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(2006). https://pubmed.ncbi.nlm.nih.gov/16968789/ DOI: 10.1210/jc.2006-1370","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"Dried whole-blood thyroglobulin assay","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"trigger_kind","value_text":"biomarker_context","comparator":null,"unit":null,"notes":"Imported condition classification; unverified.","entity":null}],"evidence":[{"id":"74000ee8-480c-5500-967b-9936b4ac518a","evidence_kind":"source_excerpt","locator":"Lines 1580-1592","start_line":1580,"end_line":1592,"excerpt":"### iod-clin-dbs-tg-response\nMedian dried-blood-spot thyroglobulin fell from 49 to 13 and 8 micrograms/L at 5 and 10 months after iodized salt introduction; proportions above 40 micrograms/L fell from over two thirds to 7% and 3%.\nCondition category: biomarker_context\nnutrient_topic: Iodine research collection; topical membership is not evidence of a direct dietary effect.\nplain_language: This thyroglobulin assay tracked the population’s response to iodine repletion.\norganism: Homo sapiens\ntissue_or_cell_type: Dried whole-blood thyroglobulin assay\nexperimental_model: Assay-standardization study in 700 iodine-sufficient euthyroid anti-Tg-antibody-negative children aged 5–14 and separate 10-month iodized-salt intervention\nlimitations: Assay-specific pediatric reference distribution; not a universal adult/pregnancy threshold. Anti-Tg-antibody-positive children were excluded from the reference sample; antibody interference and other thyroid diseases remain relevant.\nexposure: International reference sample and longitudinal measurements before, 5 months and 10 months after salt iodization in deficient children.\ncross_nutrient: false\nevidence_location: Primary indexed abstract.\n[iod-clin-tg2006] Assessment of iodine status using dried blood spot thyroglobulin: development of reference material and establishment of an international reference range in iodine-sufficient children. (2006). https://pubmed.ncbi.nlm.nih.gov/16968789/ DOI: 10.1210/jc.2006-1370","model_system":"Assay-standardization study in 700 iodine-sufficient euthyroid anti-Tg-antibody-negative children aged 5–14 and separate 10-month iodized-salt intervention","directness":"author_interpretation","verification_status":"source_derived_draft","notes":"Exact curation-document quotation, not publisher quotation. Study references: [iod-clin-tg2006] Assessment of iodine status using dried blood spot thyroglobulin: development of reference material and establishment of an international reference range in iodine-sufficient children. (2006). https://pubmed.ncbi.nlm.nih.gov/16968789/ DOI: 10.1210/jc.2006-1370","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"76da623d-a34a-5a5c-a942-d7571a85c486","stable_key":"import-aaa7baba-8689-56ab-ba1e-b71542bcb8e9","title":"Iodine: thyroid hormone production, deficiency, excess and nutrient interactions (2026-09-17)","document_type":"imported_text","citation_label":"AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. 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