Component
Cognitive performance in creatine intervention studies
Cognitive performance in creatine intervention studies. Species, exposure and limitations are retained in each linked claim.
2 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
What acts on it
Neither primary cognitive test reached conventional statistical significance; exploratory tasks showed no indication of improvement, and vegetarians did not benefit more than omnivores.
Experimental context and source evidence
- evidence_span
- {"source_cache": "artifacts/creatine-research/37968687.abstract.txt", "locator": "Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "bf6121a3717d28c7cca0ae08a4ff612dc0f0d5fcfa610cbfb03c942a7a831798", "start_char": 0, "end_char": 1953, "text_sha256": "bf6121a3717d28c7cca0ae08a4ff612dc0f0d5fcfa610cbfb03c942a7a831798"}
- experimental_model
- Preregistered randomized double-blind crossover trial
- exposure
- 5 g/day creatine for six weeks versus placebo
- limitations
- Backward digit span P=0.064 and Raven matrices P=0.327; Bayesian interpretation suggested a possible small effect. No established broad cognitive benefit or vegetarian-specific advantage.
- nutrient_topic
- Creatine research collection; topical membership is not evidence of a direct dietary effect. · Creatine
- organism
- 123 vegetarian and omnivorous participants
- plain_language
- The larger trial left a possible small benefit uncertain and did not demonstrate a broad cognitive boost.
- primary_references
- [creatine-p37968687] The effects of creatine supplementation on cognitive performance-a randomised controlled study. (2023). https://pubmed.ncbi.nlm.nih.gov/37968687/ DOI: 10.1186/s12916-023-03146-5
- tissue_or_cell_type
- Cognitive testing
Creatine: synthesis, transport, phosphocreatine energetics and nutrient interactions (2026-09-17) · lines 1036–1047
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Preregistered randomized double-blind crossover trial · source_derived_draft · unverified_draft
### creatine-cognition-context Neither primary cognitive test reached conventional statistical significance; exploratory tasks showed no indication of improvement, and vegetarians did not benefit more than omnivores. Condition category: normal nutrient_topic: Creatine research collection; topical membership is not evidence of a direct dietary effect. plain_language: The larger trial left a possible small benefit uncertain and did not demonstrate a broad cognitive boost. organism: 123 vegetarian and omnivorous participants tissue_or_cell_type: Cognitive testing experimental_model: Preregistered randomized double-blind crossover trial limitations: Backward digit span P=0.064 and Raven matrices P=0.327; Bayesian interpretation suggested a possible small effect. No established broad cognitive benefit or vegetarian-specific advantage. exposure: 5 g/day creatine for six weeks versus placebo evidence_span: {"source_cache": "artifacts/creatine-research/37968687.abstract.txt", "locator": "Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "bf6121a3717d28c7cca0ae08a4ff612dc0f0d5fcfa610cbfb03c942a7a831798", "start_char": 0, "end_char": 1953, "text_sha256": "bf6121a3717d28c7cca0ae08a4ff612dc0f0d5fcfa610cbfb03c942a7a831798"} [creatine-p37968687] The effects of creatine supplementation on cognitive performance-a randomised controlled study. (2023). https://pubmed.ncbi.nlm.nih.gov/37968687/ DOI: 10.1186/s12916-023-03146-5
Complete structured claim and evidenceThe study reported improved cognitive performance and processing speed after the single high dose during sleep deprivation.
Experimental context and source evidence
- evidence_span
- {"source_cache": "artifacts/creatine-research/38418482.abstract.txt", "locator": "Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "b6dad9388eb7cb8986f1873e6ba9f8dd36924c7a9aa7c661059cde1012f1e3a8", "start_char": 0, "end_char": 1364, "text_sha256": "b6dad9388eb7cb8986f1873e6ba9f8dd36924c7a9aa7c661059cde1012f1e3a8"}
- experimental_model
- Placebo comparison with repeated phosphorus/proton MRS and cognition
- exposure
- Single creatine monohydrate dose 0.35 g/kg during approximately 21 hours of sleep deprivation
- limitations
- Acute high-dose, sleep-deprivation setting; not an everyday dose recommendation or proof of benefit in well-rested people.
- nutrient_topic
- Creatine research collection; topical membership is not evidence of a direct dietary effect. · Creatine
- organism
- Human participants during sleep deprivation
- plain_language
- The positive result applies to this demanding sleep-loss setting.
- primary_references
- [creatine-p38418482] Single dose creatine improves cognitive performance and induces changes in cerebral high energy phosphates during sleep deprivation. (2024). https://pubmed.ncbi.nlm.nih.gov/38418482/ DOI: 10.1038/s41598-024-54249-9
- tissue_or_cell_type
- Brain spectroscopy and cognitive performance
Creatine: synthesis, transport, phosphocreatine energetics and nutrient interactions (2026-09-17) · lines 1062–1073
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Placebo comparison with repeated phosphorus/proton MRS and cognition · source_derived_draft · unverified_draft
### creatine-sleep-deprivation-cognition The study reported improved cognitive performance and processing speed after the single high dose during sleep deprivation. Condition category: normal nutrient_topic: Creatine research collection; topical membership is not evidence of a direct dietary effect. plain_language: The positive result applies to this demanding sleep-loss setting. organism: Human participants during sleep deprivation tissue_or_cell_type: Brain spectroscopy and cognitive performance experimental_model: Placebo comparison with repeated phosphorus/proton MRS and cognition limitations: Acute high-dose, sleep-deprivation setting; not an everyday dose recommendation or proof of benefit in well-rested people. exposure: Single creatine monohydrate dose 0.35 g/kg during approximately 21 hours of sleep deprivation evidence_span: {"source_cache": "artifacts/creatine-research/38418482.abstract.txt", "locator": "Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "b6dad9388eb7cb8986f1873e6ba9f8dd36924c7a9aa7c661059cde1012f1e3a8", "start_char": 0, "end_char": 1364, "text_sha256": "b6dad9388eb7cb8986f1873e6ba9f8dd36924c7a9aa7c661059cde1012f1e3a8"} [creatine-p38418482] Single dose creatine improves cognitive performance and induces changes in cerebral high energy phosphates during sleep deprivation. (2024). https://pubmed.ncbi.nlm.nih.gov/38418482/ DOI: 10.1038/s41598-024-54249-9
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.