{"id":"0fdbae8f-5f82-57c1-bf8f-b2241b05a01b","stable_key":"44737fa3-b335-53f4-a644-b9878d4416ac:creatine-sleep-deprivation-cognition","predicate":"improved_under_sleep_deprivation","statement":"The study reported improved cognitive performance and processing speed after the single high dose during sleep deprivation.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"a999ef1f-e47d-5a58-a7e1-2affab25ce63","mechanism_event_label":"The positive result applies to this demanding sleep-loss setting.","subject":{"id":"399b373f-0034-5f2b-83b7-637eb2678c83","slug":"creatine-monohydrate","display_name":"Creatine monohydrate","entity_type_key":"small_molecule"},"object":{"id":"02918e94-ca19-5a05-8767-41cc6e3b3f1b","slug":"creatine-cognitive-performance","display_name":"Cognitive performance in creatine intervention studies","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"a999ef1f-e47d-5a58-a7e1-2affab25ce63","stable_key":"44737fa3-b335-53f4-a644-b9878d4416ac:creatine-sleep-deprivation-cognition-event","event_type":"observed_intervention","label":"The positive result applies to this demanding sleep-loss setting.","description":"The study reported improved cognitive performance and processing speed after the single high dose during sleep deprivation.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"399b373f-0034-5f2b-83b7-637eb2678c83","slug":"creatine-monohydrate","display_name":"Creatine monohydrate","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"02918e94-ca19-5a05-8767-41cc6e3b3f1b","slug":"creatine-cognitive-performance","display_name":"Cognitive performance in creatine intervention studies","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""}]},"contexts":[{"dimension":"evidence_span","value_text":"{\"source_cache\": \"artifacts/creatine-research/38418482.abstract.txt\", \"locator\": \"Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"b6dad9388eb7cb8986f1873e6ba9f8dd36924c7a9aa7c661059cde1012f1e3a8\", \"start_char\": 0, \"end_char\": 1364, \"text_sha256\": \"b6dad9388eb7cb8986f1873e6ba9f8dd36924c7a9aa7c661059cde1012f1e3a8\"}","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Placebo comparison with repeated phosphorus/proton MRS and cognition","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure","value_text":"Single creatine monohydrate dose 0.35 g/kg during approximately 21 hours of sleep deprivation","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Acute high-dose, sleep-deprivation setting; not an everyday dose recommendation or proof of benefit in well-rested people.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Creatine research collection; topical membership is not evidence of a direct dietary effect.","comparator":null,"unit":null,"notes":"","entity":{"slug":"creatine","display_name":"Creatine","entity_type_key":"small_molecule"}},{"dimension":"organism","value_text":"Human participants during sleep deprivation","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"The positive result applies to this demanding sleep-loss setting.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[creatine-p38418482] Single dose creatine improves cognitive performance and induces changes in cerebral high energy phosphates during sleep deprivation. (2024). https://pubmed.ncbi.nlm.nih.gov/38418482/ DOI: 10.1038/s41598-024-54249-9","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"Brain spectroscopy and cognitive performance","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"2ba7aecc-b902-53e8-8972-e6381eaccbcd","evidence_kind":"source_excerpt","locator":"Lines 1062-1073","start_line":1062,"end_line":1073,"excerpt":"### creatine-sleep-deprivation-cognition\nThe study reported improved cognitive performance and processing speed after the single high dose during sleep deprivation.\nCondition category: normal\nnutrient_topic: Creatine research collection; topical membership is not evidence of a direct dietary effect.\nplain_language: The positive result applies to this demanding sleep-loss setting.\norganism: Human participants during sleep deprivation\ntissue_or_cell_type: Brain spectroscopy and cognitive performance\nexperimental_model: Placebo comparison with repeated phosphorus/proton MRS and cognition\nlimitations: Acute high-dose, sleep-deprivation setting; not an everyday dose recommendation or proof of benefit in well-rested people.\nexposure: Single creatine monohydrate dose 0.35 g/kg during approximately 21 hours of sleep deprivation\nevidence_span: {\"source_cache\": \"artifacts/creatine-research/38418482.abstract.txt\", \"locator\": \"Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"b6dad9388eb7cb8986f1873e6ba9f8dd36924c7a9aa7c661059cde1012f1e3a8\", \"start_char\": 0, \"end_char\": 1364, \"text_sha256\": \"b6dad9388eb7cb8986f1873e6ba9f8dd36924c7a9aa7c661059cde1012f1e3a8\"}\n[creatine-p38418482] Single dose creatine improves cognitive performance and induces changes in cerebral high energy phosphates during sleep deprivation. (2024). https://pubmed.ncbi.nlm.nih.gov/38418482/ DOI: 10.1038/s41598-024-54249-9","model_system":"Placebo comparison with repeated phosphorus/proton MRS and cognition","directness":"author_interpretation","verification_status":"source_derived_draft","notes":"Exact curation-document quotation, not publisher quotation. Study references: [creatine-p38418482] Single dose creatine improves cognitive performance and induces changes in cerebral high energy phosphates during sleep deprivation. (2024). https://pubmed.ncbi.nlm.nih.gov/38418482/ DOI: 10.1038/s41598-024-54249-9","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"70358046-c5c3-5e9a-9fc9-eb01c3fff88b","stable_key":"import-44737fa3-b335-53f4-a644-b9878d4416ac","title":"Creatine: synthesis, transport, phosphocreatine energetics and nutrient interactions (2026-09-17)","document_type":"imported_text","citation_label":"AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text.","file_path":"","sha256":"548237d3e98a73a7dc02181807921fdd8b902adcee46248792258a761593eda9","revision_id":"88738255-8028-52fb-9c12-0fe92d8ce367","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}