Component

Human circulating curcumin conjugate exposure

Human circulating curcumin conjugate exposure. Species, exposure and limitations are retained in each linked claim.

3 recorded relationships. Experimental role, claim status and evidence remain attached to each record.

Read recorded mechanisms Open recursive mind map

How nutrients influence it

Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.

How nutrients reach it in more than one step

Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.

Tracing routes…

What it does

Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.

Recorded relationships

What acts on it

  1. The gamma-cyclodextrin preparation increased plasma AUC 30-fold relative to native curcumin.

    Gamma-cyclodextrin curcumin formulation → Human circulating curcumin conjugate exposure source_derived_draftungraded
    Experimental context and source evidence
    evidence_span
    {"source_cache": "artifacts/curcumin-research/34665507.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "19c566913aafc2ec8b5ac2d7053d7a94096ab234f4e5179af18eb1cdeeef5a2c", "start_char": 0, "end_char": 1481, "text_sha256": "19c566913aafc2ec8b5ac2d7053d7a94096ab234f4e5179af18eb1cdeeef5a2c"}
    experimental_model
    Randomized crossover pharmacokinetics plus simulated digestion
    exposure
    207 mg curcumin from eight preparations; 24-hour sampling
    limitations
    Measured circulating material was conjugated, with no free curcumin detected. Formulation exposure is not a clinical efficacy endpoint.
    nutrient_topic
    Curcumin research collection; topical membership is not evidence of a direct dietary effect. · Curcumin
    organism
    Twelve healthy adults; in-vitro digestion separately scoped
    plain_language
    A different delivery system also changed exposure.
    primary_references
    [curcumin-p34665507] Increasing Post-Digestive Solubility of Curcumin Is the Most Successful Strategy to Improve its Oral Bioavailability: A Randomized Cross-Over Trial in Healthy Adults and In Vitro Bioaccessibility Experiments. (2021). https://pubmed.ncbi.nlm.nih.gov/34665507/ DOI: 10.1002/mnfr.202100613
    tissue_or_cell_type
    Plasma and digestive test system

    Curcumin: metabolism, signaling and nutrient connections (2026-09-17) · lines 294–305

    AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Randomized crossover pharmacokinetics plus simulated digestion · source_derived_draft · unverified_draft

    ### curcumin-cyclodextrin-exposure The gamma-cyclodextrin preparation increased plasma AUC 30-fold relative to native curcumin. Condition category: normal nutrient_topic: Curcumin research collection; topical membership is not evidence of a direct dietary effect. plain_language: A different delivery system also changed exposure. organism: Twelve healthy adults; in-vitro digestion separately scoped tissue_or_cell_type: Plasma and digestive test system experimental_model: Randomized crossover pharmacokinetics plus simulated digestion limitations: Measured circulating material was conjugated, with no free curcumin detected. Formulation exposure is not a clinical efficacy endpoint. exposure: 207 mg curcumin from eight preparations; 24-hour sampling evidence_span: {"source_cache": "artifacts/curcumin-research/34665507.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "19c566913aafc2ec8b5ac2d7053d7a94096ab234f4e5179af18eb1cdeeef5a2c", "start_char": 0, "end_char": 1481, "text_sha256": "19c566913aafc2ec8b5ac2d7053d7a94096ab234f4e5179af18eb1cdeeef5a2c"} [curcumin-p34665507] Increasing Post-Digestive Solubility of Curcumin Is the Most Successful Strategy to Improve its Oral Bioavailability: A Randomized Cross-Over Trial in Healthy Adults and In Vitro Bioaccessibility Experiments. (2021). https://pubmed.ncbi.nlm.nih.gov/34665507/ DOI: 10.1002/mnfr.202100613
    Complete structured claim and evidence

  2. The tested micellar preparation increased plasma AUC 57-fold relative to native curcumin.

    Micellar curcumin formulation → Human circulating curcumin conjugate exposure source_derived_draftungraded
    Experimental context and source evidence
    evidence_span
    {"source_cache": "artifacts/curcumin-research/34665507.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "19c566913aafc2ec8b5ac2d7053d7a94096ab234f4e5179af18eb1cdeeef5a2c", "start_char": 0, "end_char": 1481, "text_sha256": "19c566913aafc2ec8b5ac2d7053d7a94096ab234f4e5179af18eb1cdeeef5a2c"}
    experimental_model
    Randomized crossover pharmacokinetics plus simulated digestion
    exposure
    207 mg curcumin from eight preparations; 24-hour sampling
    limitations
    Measured circulating material was conjugated, with no free curcumin detected. Formulation exposure is not a clinical efficacy endpoint.
    nutrient_topic
    Curcumin research collection; topical membership is not evidence of a direct dietary effect. · Curcumin
    organism
    Twelve healthy adults; in-vitro digestion separately scoped
    plain_language
    The delivery system changed measured exposure.
    primary_references
    [curcumin-p34665507] Increasing Post-Digestive Solubility of Curcumin Is the Most Successful Strategy to Improve its Oral Bioavailability: A Randomized Cross-Over Trial in Healthy Adults and In Vitro Bioaccessibility Experiments. (2021). https://pubmed.ncbi.nlm.nih.gov/34665507/ DOI: 10.1002/mnfr.202100613
    tissue_or_cell_type
    Plasma and digestive test system

    Curcumin: metabolism, signaling and nutrient connections (2026-09-17) · lines 281–292

    AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Randomized crossover pharmacokinetics plus simulated digestion · source_derived_draft · unverified_draft

    ### curcumin-micellar-exposure The tested micellar preparation increased plasma AUC 57-fold relative to native curcumin. Condition category: normal nutrient_topic: Curcumin research collection; topical membership is not evidence of a direct dietary effect. plain_language: The delivery system changed measured exposure. organism: Twelve healthy adults; in-vitro digestion separately scoped tissue_or_cell_type: Plasma and digestive test system experimental_model: Randomized crossover pharmacokinetics plus simulated digestion limitations: Measured circulating material was conjugated, with no free curcumin detected. Formulation exposure is not a clinical efficacy endpoint. exposure: 207 mg curcumin from eight preparations; 24-hour sampling evidence_span: {"source_cache": "artifacts/curcumin-research/34665507.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "19c566913aafc2ec8b5ac2d7053d7a94096ab234f4e5179af18eb1cdeeef5a2c", "start_char": 0, "end_char": 1481, "text_sha256": "19c566913aafc2ec8b5ac2d7053d7a94096ab234f4e5179af18eb1cdeeef5a2c"} [curcumin-p34665507] Increasing Post-Digestive Solubility of Curcumin Is the Most Successful Strategy to Improve its Oral Bioavailability: A Randomized Cross-Over Trial in Healthy Adults and In Vitro Bioaccessibility Experiments. (2021). https://pubmed.ncbi.nlm.nih.gov/34665507/ DOI: 10.1002/mnfr.202100613
    Complete structured claim and evidence

  3. Glucuronide and sulfate conjugates were detected in all participants.

    Curcumin → Human circulating curcumin conjugate exposure source_derived_draftungraded
    Experimental context and source evidence
    evidence_span
    {"source_cache": "artifacts/curcumin-research/18559556.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "1170d8765efee654882cc57cb7c4cf5f48bb4cb79fe5426a679f5bc27e886ee1", "start_char": 0, "end_char": 1500, "text_sha256": "1170d8765efee654882cc57cb7c4cf5f48bb4cb79fe5426a679f5bc27e886ee1"}
    experimental_model
    Single-dose pharmacokinetics in healthy volunteers
    exposure
    10- or 12-g oral preparation; sampling through 72 hours; free-curcumin detection limit 50 ng/mL
    limitations
    High historical experimental doses; a conjugate measurement must not be relabeled free curcumin.
    nutrient_topic
    Curcumin research collection; topical membership is not evidence of a direct dietary effect. · Curcumin
    organism
    Homo sapiens
    plain_language
    Most measurable circulating material was chemically conjugated.
    primary_references
    [curcumin-p18559556] Pharmacokinetics of curcumin conjugate metabolites in healthy human subjects. (2008). https://pubmed.ncbi.nlm.nih.gov/18559556/ DOI: 10.1158/1055-9965.epi-07-2693
    tissue_or_cell_type
    Plasma

    Curcumin: metabolism, signaling and nutrient connections (2026-09-17) · lines 255–266

    AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Single-dose pharmacokinetics in healthy volunteers · source_derived_draft · unverified_draft

    ### curcumin-pk-conjugates Glucuronide and sulfate conjugates were detected in all participants. Condition category: normal nutrient_topic: Curcumin research collection; topical membership is not evidence of a direct dietary effect. plain_language: Most measurable circulating material was chemically conjugated. organism: Homo sapiens tissue_or_cell_type: Plasma experimental_model: Single-dose pharmacokinetics in healthy volunteers limitations: High historical experimental doses; a conjugate measurement must not be relabeled free curcumin. exposure: 10- or 12-g oral preparation; sampling through 72 hours; free-curcumin detection limit 50 ng/mL evidence_span: {"source_cache": "artifacts/curcumin-research/18559556.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "1170d8765efee654882cc57cb7c4cf5f48bb4cb79fe5426a679f5bc27e886ee1", "start_char": 0, "end_char": 1500, "text_sha256": "1170d8765efee654882cc57cb7c4cf5f48bb4cb79fe5426a679f5bc27e886ee1"} [curcumin-p18559556] Pharmacokinetics of curcumin conjugate metabolites in healthy human subjects. (2008). https://pubmed.ncbi.nlm.nih.gov/18559556/ DOI: 10.1158/1055-9965.epi-07-2693
    Complete structured claim and evidence

In the sources

Preserved passages that mention this component, quoted exactly. Open one to read it in context.

    This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.

    Evidence, AI assistance and curation standards