate depletion can accompany low red-cell ATP, but this study does not set a universal cutoff. organism: Human tissue_or_cell_type: Red blood cells experimental_model: ICU erythrocyte measurements and normal-donor cell incubation limitations: Observed ranges are not universal thresholds; ATP concentration, ATP synthetic flux and 2,3-DPG are separate endpoints. exposure: Plasma Pi 0.1–4.2 mmol/L in patients; normal-donor cells incubated at 1 or 5 mmol/L Pi evidence_span: {"source_cache": "artifacts/phosphorus-research/4042545.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "474d2b2722565fa0e4c2f0ddf4a332715ce176f9325b9af5c22027bd6ac93e43", "start_char": 0, "end_char": 1711, "text_sha256": "474d2b2722565fa0e4c2f0ddf4a332715ce176f9325b9af5c22027bd6ac93e43"} [phosphorus-p4042545] Phosphate metabolism in erythrocytes of critically ill patients. (1985). https://pubmed.ncbi.nlm.nih.gov/4042545/ DOI: 10.1042/cs0690435
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.