{"id":"ef9825a4-5e30-5b8f-b1d7-b28329f8bae0","stable_key":"53d9b98d-e3a0-5416-bc88-adbe42a8cb1b:curcumin-pk-conjugates","predicate":"produces","statement":"Glucuronide and sulfate conjugates were detected in all participants.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"226d5454-4097-53a3-ad67-77704267f341","mechanism_event_label":"Most measurable circulating material was chemically conjugated.","subject":{"id":"0e625439-d093-5d1b-8713-dcfdafcf6811","slug":"curcumin","display_name":"Curcumin","entity_type_key":"small_molecule"},"object":{"id":"13b6ee97-7a9c-51c7-9b8e-2a6fc2173b73","slug":"curcumin-conjugate-exposure","display_name":"Human circulating curcumin conjugate exposure","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"226d5454-4097-53a3-ad67-77704267f341","stable_key":"53d9b98d-e3a0-5416-bc88-adbe42a8cb1b:curcumin-pk-conjugates-event","event_type":"observed_intervention","label":"Most measurable circulating material was chemically conjugated.","description":"Glucuronide and sulfate conjugates were detected in all participants.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"ff6d7228-be20-5ac6-9ad5-5d07d41f6644","slug":"curcumin-glucuronide","display_name":"Curcumin glucuronide","entity_type_key":"small_molecule"},"role":"measured_conjugate","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"9478dcfc-a771-5e31-8203-ded1b0fbd447","slug":"curcumin-sulfate","display_name":"Curcumin sulfate","entity_type_key":"small_molecule"},"role":"measured_conjugate","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"0e625439-d093-5d1b-8713-dcfdafcf6811","slug":"curcumin","display_name":"Curcumin","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""},{"entity":{"id":"13b6ee97-7a9c-51c7-9b8e-2a6fc2173b73","slug":"curcumin-conjugate-exposure","display_name":"Human circulating curcumin conjugate exposure","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":3,"notes":""}]},"contexts":[{"dimension":"evidence_span","value_text":"{\"source_cache\": \"artifacts/curcumin-research/18559556.abstract.txt\", \"locator\": \"Primary indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"1170d8765efee654882cc57cb7c4cf5f48bb4cb79fe5426a679f5bc27e886ee1\", \"start_char\": 0, \"end_char\": 1500, \"text_sha256\": \"1170d8765efee654882cc57cb7c4cf5f48bb4cb79fe5426a679f5bc27e886ee1\"}","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Single-dose pharmacokinetics in healthy volunteers","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure","value_text":"10- or 12-g oral preparation; sampling through 72 hours; free-curcumin detection limit 50 ng/mL","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"High historical experimental doses; a conjugate measurement must not be relabeled free curcumin.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Curcumin research collection; topical membership is not evidence of a direct dietary effect.","comparator":null,"unit":null,"notes":"","entity":{"slug":"curcumin","display_name":"Curcumin","entity_type_key":"small_molecule"}},{"dimension":"organism","value_text":"Homo sapiens","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"Most measurable circulating material was chemically conjugated.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[curcumin-p18559556] Pharmacokinetics of curcumin conjugate metabolites in healthy human subjects. (2008). https://pubmed.ncbi.nlm.nih.gov/18559556/ DOI: 10.1158/1055-9965.epi-07-2693","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"Plasma","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"25edad77-4095-50a0-958b-345d26916792","evidence_kind":"source_excerpt","locator":"Lines 255-266","start_line":255,"end_line":266,"excerpt":"### curcumin-pk-conjugates\nGlucuronide and sulfate conjugates were detected in all participants.\nCondition category: normal\nnutrient_topic: Curcumin research collection; topical membership is not evidence of a direct dietary effect.\nplain_language: Most measurable circulating material was chemically conjugated.\norganism: Homo sapiens\ntissue_or_cell_type: Plasma\nexperimental_model: Single-dose pharmacokinetics in healthy volunteers\nlimitations: High historical experimental doses; a conjugate measurement must not be relabeled free curcumin.\nexposure: 10- or 12-g oral preparation; sampling through 72 hours; free-curcumin detection limit 50 ng/mL\nevidence_span: {\"source_cache\": \"artifacts/curcumin-research/18559556.abstract.txt\", \"locator\": \"Primary indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"1170d8765efee654882cc57cb7c4cf5f48bb4cb79fe5426a679f5bc27e886ee1\", \"start_char\": 0, \"end_char\": 1500, \"text_sha256\": \"1170d8765efee654882cc57cb7c4cf5f48bb4cb79fe5426a679f5bc27e886ee1\"}\n[curcumin-p18559556] Pharmacokinetics of curcumin conjugate metabolites in healthy human subjects. (2008). https://pubmed.ncbi.nlm.nih.gov/18559556/ DOI: 10.1158/1055-9965.epi-07-2693","model_system":"Single-dose pharmacokinetics in healthy volunteers","directness":"author_interpretation","verification_status":"source_derived_draft","notes":"Exact curation-document quotation, not publisher quotation. Study references: [curcumin-p18559556] Pharmacokinetics of curcumin conjugate metabolites in healthy human subjects. (2008). https://pubmed.ncbi.nlm.nih.gov/18559556/ DOI: 10.1158/1055-9965.epi-07-2693","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"11d29ea9-3af1-5404-a68d-6f129e23edee","stable_key":"import-53d9b98d-e3a0-5416-bc88-adbe42a8cb1b","title":"Curcumin: metabolism, signaling and nutrient connections (2026-09-17)","document_type":"imported_text","citation_label":"AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text.","file_path":"","sha256":"6eeda0e6e358e0b19f73f554f8c027cb08015aa49d92a77bde36e3fb3ea1a41c","revision_id":"32e73d69-5445-5ace-b25d-5a4d3787aea5","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}