Component
Gamma-cyclodextrin curcumin formulation
Gamma-cyclodextrin curcumin formulation. Species, exposure and limitations are retained in each linked claim.
1 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
What it acts on
The gamma-cyclodextrin preparation increased plasma AUC 30-fold relative to native curcumin.
Experimental context and source evidence
- evidence_span
- {"source_cache": "artifacts/curcumin-research/34665507.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "19c566913aafc2ec8b5ac2d7053d7a94096ab234f4e5179af18eb1cdeeef5a2c", "start_char": 0, "end_char": 1481, "text_sha256": "19c566913aafc2ec8b5ac2d7053d7a94096ab234f4e5179af18eb1cdeeef5a2c"}
- experimental_model
- Randomized crossover pharmacokinetics plus simulated digestion
- exposure
- 207 mg curcumin from eight preparations; 24-hour sampling
- limitations
- Measured circulating material was conjugated, with no free curcumin detected. Formulation exposure is not a clinical efficacy endpoint.
- nutrient_topic
- Curcumin research collection; topical membership is not evidence of a direct dietary effect. · Curcumin
- organism
- Twelve healthy adults; in-vitro digestion separately scoped
- plain_language
- A different delivery system also changed exposure.
- primary_references
- [curcumin-p34665507] Increasing Post-Digestive Solubility of Curcumin Is the Most Successful Strategy to Improve its Oral Bioavailability: A Randomized Cross-Over Trial in Healthy Adults and In Vitro Bioaccessibility Experiments. (2021). https://pubmed.ncbi.nlm.nih.gov/34665507/ DOI: 10.1002/mnfr.202100613
- tissue_or_cell_type
- Plasma and digestive test system
Curcumin: metabolism, signaling and nutrient connections (2026-09-17) · lines 294–305
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Randomized crossover pharmacokinetics plus simulated digestion · source_derived_draft · unverified_draft
### curcumin-cyclodextrin-exposure The gamma-cyclodextrin preparation increased plasma AUC 30-fold relative to native curcumin. Condition category: normal nutrient_topic: Curcumin research collection; topical membership is not evidence of a direct dietary effect. plain_language: A different delivery system also changed exposure. organism: Twelve healthy adults; in-vitro digestion separately scoped tissue_or_cell_type: Plasma and digestive test system experimental_model: Randomized crossover pharmacokinetics plus simulated digestion limitations: Measured circulating material was conjugated, with no free curcumin detected. Formulation exposure is not a clinical efficacy endpoint. exposure: 207 mg curcumin from eight preparations; 24-hour sampling evidence_span: {"source_cache": "artifacts/curcumin-research/34665507.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "19c566913aafc2ec8b5ac2d7053d7a94096ab234f4e5179af18eb1cdeeef5a2c", "start_char": 0, "end_char": 1481, "text_sha256": "19c566913aafc2ec8b5ac2d7053d7a94096ab234f4e5179af18eb1cdeeef5a2c"} [curcumin-p34665507] Increasing Post-Digestive Solubility of Curcumin Is the Most Successful Strategy to Improve its Oral Bioavailability: A Randomized Cross-Over Trial in Healthy Adults and In Vitro Bioaccessibility Experiments. (2021). https://pubmed.ncbi.nlm.nih.gov/34665507/ DOI: 10.1002/mnfr.202100613
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.