Component
Human cytochrome P450 2B6 / CYP2B6
Human cytochrome P450 2B6 / CYP2B6. Species, exposure and limitations are retained in each linked claim.
2 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
What acts on it
CYP2B6 activity was inhibited by the mixture.
Experimental context and source evidence
- evidence_span
- {"source_cache": "artifacts/curcumin-research/18480186.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "c1155ca38a767b3c3fa7bd494d0ad5590eed70a47812b7a6f3d977b43aa8a922", "start_char": 0, "end_char": 1788, "text_sha256": "c1155ca38a767b3c3fa7bd494d0ad5590eed70a47812b7a6f3d977b43aa8a922"}
- experimental_model
- Human microsomal/cytosolic and recombinant enzyme inhibition assays
- exposure
- Curcuminoid mixture, purified curcuminoids and piperine; micromolar concentrations
- limitations
- In-vitro inhibition does not automatically predict human drug levels. Extract, isolated curcumin and piperine are separate interventions.
- nutrient_topic
- Curcumin research collection; topical membership is not evidence of a direct dietary effect. · Curcumin
- organism
- Human enzyme systems
- plain_language
- Another enzyme was affected in the test system.
- primary_references
- [curcumin-p18480186] Curcuminoids inhibit multiple human cytochromes P450, UDP-glucuronosyltransferase, and sulfotransferase enzymes, whereas piperine is a relatively selective CYP3A4 inhibitor. (2008). https://pubmed.ncbi.nlm.nih.gov/18480186/ DOI: 10.1124/dmd.108.020552
- tissue_or_cell_type
- Drug metabolism assays
Curcumin: metabolism, signaling and nutrient connections (2026-09-17) · lines 853–864
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Human microsomal/cytosolic and recombinant enzyme inhibition assays · source_derived_draft · unverified_draft
### curcumin-extract-cyp2b6 CYP2B6 activity was inhibited by the mixture. Condition category: normal nutrient_topic: Curcumin research collection; topical membership is not evidence of a direct dietary effect. plain_language: Another enzyme was affected in the test system. organism: Human enzyme systems tissue_or_cell_type: Drug metabolism assays experimental_model: Human microsomal/cytosolic and recombinant enzyme inhibition assays limitations: In-vitro inhibition does not automatically predict human drug levels. Extract, isolated curcumin and piperine are separate interventions. exposure: Curcuminoid mixture, purified curcuminoids and piperine; micromolar concentrations evidence_span: {"source_cache": "artifacts/curcumin-research/18480186.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "c1155ca38a767b3c3fa7bd494d0ad5590eed70a47812b7a6f3d977b43aa8a922", "start_char": 0, "end_char": 1788, "text_sha256": "c1155ca38a767b3c3fa7bd494d0ad5590eed70a47812b7a6f3d977b43aa8a922"} [curcumin-p18480186] Curcuminoids inhibit multiple human cytochromes P450, UDP-glucuronosyltransferase, and sulfotransferase enzymes, whereas piperine is a relatively selective CYP3A4 inhibitor. (2008). https://pubmed.ncbi.nlm.nih.gov/18480186/ DOI: 10.1124/dmd.108.020552
Complete structured claim and evidence
Where it participates (unsigned role)
Astaxanthin induced CYP3A4 and CYP2B6 in cultured primary human hepatocytes, without the CYP1A/CYP2C induction reported in rat comparisons.
Experimental context and source evidence
- evidence_access
- Primary abstract
- experimental_model
- Primary human hepatocyte exposure experiment.
- limitations
- Cell induction is not a demonstrated clinical drug interaction; no automatic prediction of drug clearance or dose adjustment.
- nutrient_topic
- Astaxanthin collection; molecular form, preparation, species, exposure and manipulation remain explicit. · Astaxanthin
- plain_language
- Human liver cells showed a selective enzyme response.
- primary_references
- Metabolism and CYP-inducer properties of astaxanthin in man and primary human hepatocytes. · 2002 · https://pubmed.ncbi.nlm.nih.gov/11876499/ · DOI 10.1007/s00204-001-0287-5
Astaxanthin: transport, membrane chemistry, signaling and nutrient interactions (2026-09-19) · lines 134–140
AI-assisted research curation; primary-abstract references and experimental limitations individually identified. Not publisher full text. · supports · Primary human hepatocyte exposure experiment. · source_derived_draft · unverified_draft
## astaxanthin-cyp-induction Human liver cells showed a selective enzyme response. Astaxanthin induced CYP3A4 and CYP2B6 in cultured primary human hepatocytes, without the CYP1A/CYP2C induction reported in rat comparisons. Model: Primary human hepatocyte exposure experiment. Limitations: Cell induction is not a demonstrated clinical drug interaction; no automatic prediction of drug clearance or dose adjustment. Evidence access: Primary abstract Metabolism and CYP-inducer properties of astaxanthin in man and primary human hepatocytes. · 2002 · https://pubmed.ncbi.nlm.nih.gov/11876499/ · DOI 10.1007/s00204-001-0287-5
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.