Component
Dried-blood-spot thyroglobulin concentration
Dried-blood-spot thyroglobulin concentration. Study-specific scope and measurement methods are recorded with each claim.
2 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
What it acts on
The third and 97th percentiles of the standardized dried-blood-spot Tg assay were 4 and 40 micrograms/L in the 700 iodine-sufficient, euthyroid, anti-Tg-negative children.
Experimental context and source evidence
- availability_state
- biomarker_context Imported condition classification; unverified.
- cross_nutrient
- false
- evidence_location
- Primary indexed abstract.
- experimental_model
- Assay-standardization study in 700 iodine-sufficient euthyroid anti-Tg-antibody-negative children aged 5–14 and separate 10-month iodized-salt intervention
- exposure
- International reference sample and longitudinal measurements before, 5 months and 10 months after salt iodization in deficient children.
- limitations
- Assay-specific pediatric reference distribution; not a universal adult/pregnancy threshold. Anti-Tg-antibody-positive children were excluded from the reference sample; antibody interference and other thyroid diseases remain relevant.
- nutrient_topic
- Iodine research collection; topical membership is not evidence of a direct dietary effect. · Iodine
- organism
- Homo sapiens
- plain_language
- The study established a reference distribution for a particular pediatric assay.
- primary_references
- [iod-clin-tg2006] Assessment of iodine status using dried blood spot thyroglobulin: development of reference material and establishment of an international reference range in iodine-sufficient children. (2006). https://pubmed.ncbi.nlm.nih.gov/16968789/ DOI: 10.1210/jc.2006-1370
- tissue_or_cell_type
- Dried whole-blood thyroglobulin assay
- trigger_kind
- biomarker_context Imported condition classification; unverified.
Iodine: thyroid hormone production, deficiency, excess and nutrient interactions (2026-09-17) · lines 1594–1606
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Assay-standardization study in 700 iodine-sufficient euthyroid anti-Tg-antibody-negative children aged 5–14 and separate 10-month iodized-salt intervention · source_derived_draft · unverified_draft
### iod-clin-dbs-tg-reference The third and 97th percentiles of the standardized dried-blood-spot Tg assay were 4 and 40 micrograms/L in the 700 iodine-sufficient, euthyroid, anti-Tg-negative children. Condition category: biomarker_context nutrient_topic: Iodine research collection; topical membership is not evidence of a direct dietary effect. plain_language: The study established a reference distribution for a particular pediatric assay. organism: Homo sapiens tissue_or_cell_type: Dried whole-blood thyroglobulin assay experimental_model: Assay-standardization study in 700 iodine-sufficient euthyroid anti-Tg-antibody-negative children aged 5–14 and separate 10-month iodized-salt intervention limitations: Assay-specific pediatric reference distribution; not a universal adult/pregnancy threshold. Anti-Tg-antibody-positive children were excluded from the reference sample; antibody interference and other thyroid diseases remain relevant. exposure: International reference sample and longitudinal measurements before, 5 months and 10 months after salt iodization in deficient children. cross_nutrient: false evidence_location: Primary indexed abstract. [iod-clin-tg2006] Assessment of iodine status using dried blood spot thyroglobulin: development of reference material and establishment of an international reference range in iodine-sufficient children. (2006). https://pubmed.ncbi.nlm.nih.gov/16968789/ DOI: 10.1210/jc.2006-1370
Complete structured claim and evidence
What acts on it
Median dried-blood-spot thyroglobulin fell from 49 to 13 and 8 micrograms/L at 5 and 10 months after iodized salt introduction; proportions above 40 micrograms/L fell from over two thirds to 7% and 3%.
Experimental context and source evidence
- availability_state
- biomarker_context Imported condition classification; unverified.
- cross_nutrient
- false
- evidence_location
- Primary indexed abstract.
- experimental_model
- Assay-standardization study in 700 iodine-sufficient euthyroid anti-Tg-antibody-negative children aged 5–14 and separate 10-month iodized-salt intervention
- exposure
- International reference sample and longitudinal measurements before, 5 months and 10 months after salt iodization in deficient children.
- limitations
- Assay-specific pediatric reference distribution; not a universal adult/pregnancy threshold. Anti-Tg-antibody-positive children were excluded from the reference sample; antibody interference and other thyroid diseases remain relevant.
- nutrient_topic
- Iodine research collection; topical membership is not evidence of a direct dietary effect. · Iodine
- organism
- Homo sapiens
- plain_language
- This thyroglobulin assay tracked the population’s response to iodine repletion.
- primary_references
- [iod-clin-tg2006] Assessment of iodine status using dried blood spot thyroglobulin: development of reference material and establishment of an international reference range in iodine-sufficient children. (2006). https://pubmed.ncbi.nlm.nih.gov/16968789/ DOI: 10.1210/jc.2006-1370
- tissue_or_cell_type
- Dried whole-blood thyroglobulin assay
- trigger_kind
- biomarker_context Imported condition classification; unverified.
Iodine: thyroid hormone production, deficiency, excess and nutrient interactions (2026-09-17) · lines 1580–1592
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Assay-standardization study in 700 iodine-sufficient euthyroid anti-Tg-antibody-negative children aged 5–14 and separate 10-month iodized-salt intervention · source_derived_draft · unverified_draft
### iod-clin-dbs-tg-response Median dried-blood-spot thyroglobulin fell from 49 to 13 and 8 micrograms/L at 5 and 10 months after iodized salt introduction; proportions above 40 micrograms/L fell from over two thirds to 7% and 3%. Condition category: biomarker_context nutrient_topic: Iodine research collection; topical membership is not evidence of a direct dietary effect. plain_language: This thyroglobulin assay tracked the population’s response to iodine repletion. organism: Homo sapiens tissue_or_cell_type: Dried whole-blood thyroglobulin assay experimental_model: Assay-standardization study in 700 iodine-sufficient euthyroid anti-Tg-antibody-negative children aged 5–14 and separate 10-month iodized-salt intervention limitations: Assay-specific pediatric reference distribution; not a universal adult/pregnancy threshold. Anti-Tg-antibody-positive children were excluded from the reference sample; antibody interference and other thyroid diseases remain relevant. exposure: International reference sample and longitudinal measurements before, 5 months and 10 months after salt iodization in deficient children. cross_nutrient: false evidence_location: Primary indexed abstract. [iod-clin-tg2006] Assessment of iodine status using dried blood spot thyroglobulin: development of reference material and establishment of an international reference range in iodine-sufficient children. (2006). https://pubmed.ncbi.nlm.nih.gov/16968789/ DOI: 10.1210/jc.2006-1370
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.