Component

Measured human circulating curcumin exposure, analytical fraction specified

Measured human circulating curcumin exposure, analytical fraction specified. Species, exposure and limitations are retained in each linked claim.

2 recorded relationships. Experimental role, claim status and evidence remain attached to each record.

Read recorded mechanisms Open recursive mind map

How nutrients influence it

Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.

How nutrients reach it in more than one step

Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.

Tracing routes…

What it does

Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.

Recorded relationships

What acts on it

  1. Adding piperine increased measured curcumin exposure in this human comparison; the study reported a 2000% bioavailability increase.

    Piperine → Measured human circulating curcumin exposure, analytical fraction specified source_derived_draftungraded
    Experimental context and source evidence
    evidence_span
    {"source_cache": "artifacts/curcumin-research/9619120.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "e0eb4e2d68139e3b863853c46e30e52ad3bd67eaed1e6c4bbdefb278af10ee0b", "start_char": 0, "end_char": 1316, "text_sha256": "e0eb4e2d68139e3b863853c46e30e52ad3bd67eaed1e6c4bbdefb278af10ee0b"}
    experimental_model
    Human single-dose pharmacokinetic comparison; separate rat experiments
    exposure
    2 g curcumin with or without 20 mg piperine
    limitations
    Small older formulation-specific experiment. The reported 2000% increase is not a universal multiplier, therapeutic benefit or proof of long-term safety.
    nutrient_topic
    Curcumin research collection; topical membership is not evidence of a direct dietary effect. · Curcumin
    organism
    Homo sapiens for the recorded claim
    plain_language
    Piperine changed exposure in this particular experiment.
    primary_references
    [curcumin-p9619120] Influence of piperine on the pharmacokinetics of curcumin in animals and human volunteers. (1998). https://pubmed.ncbi.nlm.nih.gov/9619120/ DOI: 10.1055/s-2006-957450
    tissue_or_cell_type
    Serum

    Curcumin: metabolism, signaling and nutrient connections (2026-09-17) · lines 268–279

    AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Human single-dose pharmacokinetic comparison; separate rat experiments · source_derived_draft · unverified_draft

    ### curcumin-piperine-exposure Adding piperine increased measured curcumin exposure in this human comparison; the study reported a 2000% bioavailability increase. Condition category: normal nutrient_topic: Curcumin research collection; topical membership is not evidence of a direct dietary effect. plain_language: Piperine changed exposure in this particular experiment. organism: Homo sapiens for the recorded claim tissue_or_cell_type: Serum experimental_model: Human single-dose pharmacokinetic comparison; separate rat experiments limitations: Small older formulation-specific experiment. The reported 2000% increase is not a universal multiplier, therapeutic benefit or proof of long-term safety. exposure: 2 g curcumin with or without 20 mg piperine evidence_span: {"source_cache": "artifacts/curcumin-research/9619120.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "e0eb4e2d68139e3b863853c46e30e52ad3bd67eaed1e6c4bbdefb278af10ee0b", "start_char": 0, "end_char": 1316, "text_sha256": "e0eb4e2d68139e3b863853c46e30e52ad3bd67eaed1e6c4bbdefb278af10ee0b"} [curcumin-p9619120] Influence of piperine on the pharmacokinetics of curcumin in animals and human volunteers. (1998). https://pubmed.ncbi.nlm.nih.gov/9619120/ DOI: 10.1055/s-2006-957450
    Complete structured claim and evidence

  2. Only one participant had detectable free curcumin at the assayed time points.

    Curcumin → Measured human circulating curcumin exposure, analytical fraction specified source_derived_draftungraded
    Experimental context and source evidence
    evidence_span
    {"source_cache": "artifacts/curcumin-research/18559556.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "1170d8765efee654882cc57cb7c4cf5f48bb4cb79fe5426a679f5bc27e886ee1", "start_char": 0, "end_char": 1500, "text_sha256": "1170d8765efee654882cc57cb7c4cf5f48bb4cb79fe5426a679f5bc27e886ee1"}
    experimental_model
    Single-dose pharmacokinetics in healthy volunteers
    exposure
    10- or 12-g oral preparation; sampling through 72 hours; free-curcumin detection limit 50 ng/mL
    limitations
    High historical experimental doses; a conjugate measurement must not be relabeled free curcumin.
    nutrient_topic
    Curcumin research collection; topical membership is not evidence of a direct dietary effect. · Curcumin
    organism
    Homo sapiens
    plain_language
    A large oral dose did not generally produce detectable free curcumin with this assay.
    primary_references
    [curcumin-p18559556] Pharmacokinetics of curcumin conjugate metabolites in healthy human subjects. (2008). https://pubmed.ncbi.nlm.nih.gov/18559556/ DOI: 10.1158/1055-9965.epi-07-2693
    tissue_or_cell_type
    Plasma

    Curcumin: metabolism, signaling and nutrient connections (2026-09-17) · lines 242–253

    AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Single-dose pharmacokinetics in healthy volunteers · source_derived_draft · unverified_draft

    ### curcumin-pk-free-low Only one participant had detectable free curcumin at the assayed time points. Condition category: normal nutrient_topic: Curcumin research collection; topical membership is not evidence of a direct dietary effect. plain_language: A large oral dose did not generally produce detectable free curcumin with this assay. organism: Homo sapiens tissue_or_cell_type: Plasma experimental_model: Single-dose pharmacokinetics in healthy volunteers limitations: High historical experimental doses; a conjugate measurement must not be relabeled free curcumin. exposure: 10- or 12-g oral preparation; sampling through 72 hours; free-curcumin detection limit 50 ng/mL evidence_span: {"source_cache": "artifacts/curcumin-research/18559556.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "1170d8765efee654882cc57cb7c4cf5f48bb4cb79fe5426a679f5bc27e886ee1", "start_char": 0, "end_char": 1500, "text_sha256": "1170d8765efee654882cc57cb7c4cf5f48bb4cb79fe5426a679f5bc27e886ee1"} [curcumin-p18559556] Pharmacokinetics of curcumin conjugate metabolites in healthy human subjects. (2008). https://pubmed.ncbi.nlm.nih.gov/18559556/ DOI: 10.1158/1055-9965.epi-07-2693
    Complete structured claim and evidence

In the sources

Preserved passages that mention this component, quoted exactly. Open one to read it in context.

    This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.

    Evidence, AI assistance and curation standards