Component

Curcuminoid extract, study-specific composition

Curcuminoid extract, study-specific composition. Species, exposure and limitations are retained in each linked claim.

4 recorded relationships. Experimental role, claim status and evidence remain attached to each record.

Read recorded mechanisms Open recursive mind map

How nutrients influence it

Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.

How nutrients reach it in more than one step

Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.

Tracing routes…

What it does

Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.

Recorded relationships

What it acts on

  1. Diabetes was diagnosed in 16.4% of placebo participants and none in the extract group during the nine-month trial.

    Curcuminoid extract, study-specific composition → Progression to type 2 diabetes in the specified trial source_derived_draftungraded
    Experimental context and source evidence
    evidence_span
    {"source_cache": "artifacts/curcumin-research/22773702.fulltext.txt", "locator": "Primary full-text span; zero-based, end-exclusive Unicode character offsets", "file_sha256": "d2f1991f0e993327d17999b977037bc985b6363b19cac0819f626ff39fc20b2c", "start_char": 2610, "end_char": 16568, "text_sha256": "1cb18c4ac70a894bf05fa5f70d42ba42348292e3b13d1e9e3d33c503d143bd98"}
    experimental_model
    Randomized double-blind placebo-controlled trial in 240 adults with prediabetes
    exposure
    Curcuminoid extract for nine months; 1500 mg/day curcuminoids in the full methods
    limitations
    Single trial in a selected population; no general guarantee of prevention or identified molecular mediator. This is an extract, not a purified-compound experiment.
    nutrient_topic
    Curcumin research collection; topical membership is not evidence of a direct dietary effect. · Curcumin
    organism
    Homo sapiens
    plain_language
    This trial found fewer new diabetes diagnoses in its treatment group.
    primary_references
    [curcumin-p22773702] Curcumin extract for prevention of type 2 diabetes. (2012). https://pubmed.ncbi.nlm.nih.gov/22773702/ DOI: 10.2337/dc12-0116
    tissue_or_cell_type
    Progression to diabetes and metabolic markers

    Curcumin: metabolism, signaling and nutrient connections (2026-09-17) · lines 1022–1033

    AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Randomized double-blind placebo-controlled trial in 240 adults with prediabetes · source_derived_draft · unverified_draft

    ### curcumin-diabetes-trial Diabetes was diagnosed in 16.4% of placebo participants and none in the extract group during the nine-month trial. Condition category: normal nutrient_topic: Curcumin research collection; topical membership is not evidence of a direct dietary effect. plain_language: This trial found fewer new diabetes diagnoses in its treatment group. organism: Homo sapiens tissue_or_cell_type: Progression to diabetes and metabolic markers experimental_model: Randomized double-blind placebo-controlled trial in 240 adults with prediabetes limitations: Single trial in a selected population; no general guarantee of prevention or identified molecular mediator. This is an extract, not a purified-compound experiment. exposure: Curcuminoid extract for nine months; 1500 mg/day curcuminoids in the full methods evidence_span: {"source_cache": "artifacts/curcumin-research/22773702.fulltext.txt", "locator": "Primary full-text span; zero-based, end-exclusive Unicode character offsets", "file_sha256": "d2f1991f0e993327d17999b977037bc985b6363b19cac0819f626ff39fc20b2c", "start_char": 2610, "end_char": 16568, "text_sha256": "1cb18c4ac70a894bf05fa5f70d42ba42348292e3b13d1e9e3d33c503d143bd98"} [curcumin-p22773702] Curcumin extract for prevention of type 2 diabetes. (2012). https://pubmed.ncbi.nlm.nih.gov/22773702/ DOI: 10.2337/dc12-0116
    Complete structured claim and evidence

  2. CYP2B6 activity was inhibited by the mixture.

    Curcuminoid extract, study-specific composition → Human cytochrome P450 2B6 / CYP2B6 source_derived_draftungraded
    Experimental context and source evidence
    evidence_span
    {"source_cache": "artifacts/curcumin-research/18480186.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "c1155ca38a767b3c3fa7bd494d0ad5590eed70a47812b7a6f3d977b43aa8a922", "start_char": 0, "end_char": 1788, "text_sha256": "c1155ca38a767b3c3fa7bd494d0ad5590eed70a47812b7a6f3d977b43aa8a922"}
    experimental_model
    Human microsomal/cytosolic and recombinant enzyme inhibition assays
    exposure
    Curcuminoid mixture, purified curcuminoids and piperine; micromolar concentrations
    limitations
    In-vitro inhibition does not automatically predict human drug levels. Extract, isolated curcumin and piperine are separate interventions.
    nutrient_topic
    Curcumin research collection; topical membership is not evidence of a direct dietary effect. · Curcumin
    organism
    Human enzyme systems
    plain_language
    Another enzyme was affected in the test system.
    primary_references
    [curcumin-p18480186] Curcuminoids inhibit multiple human cytochromes P450, UDP-glucuronosyltransferase, and sulfotransferase enzymes, whereas piperine is a relatively selective CYP3A4 inhibitor. (2008). https://pubmed.ncbi.nlm.nih.gov/18480186/ DOI: 10.1124/dmd.108.020552
    tissue_or_cell_type
    Drug metabolism assays

    Curcumin: metabolism, signaling and nutrient connections (2026-09-17) · lines 853–864

    AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Human microsomal/cytosolic and recombinant enzyme inhibition assays · source_derived_draft · unverified_draft

    ### curcumin-extract-cyp2b6 CYP2B6 activity was inhibited by the mixture. Condition category: normal nutrient_topic: Curcumin research collection; topical membership is not evidence of a direct dietary effect. plain_language: Another enzyme was affected in the test system. organism: Human enzyme systems tissue_or_cell_type: Drug metabolism assays experimental_model: Human microsomal/cytosolic and recombinant enzyme inhibition assays limitations: In-vitro inhibition does not automatically predict human drug levels. Extract, isolated curcumin and piperine are separate interventions. exposure: Curcuminoid mixture, purified curcuminoids and piperine; micromolar concentrations evidence_span: {"source_cache": "artifacts/curcumin-research/18480186.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "c1155ca38a767b3c3fa7bd494d0ad5590eed70a47812b7a6f3d977b43aa8a922", "start_char": 0, "end_char": 1788, "text_sha256": "c1155ca38a767b3c3fa7bd494d0ad5590eed70a47812b7a6f3d977b43aa8a922"} [curcumin-p18480186] Curcuminoids inhibit multiple human cytochromes P450, UDP-glucuronosyltransferase, and sulfotransferase enzymes, whereas piperine is a relatively selective CYP3A4 inhibitor. (2008). https://pubmed.ncbi.nlm.nih.gov/18480186/ DOI: 10.1124/dmd.108.020552
    Complete structured claim and evidence

  3. The mixture inhibited CYP2C19 with mixed inhibition kinetics.

    Curcuminoid extract, study-specific composition → Human cytochrome P450 2C19 source_derived_draftungraded
    Experimental context and source evidence
    evidence_span
    {"source_cache": "artifacts/curcumin-research/18480186.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "c1155ca38a767b3c3fa7bd494d0ad5590eed70a47812b7a6f3d977b43aa8a922", "start_char": 0, "end_char": 1788, "text_sha256": "c1155ca38a767b3c3fa7bd494d0ad5590eed70a47812b7a6f3d977b43aa8a922"}
    experimental_model
    Human microsomal/cytosolic and recombinant enzyme inhibition assays
    exposure
    Curcuminoid mixture, purified curcuminoids and piperine; micromolar concentrations
    limitations
    In-vitro inhibition does not automatically predict human drug levels. Extract, isolated curcumin and piperine are separate interventions.
    nutrient_topic
    Curcumin research collection; topical membership is not evidence of a direct dietary effect. · Curcumin
    organism
    Human enzyme systems
    plain_language
    The extract inhibited one drug-metabolizing enzyme in vitro.
    primary_references
    [curcumin-p18480186] Curcuminoids inhibit multiple human cytochromes P450, UDP-glucuronosyltransferase, and sulfotransferase enzymes, whereas piperine is a relatively selective CYP3A4 inhibitor. (2008). https://pubmed.ncbi.nlm.nih.gov/18480186/ DOI: 10.1124/dmd.108.020552
    tissue_or_cell_type
    Drug metabolism assays

    Curcumin: metabolism, signaling and nutrient connections (2026-09-17) · lines 840–851

    AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Human microsomal/cytosolic and recombinant enzyme inhibition assays · source_derived_draft · unverified_draft

    ### curcumin-extract-cyp2c19 The mixture inhibited CYP2C19 with mixed inhibition kinetics. Condition category: normal nutrient_topic: Curcumin research collection; topical membership is not evidence of a direct dietary effect. plain_language: The extract inhibited one drug-metabolizing enzyme in vitro. organism: Human enzyme systems tissue_or_cell_type: Drug metabolism assays experimental_model: Human microsomal/cytosolic and recombinant enzyme inhibition assays limitations: In-vitro inhibition does not automatically predict human drug levels. Extract, isolated curcumin and piperine are separate interventions. exposure: Curcuminoid mixture, purified curcuminoids and piperine; micromolar concentrations evidence_span: {"source_cache": "artifacts/curcumin-research/18480186.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "c1155ca38a767b3c3fa7bd494d0ad5590eed70a47812b7a6f3d977b43aa8a922", "start_char": 0, "end_char": 1788, "text_sha256": "c1155ca38a767b3c3fa7bd494d0ad5590eed70a47812b7a6f3d977b43aa8a922"} [curcumin-p18480186] Curcuminoids inhibit multiple human cytochromes P450, UDP-glucuronosyltransferase, and sulfotransferase enzymes, whereas piperine is a relatively selective CYP3A4 inhibitor. (2008). https://pubmed.ncbi.nlm.nih.gov/18480186/ DOI: 10.1124/dmd.108.020552
    Complete structured claim and evidence

  4. The mixture inhibited CYP2C9; purified curcumin was less potent than demethoxycurcumin against this activity.

    Curcuminoid extract, study-specific composition → Human cytochrome P450 2C9 source_derived_draftungraded
    Experimental context and source evidence
    evidence_span
    {"source_cache": "artifacts/curcumin-research/18480186.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "c1155ca38a767b3c3fa7bd494d0ad5590eed70a47812b7a6f3d977b43aa8a922", "start_char": 0, "end_char": 1788, "text_sha256": "c1155ca38a767b3c3fa7bd494d0ad5590eed70a47812b7a6f3d977b43aa8a922"}
    experimental_model
    Human microsomal/cytosolic and recombinant enzyme inhibition assays
    exposure
    Curcuminoid mixture, purified curcuminoids and piperine; micromolar concentrations
    limitations
    In-vitro inhibition does not automatically predict human drug levels. Extract, isolated curcumin and piperine are separate interventions.
    nutrient_topic
    Curcumin research collection; topical membership is not evidence of a direct dietary effect. · Curcumin
    organism
    Human enzyme systems
    plain_language
    Related curcuminoids did not have identical effects.
    primary_references
    [curcumin-p18480186] Curcuminoids inhibit multiple human cytochromes P450, UDP-glucuronosyltransferase, and sulfotransferase enzymes, whereas piperine is a relatively selective CYP3A4 inhibitor. (2008). https://pubmed.ncbi.nlm.nih.gov/18480186/ DOI: 10.1124/dmd.108.020552
    tissue_or_cell_type
    Drug metabolism assays

    Curcumin: metabolism, signaling and nutrient connections (2026-09-17) · lines 866–877

    AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Human microsomal/cytosolic and recombinant enzyme inhibition assays · source_derived_draft · unverified_draft

    ### curcumin-extract-cyp2c9 The mixture inhibited CYP2C9; purified curcumin was less potent than demethoxycurcumin against this activity. Condition category: normal nutrient_topic: Curcumin research collection; topical membership is not evidence of a direct dietary effect. plain_language: Related curcuminoids did not have identical effects. organism: Human enzyme systems tissue_or_cell_type: Drug metabolism assays experimental_model: Human microsomal/cytosolic and recombinant enzyme inhibition assays limitations: In-vitro inhibition does not automatically predict human drug levels. Extract, isolated curcumin and piperine are separate interventions. exposure: Curcuminoid mixture, purified curcuminoids and piperine; micromolar concentrations evidence_span: {"source_cache": "artifacts/curcumin-research/18480186.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "c1155ca38a767b3c3fa7bd494d0ad5590eed70a47812b7a6f3d977b43aa8a922", "start_char": 0, "end_char": 1788, "text_sha256": "c1155ca38a767b3c3fa7bd494d0ad5590eed70a47812b7a6f3d977b43aa8a922"} [curcumin-p18480186] Curcuminoids inhibit multiple human cytochromes P450, UDP-glucuronosyltransferase, and sulfotransferase enzymes, whereas piperine is a relatively selective CYP3A4 inhibitor. (2008). https://pubmed.ncbi.nlm.nih.gov/18480186/ DOI: 10.1124/dmd.108.020552
    Complete structured claim and evidence

In the sources

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    This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.

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