{"id":"721244ed-5ccb-5f3d-a7aa-43e3527e140d","stable_key":"53d9b98d-e3a0-5416-bc88-adbe42a8cb1b:curcumin-pk-free-low","predicate":"shows_low_measured","statement":"Only one participant had detectable free curcumin at the assayed time points.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"7ae0539d-2a04-5da6-964f-2d7abe18a1bf","mechanism_event_label":"A large oral dose did not generally produce detectable free curcumin with this assay.","subject":{"id":"0e625439-d093-5d1b-8713-dcfdafcf6811","slug":"curcumin","display_name":"Curcumin","entity_type_key":"small_molecule"},"object":{"id":"3ed9f7c1-3d2d-5430-8532-a1ac06666a4e","slug":"curcumin-plasma-exposure","display_name":"Measured human circulating curcumin exposure, analytical fraction specified","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"7ae0539d-2a04-5da6-964f-2d7abe18a1bf","stable_key":"53d9b98d-e3a0-5416-bc88-adbe42a8cb1b:curcumin-pk-free-low-event","event_type":"observed_intervention","label":"A large oral dose did not generally produce detectable free curcumin with this assay.","description":"Only one participant had detectable free curcumin at the assayed time points.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"ff6d7228-be20-5ac6-9ad5-5d07d41f6644","slug":"curcumin-glucuronide","display_name":"Curcumin glucuronide","entity_type_key":"small_molecule"},"role":"measured_conjugate","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"9478dcfc-a771-5e31-8203-ded1b0fbd447","slug":"curcumin-sulfate","display_name":"Curcumin sulfate","entity_type_key":"small_molecule"},"role":"measured_conjugate","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"0e625439-d093-5d1b-8713-dcfdafcf6811","slug":"curcumin","display_name":"Curcumin","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""},{"entity":{"id":"3ed9f7c1-3d2d-5430-8532-a1ac06666a4e","slug":"curcumin-plasma-exposure","display_name":"Measured human circulating curcumin exposure, analytical fraction specified","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":3,"notes":""}]},"contexts":[{"dimension":"evidence_span","value_text":"{\"source_cache\": \"artifacts/curcumin-research/18559556.abstract.txt\", \"locator\": \"Primary indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"1170d8765efee654882cc57cb7c4cf5f48bb4cb79fe5426a679f5bc27e886ee1\", \"start_char\": 0, \"end_char\": 1500, \"text_sha256\": \"1170d8765efee654882cc57cb7c4cf5f48bb4cb79fe5426a679f5bc27e886ee1\"}","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Single-dose pharmacokinetics in healthy volunteers","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure","value_text":"10- or 12-g oral preparation; sampling through 72 hours; free-curcumin detection limit 50 ng/mL","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"High historical experimental doses; a conjugate measurement must not be relabeled free curcumin.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Curcumin research collection; topical membership is not evidence of a direct dietary effect.","comparator":null,"unit":null,"notes":"","entity":{"slug":"curcumin","display_name":"Curcumin","entity_type_key":"small_molecule"}},{"dimension":"organism","value_text":"Homo sapiens","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"A large oral dose did not generally produce detectable free curcumin with this assay.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[curcumin-p18559556] Pharmacokinetics of curcumin conjugate metabolites in healthy human subjects. (2008). https://pubmed.ncbi.nlm.nih.gov/18559556/ DOI: 10.1158/1055-9965.epi-07-2693","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"Plasma","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"104ee457-2fe5-5094-be9a-3e4caa974c37","evidence_kind":"source_excerpt","locator":"Lines 242-253","start_line":242,"end_line":253,"excerpt":"### curcumin-pk-free-low\nOnly one participant had detectable free curcumin at the assayed time points.\nCondition category: normal\nnutrient_topic: Curcumin research collection; topical membership is not evidence of a direct dietary effect.\nplain_language: A large oral dose did not generally produce detectable free curcumin with this assay.\norganism: Homo sapiens\ntissue_or_cell_type: Plasma\nexperimental_model: Single-dose pharmacokinetics in healthy volunteers\nlimitations: High historical experimental doses; a conjugate measurement must not be relabeled free curcumin.\nexposure: 10- or 12-g oral preparation; sampling through 72 hours; free-curcumin detection limit 50 ng/mL\nevidence_span: {\"source_cache\": \"artifacts/curcumin-research/18559556.abstract.txt\", \"locator\": \"Primary indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"1170d8765efee654882cc57cb7c4cf5f48bb4cb79fe5426a679f5bc27e886ee1\", \"start_char\": 0, \"end_char\": 1500, \"text_sha256\": \"1170d8765efee654882cc57cb7c4cf5f48bb4cb79fe5426a679f5bc27e886ee1\"}\n[curcumin-p18559556] Pharmacokinetics of curcumin conjugate metabolites in healthy human subjects. 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