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Extract, isolated curcumin and piperine are separate interventions.\nexposure: Curcuminoid mixture, purified curcuminoids and piperine; micromolar concentrations\nevidence_span: {\"source_cache\": \"artifacts/curcumin-research/18480186.abstract.txt\", \"locator\": \"Primary indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"c1155ca38a767b3c3fa7bd494d0ad5590eed70a47812b7a6f3d977b43aa8a922\", \"start_char\": 0, \"end_char\": 1788, \"text_sha256\": \"c1155ca38a767b3c3fa7bd494d0ad5590eed70a47812b7a6f3d977b43aa8a922\"}\n[curcumin-p18480186] Curcuminoids inhibit multiple human cytochromes P450, UDP-glucuronosyltransferase, and sulfotransferase enzymes, whereas piperine is a relatively selective CYP3A4 inhibitor. 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